Probiotic pill may ward off winter colds, study finds
NCT ID NCT06827327
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a daily probiotic called LC-Plasma can prevent upper respiratory tract infections (like colds) in healthy adults aged 18-60 who often get sick. Over 600 participants took either the probiotic or a placebo pill every day for 24 weeks. Researchers tracked how many people got sick and how severe their symptoms were.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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637 people
The number who actually took part.
- Started
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Mar 2025
- Finished
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Jan 2026
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged 18-60 years living in Australia * Individuals with a history of recurrent upper respiratory tract infections * Able to provide informed consent * Generally healthy * Agree to not participate in another clinical trial while enrolled in this trial * Agree to maintain their usual daily activities without significant changes. This includes not changing their current diet or stopping/starting a new exercise regimen during entire study period * Agree not to travel internationally for over 1 month in a single trip during the intervention period (baseline to study completion). * Females of childbearing potential must a prescribed form of birth control Exclusion Criteria: * Serious illness e.g., liver disease, kidney disease, heart disease, mood disorders, neurological disorders such as multiple sclerosis. * Unstable illness e.g., changing medication/treatment. * BMI \<18.5, \>30 * Current malignancy (excluding Basal Cell Carcinoma) or chemotherapy or radiotherapy treatment for malignancy within the previous 2 years. * Individuals with chronic respiratory conditions (e.g., asthma, chronic obstructive pulmonary disease). * Has current symptoms of an acute sickness. * Active smokers, nicotine use or drug (prescription or illegal substances) abuse * Current alcohol use (\>14 alcoholic drinks week) * Allergic to any of the ingredients in the active or placebo formula * Pregnant or lactating woman * People medically prescribed medications within the last month that would affect the immune and/or the inflammatory response excluding topical steroid use. * Participants who are currently participating in any other clinical trial or who have participated in any other clinical trial during the past 1 month * Participants with cognitive damage * Participants with seasonal allergic rhinitis * Regular use of antihistamines * Individuals deemed unsuitable for participation by the Principal Investigator (PI) of this study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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RDC Clinical
Brisbane, Queensland, 4006, Australia
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Other studies related to the condition(s) this trial covers.
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