Hyperglycemia

Researchers test whether continuous glucose monitors (CGM) can help hospitalized adults with type 2 diabetes reach a tighter average blood sugar target of 90 to 130 mg/dL without causing dangerous low blood sugar. Participants are randomly assigned to standard care (target 140 to…

This study tests whether choosing diabetes medications based on a person's genetic profile helps control blood sugar better than standard treatment. About 500 adults with type 2 diabetes that is not well controlled will be randomly assigned to either gene-guided or standard care.…

This trial tests whether taking coenzyme Q10, a natural antioxidant, for 12 weeks can improve blood sugar control and markers of brain health in people with mild cognitive impairment or Alzheimer's disease who also have high blood sugar. Participants will take either the suppleme…

This trial tests a smart insulin pump algorithm designed to automatically adjust insulin delivery during the night to keep blood sugar levels in a safe range. The algorithm predicts when blood sugar might drop too low and pauses insulin, and when it might rise too high, it gives …

This trial asks whether cooking with refined high-oleic palm oil can improve cholesterol and blood sugar levels as effectively as olive oil. Healthy adults will be randomly assigned to use one of the two oils in their daily cooking for four months. Researchers will measure change…

This study tests whether treating low blood sugar (hypoglycemia) at a slightly lower threshold of 65 mg/dL, instead of the standard 70 mg/dL, can prevent rebound high blood sugar in children with type 1 diabetes. Each child undergoes both approaches in a crossover design, receivi…

This trial tests whether a continuous glucose monitor (CGM) — a small sensor worn on the arm — can help manage blood sugar levels more effectively than standard fingerstick checks in critically ill sepsis patients. Sepsis patients often have unstable blood sugar, which can lead t…

This trial compares continuous glucose monitoring (CGM) with standard fingerstick testing in 400 critically ill ICU patients with high blood sugar. CGM uses a small sensor under the skin to measure glucose every 5 minutes and alerts staff when levels are too high or low. The goal…

This study investigates whether drinking galactose before cycling can prevent low blood sugar (hypoglycemia) in people with type 1 diabetes. Fourteen participants will try four different drinks—dextrose, galactose, lactose, or a sweetened placebo—on separate days, then cycle for …

This study tested a 6-week diabetes self-management program for ethnic minority elderly (aged 60+) in rural Thailand. The program included weekly group sessions on diet, exercise, medication, and emotional coping, plus two home visits. Researchers measured changes in blood sugar …

This study tested two long-acting insulins, glargine and degludec, in 79 hospitalized adults whose blood sugar became high due to steroid medications. The goal was to see which insulin better controls blood sugar with fewer dangerous lows. Results help doctors choose the safest a…

This study tested a virtual health program for African immigrants aged 25-75 who had at least two risk factors like diabetes, high blood pressure, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over 6 months. The program was deliv…

This study tested whether special cookies made from Golden Rice and an herb called Piper crocatum could lower fasting blood sugar and improve quality of life in 102 people living with HIV who also have high blood sugar. Participants ate either the Golden Rice cookies or plain con…

This completed trial tested whether taking vitamin D and calcium supplements for six weeks could improve blood sugar and cholesterol levels in 60 pregnant women diagnosed with gestational diabetes. The study measured fasting blood sugar, HbA1c, and lipid profiles to see if the su…

This pilot study tested whether giving a mix of glucose, insulin, and potassium (GIK) during abdominal surgery can reduce serious complications in patients who do not have diabetes. About 106 adults took part to see if the treatment is practical and safe. The goal is to plan a la…

This study looked at whether replacing breakfast with a low glycemic index shake helps overweight and obese adults manage their blood sugar. 46 non-diabetic adults aged 25-65 with a BMI between 25 and 40 took part. For two weeks, they either drank the shake or ate oat cereal for …

This study tested whether a continuous glucose monitor (CGM) could help nurses manage blood sugar in ICU patients receiving IV insulin. Researchers enrolled 201 adults with high blood sugar or on insulin at Ohio State University. The goal was to see if using the CGM alongside sta…

This study tested two ways to help food-insecure adults with heart risks eat more fruits and vegetables. One group got a $20 grocery credit every two weeks, the other got a box of produce delivered to their home. Researchers measured changes in diet and food security over time.

This study tested whether drinking an extra 1.5 liters of water daily for a year could lower blood sugar in adults with signs of dehydration and high blood glucose. Nearly 800 participants were split into two groups: one received lifestyle advice plus extra water, the other only …

This study tested whether taking flaxseed oil capsules (rich in alpha linolenic acid) for 24 weeks could improve blood sugar levels in 94 adults with elevated blood sugar or mild type 2 diabetes. Participants also had their gut bacteria and fatty acids measured. The goal was to s…

This completed study tested a dietary supplement called GLP-1 Booster in 69 overweight adults over 26 weeks. The supplement contains extracts from green tea, gardenia, turmeric, and other herbs, and is designed to increase the body's own GLP-1 hormone to help control blood sugar,…

This pilot trial tests whether a multi-part program given to emergency department patients with metabolic syndrome can encourage more walking and healthier habits. Participants receive a Fitbit, watch a short educational video, get a written exercise prescription, receive text re…

