Lymphedema

This study is testing the Symani Surgical System, a robotic device designed to help surgeons perform very delicate microsurgeries. The trial will include 455 adults undergoing free tissue transfer or lymphedema surgery. Researchers will check how well the robot works for reconnec…

This phase 2 trial tests whether pravastatin (a cholesterol drug) or a combination of pentoxifylline and vitamin E can prevent lymphedema and fibrosis (swelling and scarring) caused by radiation therapy in head and neck cancer patients. About 295 adults with oropharyngeal cancer …

This early study tests whether a robot can safely perform microsurgery on deep neck lymph nodes in 15 people with mild-to-moderate Alzheimer's. The idea is that clearing blockages in these lymph nodes might help the brain remove harmful waste. The main goal is to check safety, no…

This phase 2 trial is testing whether a less extensive lymph node surgery, called targeted axillary dissection (TAD), can safely control cancer in women aged 45 and older with early-stage ER+ breast cancer that has spread to lymph nodes detected by ultrasound. Participants will h…

This trial tests whether starting upper limb rehabilitation exercises one day before breast cancer surgery can reduce the risk and severity of arm lymphedema (swelling) after surgery. Half of the participants will receive individualized exercise instruction, while the other half …

This phase 2 trial tests several medications—including pravastatin, pentoxifylline, and others—to see if they can treat or prevent lymphedema and fibrosis caused by radiation therapy in head and neck cancer survivors. About 250 participants who have finished radiation at least 6 …

This study compares two ways of treating chronic leg swelling (lymphedema) using compression bandages. One group receives the standard treatment with a single bandage application each day, while the other group applies the bandage three times daily. The goal is to see if the more…

This study will test the Symani Surgical System, a robotic device designed to help surgeons perform delicate microsurgery on lymph vessels in the head and neck. The goal is to see if the robot can safely and effectively reconnect lymph channels to reduce swelling (lymphedema) in …

This pilot study tests whether a surgical procedure called lymphovenous bypass (LVB) can prevent lymphedema (chronic swelling) when done at the same time as lymph node removal in melanoma patients. About 20 adults with melanoma who need axillary or inguinal lymph node dissection …

This study compares two microsurgical techniques (LVA and VLNT) against standard conservative therapy for chronic arm swelling after breast cancer treatment. Researchers will measure quality of life in 280 participants one year after surgery. The goal is to see if surgery provide…

This study is testing a robotic system called Symani to help surgeons perform delicate microsurgery for two types of procedures: free tissue transfer (moving tissue from one part of the body to another) and lymphatic surgery (to treat lymphedema, a condition causing swelling). Ab…

This study tests whether adding a special collagen thread called BioBridge to standard lymph node transfer surgery can better reduce arm swelling in people with lymphedema. About 60 adults with stage I-II arm lymphedema will be followed for 12 months to measure changes in limb vo…

This study tests whether a ketogenic diet or ketone supplements can improve lymphatic function in people with lymphedema, a condition causing arm swelling after lymph node removal. 81 participants will be randomly assigned to a ketogenic diet, an isocaloric diet, or ketone supple…

This early-stage study is testing a special radioactive tracer called 18F-FTHA that can be seen on PET scans. The goal is to learn how this tracer travels through the lymphatic system in healthy volunteers and in people with suspected blockages in the main lymph duct. The study w…

This study uses special ultrasound techniques to find clear differences between lymphedema and lipedema, two chronic conditions that cause leg swelling and are often hard to tell apart. Researchers will compare 75 adults—those with lymphedema, those with lipedema, and healthy vol…

This study tests a low-risk surgical procedure called LYMPHA, done at the same time as breast cancer lymph node removal, to prevent lymphedema—a chronic, painful arm swelling. About 80 women undergoing breast cancer surgery will be randomly assigned to receive LYMPHA or standard …

This study looks at whether doing a lymphovenous bypass procedure at the same time as lymph node removal surgery can prevent lymphedema (chronic leg swelling). Twenty adults having groin lymph node surgery will get the bypass and be followed for 2 years. The main goal is to see i…

This study tests whether a procedure called lymphovenous bypass, done before underarm lymph node removal, can prevent lymphedema (arm swelling) in patients with breast cancer or melanoma. About 252 participants will receive the bypass during their cancer surgery. Researchers will…

This study tests a procedure called Immediate Lymphatic Reconstruction (ILR) done during breast cancer surgery to prevent lymphedema, a painful arm swelling. About 98 high-risk women will be randomly assigned to receive ILR or standard care. Researchers will track who develops ly…

This study tests if repairing the lymphatic system during breast cancer surgery can prevent lymphedema, a painful arm swelling. 50 women with breast cancer will receive this reconstruction. The goal is to see if this approach reduces the risk of developing lymphedema.

