Veterans' brain scans could unlock new suicide prevention strategies

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: General Inclusion: * All prospective participants must be able to comprehend the study's procedures and associated risks and be capable of providing informed consent. * Mean scores on at least three subscales of the Pathological Obsessive Compulsive Personality Scale (POPS) must be greater than an average score of four (4 = "slightly agree") across subscale items. * The POPS is a 49-item self-report assessment of maladaptive behaviors and thought patterns associated with OCPD. * While Veterans with primary psychotic disorders will be excluded, the presence of other disorders related to obsessive-compulsive tendencies or personality will not be grounds for exclusion. * Psychiatric medication usage will be assessed during enrollment, but this will not serve as an inclusion or exclusion criterion (with an additional stipulation outlined below for the MRI subsample). Exclusion Criteria: General Exclusion: * The Mini International Neuropsychiatric Interview (M.I.N.I.) will be used to exclude participants with current psychosis or with past psychosis that was unrelated to depression. Additional MRI Criteria: * Participants interested in taking part in the MRI portion of the study will undergo a thorough screening to ensure MRI compatibility (e.g., absence of metal in the body, absence of claustrophobia). * Interested participants must meet the following additional criteria: * no medical contraindications for MRI (e.g., pacemakers, non-MRI safe implanted devices) * absence of neurological disorders * no moderate-to-severe traumatic brain injury (e.g., head trauma with loss of consciousness \>5 minutes) * no ongoing poorly controlled substance use disorder. * Lifetime history of seizures, primary or secondary CNS tumors, stroke, or cerebral aneurysm will also be exclusionary. * For participants in the MRI segment of the study, continued medication use will not be a disqualifying factor if the medication regimen has remained stable for the past month, with no intentions of altering dosages during the study duration. * This medication criterion will not be applied to participants who do not complete MRI scans. * For this feasibility trial, individuals exhibiting active suicidal behavior or a score \>3 on the suicidal ideation module of the Columbia-Suicide Severity Rating Scale will be ineligible.