Personality disorder

This study tested a noninvasive brain stimulation technique (transcranial random noise stimulation) to see if it could reduce cravings in 225 adults with substance use disorder plus another psychiatric condition like ADHD, bipolar disorder, or schizophrenia. The approach targeted…

This trial tests whether a specialized two-year early intervention service, called OPUS YOUNG, can improve daily and social functioning in adolescents aged 12-17 who have experienced a first episode of psychosis. Participants are randomly assigned to either OPUS YOUNG or standard…

This early-stage study is testing whether combining standard psychiatric medications (like antidepressants and anti-anxiety drugs) with individual cognitive behavioral therapy can improve symptoms and daily functioning in people with anxiety, depression, PTSD, OCD, bipolar disord…

This study tests whether a noninvasive brain stimulation technique called iTBS-TMS can reduce suicide risk in adults with major depression or borderline personality disorder who are experiencing suicidal thoughts. Participants receive either real or sham (placebo) stimulation to …

This trial tests a therapy called Multisystemic Therapy for Emerging Adults (MST-EA) for young people aged 16–26 who have a mental illness and a recent arrest or jail release. The therapy is home-based and involves therapists and coaches working with the young adult and their fam…

This study tests whether allowing people with borderline personality disorder and a history of self-harm to admit themselves for up to three nights (three times per month) reduces the use of compulsory (forced) psychiatric care. Researchers will compare clinics that implement thi…

This study looked at 6 people with schizophrenia who were already taking a combination of two long-acting injectable medications: Abilify Maintena and Rexulti. Researchers tracked their symptoms and side effects over 6 months to see how well the combo worked in everyday life. The…

This study tested a therapy called Multisystemic Therapy-Emerging Adults (MST-EA) for young people aged 16-26 with substance use issues and recent arrests. The therapy works with the young adult and their social network at home and in the community to reduce criminal behavior and…

This study tested a step-by-step treatment approach for 342 young people aged 12-25 who are at ultra high risk of developing psychosis. The goal was to see if a sequence of therapies and medications could improve daily functioning and reduce the chance of psychosis. The approach …

This study looked at whether schema therapy, a type of talk therapy, can help people with personality disorders who are in outpatient forensic care. Five participants received therapy for up to two years. Researchers measured changes in their thinking patterns, risk of re-offendi…

This study tested whether a computerized training program that targets emotional reactions can help relieve obsessive thoughts and compulsive behaviors in people with OCD. Five adults with OCD completed 14 training sessions over three weeks. The goal was to see if this approach c…

This trial tests whether adding virtual reality to cognitive behavioural therapy (CBT) can better reduce persecutory thoughts in people with schizophrenia spectrum disorders compared to traditional CBT alone. About 256 participants will receive either VR-assisted CBT or standard …

This study tests whether an 8-week mindful self-compassion program can reduce self-harm, improve emotional control, and boost quality of life in 60 adults with borderline personality disorder. Participants learn mindfulness and self-kindness techniques. The goal is to see if this…

This early-stage study tests whether a new medicine called BI 3031185 is safe and well-tolerated in adults with borderline personality disorder (BPD) or attention-deficit/hyperactivity disorder (ADHD). About 96 participants will receive either the drug or a placebo in a crossover…

This study explores whether a single-session sleep training program can improve sleep and reduce symptoms of borderline personality disorder (BPD) in teenagers. Teens aged 13-18 with BPD symptoms will receive a brief intervention based on the TSC-Youth protocol, which teaches hea…

This trial tests a new couple-based therapy called Sage for people with borderline personality disorder who struggle with self-injury or suicidal thoughts. The therapy, delivered remotely over 12 sessions, aims to reduce these behaviors by addressing both emotional distress and r…

This study tested whether Caplyta (lumateperone), a drug already used for other mental health conditions, can reduce symptoms of borderline personality disorder (BPD). Sixty adults with BPD received either Caplyta or a placebo pill for 8 weeks. Researchers measured changes in BPD…

This study tests a personalized cognitive training program called CBM-TAF for adults with obsessive-compulsive (OC) symptoms. The program targets a specific thinking pattern known as thought-action fusion (TAF), where people believe having an unwanted thought is as bad as acting …

This study tests a short-term therapy for adults with borderline personality disorder. After a 2-4 week observation period, 30 participants receive six weekly therapy sessions. Researchers measure symptom changes using clinician and self-report scales, then follow participants fo…

This early-phase trial tests a new brain stimulation target for people with depression plus at least one other psychiatric disorder, such as anxiety, OCD, or PTSD. The treatment uses a non-invasive form of brain stimulation called accelerated intermittent theta burst stimulation …

This study tested a program called Family Connections for caregivers of people with both an eating disorder and a personality disorder. The goal was to see if the program could reduce stress and conflict at home. 124 Spanish caregivers took part, and researchers measured things l…

This study tested a new combination of two talk therapies for adults with eating disorders who are not underweight. Twenty participants were randomly assigned to either standard cognitive behavioral therapy (CBT-E) or a mix of CBT and metacognitive interpersonal therapy (CBT-F+MI…

