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New EHR tool helps nurses cut unnecessary antibiotic prescriptions

NCT ID NCT04255303

Knowledge-focused Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a computer tool that helps nurses decide when antibiotics are needed for common respiratory infections like colds and sore throats. The tool, built into the electronic health record, calculates a patient's risk and suggests appropriate care. Researchers measured whether the tool changed prescribing habits and how useful nurses found it.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Integrated clinical prediction rule (iCPR) system
What this could lead to
If successful, this tool could help nurses prescribe antibiotics more appropriately, reducing unnecessary use and fighting antibiotic resistance.
What could go wrong
This is a completed implementation study, not a treatment trial. The tool's impact on actual patient outcomes or long-term prescribing habits may be limited.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

347 people

The number who actually took part.

Started

Feb 2022

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Clinics: * must be primary care and/or urgent care clinics * should have a minimum of one registered nurse (RN) full time equivalents (FTE) Nurses : * be licensed to see patients and prescribed and/or recommend prescriptions for patients * work a minimum of 0.5 FTE to ensure that they are seeing sufficient numbers of patients to maintain competency * have access to the clinic EHR system, and use regularly as part of patient care Patients: * patients must have been seen at a participating clinic with a complaint of cough or sore throat. * Ages 3-70 will be included for sore throat and ages 18-70 for cough Exclusion Criteria: * are unable or unwilling to provide informed consent * are unable to participate meaningfully in an intervention that involves self-monitoring using software available in English (e.g., due to uncorrected sight impairment, illiterate, non-English-speaking, dementia) * clinics will be excluded if phone call triage of patients with sore throat and cough is not performed by RNs * Nurses will be excluded if they do not work with the clinic EHR as part of their workflow * Patients with a history of chronic lung disease or immunosuppression will be excluded since the CPRs were not validated in these groups

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Conditions

The condition(s) this trial relates to.

respiratory tract infectious disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory infection

Contacts and locations

Locations

  • NYU Langone Health

    New York, New York, 10016, United States

  • University of Utah School of Medicine

    Salt Lake City, Utah, 84112, United States

  • University of Wisconsin

    Madison, Wisconsin, 53705, United States

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