New checklist could make surgery safer for kids with colds
NCT ID NCT04155892
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at 760 children under 8 years old who had surgery with a breathing tube. Some had cold symptoms, others did not. Researchers tested five simple signs—like facial grimace and eye opening—to see if they could predict a safe breathing tube removal. The goal was to find a better way to decide when it's safe to take the tube out, reducing breathing problems after surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to a simple checklist to help doctors decide when it's safe to remove a breathing tube in children with colds, reducing complications.
- What could go wrong
- This is an observational study, not a treatment trial. It only gathers data and does not test a new drug or therapy. Results may not apply to all hospitals or children.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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760 people
The number who actually took part.
- Started
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Dec 2019
- Finished
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Jul 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
* All study participants must be \< 8 years of age and undergoing general anesthesia and surgery with an endotracheal tube * The URI group will be participants with a score of at least 3 on our pre-operative URI survey, with planned airway instrumentation with an ETT for their surgical procedure who are to be discharged same day or on postoperative day 1. * The non URI group will be participants undergoing elective procedures with no URI symptom or recent URI. Defined as no URI or "allergy" symptom within the past 6 weeks and a score of 1 or less on the URI survey, with planned airway instrumentation with an ETT for their surgical procedure who are to be discharged same day or on postoperative day 1.
- Ages
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Up to 7 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * All study participants must be undergoing general anesthesia and surgery with an endotracheal tube * The URI group will be participants with a score of at least 3 on our pre-operative URI survey, with planned airway instrumentation with an endotracheal tube (ETT) for their surgical procedure who are to be discharged same day or on postoperative day 1. * The non URI group will be participants undergoing elective procedures with no URI symptom or recent URI. Defined as no URI or "allergy" symptom within the past 6 weeks and a score of 1 or less on the URI survey, with planned airway instrumentation with an ETT for their surgical procedure who are to be discharged same day or on postoperative day 1. Exclusion Criteria: * History of home oxygen use or ventilator dependence, * Patients undergoing emergent procedures. * Patients with cyanotic congenital heart disease. * Patients receiving a surgical procedure where the duration of post procedure * admission is anticipated to be greater or equal to 2 postoperative days. * Patients undergoing anesthesia for imaging procedures alone. * Patients who are extubated deep intentionally. * Patients intended to be managed with supraglottic airway. * Patients undergoing total IV anaesthesia (TIVA).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157, United States
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Other studies related to the condition(s) this trial covers.