This study tested an experimental drug called vafidemstat in 211 adults with borderline personality disorder (BPD) to see if it could reduce agitation and aggression. Participants took either the drug or a placebo for 14 weeks. The goal was to measure changes in symptom severity …

This study tested whether real-time brain feedback (rtfMRI) could help people with borderline personality disorder increase brain activity in the amygdala while recalling happy memories. Thirty adults with the condition completed the training over several weeks. The goal was to s…

This study compares a 6-month version of dialectical behaviour therapy (DBT) to the standard 1-year program for people with borderline personality disorder who repeatedly self-harm. Researchers want to see if the shorter therapy is just as good at reducing self-harm and is more c…

This study tested whether a smartphone app called SAM could help adults with borderline personality disorder traits manage daily stress. Sixteen participants used the app for four weeks, answering quick stress questions several times a day and getting feedback on their patterns. …

This study tested if group therapy using dialectical behavioral therapy (DBT) works better than one-on-one supportive therapy for people with borderline personality disorder. 66 adults took part, and researchers looked at depression, impulsivity, suicide risk, and other factors. …

This study tested whether watching short online videos about borderline personality disorder (BPD) could help people recently diagnosed with the condition. 83 adults with BPD watched either BPD-specific videos or general mental health videos over two weeks and completed daily sur…

This small Phase 2 trial tested a single 25mg dose of psilocybin in 9 adults with both major depressive disorder and borderline personality disorder. Researchers measured changes in depression and BPD symptoms over time. The goal was to see if psilocybin is safe and could help ea…

This study tested two mobile health (mHealth) strategies to help people with schizophrenia manage their symptoms. 299 participants used smartphone tools to track and improve issues like depression, anxiety, and insomnia. The goal was to see if these digital tools could make a rea…

This study tested whether a 4-week virtual reality (VR) training program could improve thinking skills in 62 people with depression, bipolar disorder, or psychotic disorders like schizophrenia. Participants practiced daily-life tasks in VR, such as cooking and shopping, guided by…

This pilot study uses functional MRI to examine brain activity in trauma-exposed veterans with obsessive-compulsive personality traits, known as overcontrol. Overcontrol can strain relationships and increase suicide risk. The study aims to test whether the brain scanning methods …

This study looked at whether a 12-hour online training course in psychological first aid (based on the RAPID model) could improve people's communication and listening skills. Ten participants completed the training and were tested before and after. The goal was to see if such tra…

This study looked at how different ways of communicating (like talking in person vs. texting) change brain activity. Researchers used fMRI scans on 30 healthy young adults while they watched videos of different communication styles. The goal was to see if each style uses a differ…

This study looked back at the records of 652 patients who were seen in the emergency department of a French hospital and then referred to a special addiction liaison team. The goal was to understand the social and medical backgrounds of these patients. The findings could help hos…

This pilot study tested a community-based intervention for people with psychosis in Malawi, Nigeria, Sierra Leone, and Zimbabwe. The program includes peer support from someone who has experienced psychosis, case management, and help with daily activities like finding work or soci…

This study looked at whether a therapy called FAST (Forensic Outpatient Systemic Therapy) helps teens aged 12-21 with conduct disorder or aggressive behavior. The therapy involves weekly sessions with the teen and their caregivers for several months. Researchers measured changes …

This study looked at how thinking skills and brain activity differ in people who self-harm compared to those who don't. Researchers interviewed 316 adults and gave them thinking tests, with some also having brain scans. The goal was to better understand self-harm to help create m…

This study looked at how empathy works in people with borderline personality disorder (BPD). Researchers used a computer test and questionnaires to measure two types of empathy: understanding others' thoughts and feeling their emotions. About 30 participants were assessed four ti…

This study looked at how the brain's 'mirror system' for touch works in people with borderline personality disorder (BPD). Researchers used a non-invasive brain stimulation technique called TMS to temporarily change brain activity while participants watched a hand being touched. …

This small study looked at whether Mentalization-Based Therapy (MBT) helps people aged 60 and older who struggle in relationships. Researchers recruited 3 participants and used interviews and questionnaires to see if the therapy improved their ability to understand their own and …

This study tested whether combining mental health treatment with job coaching helps people on sick leave due to anxiety, depression, stress, personality disorders, or functional disorders return to work. 900 participants in Denmark received either the combined service or usual ca…

This study looked at how attention and daydreaming influence obsessive thoughts in people with Obsessive Compulsive Disorder (OCD). Researchers compared 80 participants—some with OCD and some without—to see if obsessions change depending on how much the mind wanders. The goal was…

This study looked at how people with obsessive-compulsive disorder (OCD) balance between using habits and goal-directed thinking when making decisions. Researchers used brain scans and mild electrical stimulation to understand the brain circuits involved. The goal was to learn mo…

This study looked at whether a woman's natural temperament (like being more anxious or upbeat) is linked to how severe her menopause symptoms are. Researchers surveyed 105 women going through menopause using two standard questionnaires. The goal was simply to understand connectio…