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Probiotic milk may keep triathletes Sniffle-Free

NCT ID NCT06970964

Disease control Sponsor: Federal University of São Paulo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a daily probiotic drink (like Yakult) can reduce cold symptoms in triathletes before and after a competition. 80 healthy amateur triathletes drank either the probiotic or a placebo for 30 days before and 14 days after a race. Researchers tracked symptoms and immune markers to see if the probiotic helped.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
fermented milk containing Lacticaseibacillus paracasei strain Shirota (probiotic)
What this could lead to
If it works, this could offer a simple, non-drug way for athletes to reduce cold symptoms during intense training and competition.
What could go wrong
This is a small, early-stage study in healthy athletes, so results may not apply to the general public. The effect may be small or no different from placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

80 people

The number who actually took part.

Started

Aug 2025

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged between 25 and 45 years. * Amateur triathletes with regular endurance training and prior competition experience. * In good general health, with no history of chronic diseases or conditions affecting immune or inflammatory responses. * Willing and able to comply with all study procedures, including sample collections and completion of validated questionnaires at five time points. * Agree to consume a daily dose of fermented milk containing Lacticaseibacillus paracasei strain Shirota (LcS) or placebo from 30 days before until 14 days after the competition. * No use of probiotics, antibiotics, or immunomodulatory supplements in the 30 days prior to enrollment Exclusion Criteria: * Known allergy or intolerance to dairy products, including lactose. * Use of probiotics or antibiotics within 30 days prior to enrollment. * Current use of any pharmacological treatment. * History of chronic rhinopathy. * Diagnosis of autoimmune disease. * History of recurrent infections not involving the upper airway. * Presence of major medical conditions or chronic diseases, including but not limited to respiratory or gastrointestinal disorders. * Incomplete or missing data necessary for determining eligibility or for study outcomes.

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Conditions

The condition(s) this trial relates to.

depressive disorder Inflammation Motor Activity Psychological Well-Being respiratory tract infectious disorder Signs and Symptoms, Respiratory

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Athletic performance Cytokine response Depressive disorder Exercise-induced immunosuppression Mental health Mucosal immunity Probiotic therapy Respiratory tract infections (RTI) Systemic inflammation Upper respiratory tract symptoms

Contacts and locations

Locations

  • Federal University of Sao Paulo

    São Paulo, São Paulo, 04039-032, Brazil

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