This study tests a surgical technique called immediate lymphatic reconstruction (ILR) done at the same time as lymph node removal for cancer. The goal is to reconnect tiny lymph channels to nearby veins to prevent lymphedema, a painful arm swelling. Researchers will measure arm s…

This study tests a surgical procedure called immediate lymphatic reconstruction (ILR) done at the same time as lymph node removal in breast cancer patients. The goal is to prevent lymphedema, a painful arm swelling that can occur after surgery. Researchers will follow 100 women t…

This study tests a surgery called lymphovenous bypass (LVB) to prevent lymphedema—painful arm swelling—in breast cancer patients who had lymph nodes removed. About 136 participants will either get LVB plus physiotherapy or physiotherapy alone. The goal is to see if the surgery re…

This study tests whether a comprehensive program can prevent lymphedema (chronic arm swelling) in women undergoing lymph node removal for breast cancer. The program includes immediate lymphatic reconstruction during surgery, self-directed lymphatic massage, and regular arm measur…

This study looks at whether doing resistance exercises (like leg presses) can reduce swelling in the lower legs of people with lymphedema. It also checks if wearing compression garments during exercise makes a difference. Thirty-six adults with lower limb lymphedema will exercise…

This study tests whether a device that delivers sound waves (shock wave therapy) can help reduce leg swelling and improve quality of life in people with lower limb lymphedema. Thirty-six adults who are already using standard care will either get real or fake (sham) treatments twi…

This study tests whether a structured self-management program can help head and neck cancer survivors cope with lymphedema and fibrosis, which cause swelling and stiffness after treatment. Participants will either follow their usual care or learn the program in person or through …

This trial tests whether two physical therapies—Kinesio Taping and compression therapy—can relieve breast lymphedema, a common side effect of breast-conserving surgery and radiation that causes swelling, pain, and heaviness. About 99 women who have completed radiation and have ul…

This study compares two ways to treat breast cancer that has spread to nearby lymph nodes: targeted radiotherapy or surgical removal of the nodes. The goal is to see which approach better preserves arm function and reduces the risk of long-term arm swelling. About 1,060 adults wi…

This study tests whether adding specific shoulder and posture exercises to standard lymphedema treatment can improve arm function, muscle strength, and posture in women who developed arm swelling after breast cancer surgery. Participants are randomly assigned to receive either st…

This study tests whether adding breathing and relaxation exercises to standard lymphedema therapy can improve walking ability and muscle oxygen levels in women with leg swelling. Participants receive either standard therapy alone or standard therapy plus a structured breathing an…

This study compares two types of nerve blocks (pectoral nerve block vs. paravertebral block) given during mastectomy to see which better prevents chronic pain. Ninety women aged 20-65 undergoing mastectomy will be randomly assigned to one of the two blocks. The goal is to reduce …

This study tests a light-based treatment (photobiomodulation) to reduce long-term swelling in the head and neck area caused by cancer therapy. It involves 150 adult survivors who have had head and neck cancer and still have swelling for at least 6 months. Participants will receiv…

This study looks at two types of nerve blocks given before mastectomy to see which one better prevents chronic pain. About 132 adults having a mastectomy will be randomly assigned to receive either an erector spinae block or a paravertebral block. Researchers will track pain, opi…

This study tests if combining resisted deep breathing exercises with a special massage technique (myofascial release) can reduce pain, improve breathing, chest movement, and arm swelling in people who have had a mastectomy. The study will include 48 adults who are at least 6 mont…

This study is testing a new portable device called Dayspring that uses active compression to reduce leg swelling from lymphedema or phlebolymphedema. It will involve 100 veterans and measure cost savings, mobility, and symptom severity. The device is non-pneumatic, meaning it doe…

This study tests whether two non-invasive therapies—extracorporeal shock wave therapy and pulse electromagnetic field therapy—can reduce swelling and improve quality of life in people with lymphedema after cancer treatment. Ninety participants will receive one of the therapies or…

This study tests whether adding virtual reality (VR) exercises to standard therapy can improve walking, reduce leg swelling, and boost quality of life in people with lower limb lymphedema. Forty adults with stage 2 or 3 lymphedema after cancer surgery will either receive standard…

This study tests a surgery called lymphaticovenous anastomosis (LVA) to see if it reduces chronic swelling (lymphedema) in cancer survivors. About 110 people with swelling in one arm or leg after cancer treatment will be randomly assigned to receive either LVA or a sham surgery. …

This study tests a special massage technique called 'Gentle Touch' to see if it can reduce arm swelling (lymphedema) in women who had breast cancer surgery. Thirty-six women aged 30 to 75 will receive either Gentle Touch or standard care twice a week for five weeks. The goal is t…

This study compares two standard pain-block methods for people having a mastectomy (breast removal) due to breast cancer or high risk. One method uses a nerve block before surgery, the other during surgery. The goal is to see which approach reduces the need for opioid painkillers…

This study tests whether a special massage called manual lymph drainage can help reduce swelling in the face and neck caused by radiation therapy for head and neck cancer. The study will include 40 people who have finished radiation within the past year. It compares two different…

This study compares the gut microbiota of people with lymphedema who have had repeated soft tissue infections to those who have not. Researchers will analyze stool samples from 60 participants to see if certain bacteria are more common in the infection-prone group. The goal is to…

This study checks if people with lymphedema have higher levels of lipoprotein(a), a substance linked to heart disease. Researchers will test blood from 100 adults with lymphedema to see how common high LP(a) is. The goal is to learn if lymphedema patients need extra heart risk mo…

This study watches how the lymphatic system changes after radiation therapy in 40 women with breast cancer. Researchers use a safe dye and special camera to see early signs of arm swelling (lymphedema). The goal is to find ways to predict and prevent this side effect in the futur…

This pilot study tests whether a new compression pattern in a leg sleeve device (Flexitouch Plus) moves lymph fluid better than the current version. Five adults with leg lymphedema will receive both treatments in separate visits, and doctors will measure how far and how often lym…

This natural history study aims to collect data from 1,200 people with lymphatic anomalies—rare conditions affecting the body's lymph system—over many years. Researchers will track symptoms, perform genetic testing, and gather biospecimens to better understand why these condition…

This study follows breast cancer patients who are receiving targeted therapy to see if they develop arm swelling, known as lymphedema. Researchers use two devices—a Perometer and a SOZO device—to measure changes in arm volume and fluid levels. The goal is to detect lymphedema ear…

This study follows 1,250 women who have had lymph node removal during breast cancer surgery. Researchers use arm measurements and tissue tests to see who develops lymphedema (arm swelling) and why. The goal is to find early warning signs and improve quality of life.

This study explores whether a device that sends a tiny, safe electrical current through the body can better track fluid retention (edema) in cancer patients. Researchers will measure 46 people—breast cancer patients with arm swelling after radiation and others with leg swelling a…

This study follows 100 women with early-stage breast cancer for two years after surgery and treatment. Researchers will measure changes in muscle mass, body fat, and strength using simple tests. The goal is to understand how the body recovers and what factors affect quality of li…

This study follows 400 pregnant women with rare blood vessel diseases (like HHT, Marfan syndrome, or lymphedema) to learn about serious pregnancy complications. Researchers will ask participants about their health during pregnancy and for 12 months after birth. The goal is to gat…

This study follows 400 patients who have had urologic cancer surgery with lymph node removal to see how often they develop lymphedema (leg swelling). Researchers will use questionnaires and special devices to measure swelling and tissue fluid over two years. The goal is to better…

This study aims to understand why lymphedema develops by comparing gene activity in swollen versus healthy limbs. Researchers will take tiny tissue samples from 60 adults with primary or secondary lymphedema. The goal is to identify molecular differences that could point toward f…

This study follows 10,000 breast cancer patients to detect lymphedema—arm swelling that can occur after treatment—as early as possible. Researchers use arm measurements and patient surveys to track changes in symptoms, function, and quality of life. The goal is to improve outcome…

This study is creating a collection of blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. Researchers will use these samples to study inflammation, blood clotting, and other biological pathways. The goal is to build a resource tha…

This study looks at 48 people with chronic leg swelling to find out why some respond to compression therapy and others don't. Participants will have an MRI and genetic testing to measure fat, muscle, and fluid in their legs. The goal is to better understand the condition, not to …

This study follows 600 people with lymphedema to compare quality of life between those who choose surgery (a lymph node transfer) and those who choose non-surgical management. Participants fill out questionnaires about their symptoms and daily life over time. The goal is to under…