This study tested whether a fully automated digital program could help people with prediabetes lose weight and lower their blood sugar as effectively as a program led by a human coach. About 368 adults with prediabetes and overweight took part. The goal was to see which approach …

This study looked at whether quercetin, a natural substance found in foods like apples and onions, can change how the body absorbs sugar. Researchers gave 24 obese adults (some with type 2 diabetes) either quercetin or a placebo during a sugar-drink test. They measured blood suga…

This study tested a smartphone app called SNAQ that estimates the carbohydrate content of a meal from a single photo. The goal was to see if using the app helps people with type 1 diabetes keep their blood sugar in a healthy range. 44 adults who already use an automated insulin p…

This study looked at 8 adults with metastatic breast cancer who were starting the drug alpelisib. Alpelisib often causes high blood sugar, so researchers used a continuous glucose monitor (a small sensor worn on the arm) to track glucose levels day and night for at least 3 months…

This study looked at whether exercising in the morning or evening helps control blood sugar better in pregnant women with gestational diabetes or glucose intolerance. 39 women walked or stepped for 30 minutes either after breakfast or after dinner. The researchers measured blood …

This study tested whether using nerve blocks and sedation instead of general anesthesia could make upper leg amputation surgery safer for high-risk patients, such as the elderly or those with diabetes or heart disease. Thirty participants received ultrasound-guided nerve blocks a…

This trial tests whether a single dose of the antipsychotic drugs olanzapine or ziprasidone changes how the body responds to insulin, compared with a placebo. The study enrolls healthy young men who are overweight or have early signs of insulin resistance, but who have never take…

This trial investigates how replacing animal proteins with plant proteins in the diet influences metabolism. Adults with early signs of metabolic syndrome (like high triglycerides or slightly elevated blood pressure) will follow a controlled diet for four weeks, either predominan…

This study investigates why some people on low-carb diets experience unexpectedly high blood glucose. Researchers measure hormones like glucagon and insulin after participants drink carbohydrate, protein, or fat beverages. The goal is to understand how different nutrients affect …

This study investigates why athletes with type 1 diabetes often experience higher blood sugar during competitions compared to regular training. Researchers will monitor 12 athletes with type 1 diabetes and 12 healthy athletes during a 5K race and a 5K training session, measuring …

This completed study in India looked at 362 hospital patients to understand how common high blood sugar (hyperglycemia) is and how it affects their hospital stay. Researchers measured blood sugar levels, checked for diabetes, and looked at body composition and certain blood marke…

This completed study looked at 192 adults with acute ischemic stroke to see if large swings in blood sugar (glycemic variability) are linked to worse outcomes, including death and disability. Participants wore a continuous glucose monitor for 96 hours. The goal was to understand …

This study looked at whether certain gene changes (in the TCF7L2 gene) make ICU patients with organ failure more likely to develop high blood sugar. Nearly 1,000 adults in the ICU were checked for these gene changes and their blood sugar levels. The goal was to understand the lin…

This study looked at 42 infants who had surgery for a rare birth defect called esophageal atresia type III. Researchers gave the babies a sugary drink to see how often they developed dumping syndrome, a condition causing rapid blood sugar changes. The goal was to find out how com…

This completed trial tested whether electronic alerts in the emergency room can improve care for people with type 2 diabetes. The alerts prompted doctors to order an A1c test when blood sugar was very high, and to consider admitting the patient for better diabetes management. Res…

This study looked at how blood sugar levels change in hospitalized babies with intestinal failure when their intravenous nutrition is given in cycles instead of continuously. Nine infants wore a small sensor on their thigh that measured glucose every 5 minutes for up to 30 days. …

This pilot study tested whether continuous glucose monitors (CGMs) can help manage blood sugar in hospitalized adults with diabetes. Forty patients wore a Dexcom G6 device during their hospital stay to track glucose levels. The goal was to see if CGM could reduce dangerous low or…

This completed study explored the link between blood sugar levels and heart rate variability in 20 critically ill patients without diabetes. Researchers wanted to understand how stress-related high blood sugar (stress hyperglycemia) relates to the body's nervous system. The study…

This study tested whether continuous glucose monitors (CGMs) can reliably track blood sugar levels in newborns at risk of low blood sugar (hypoglycemia) during their first 72 hours. Researchers enrolled 25 babies born large for gestational age or to mothers with diabetes. The goa…

This completed study looked at how blood sugar levels affect sleep in 30 adults with cystic fibrosis-related diabetes. Participants wore devices at home to track glucose and sleep for 10 days. The goal was to see if this kind of remote monitoring is practical and to gather early …

This study looked at 62 people with type 1 diabetes to see if a test that measures the hormone glucagon can predict the risk of dangerously low blood sugar (hypoglycemia). Participants drank a special liquid meal or received an arginine injection to stimulate glucagon release, an…

This study looked at whether chemicals in the breath (VOCs) match blood sugar levels in people with type 2 diabetes. Twenty adults with diabetes had their breath and blood sugar measured after drinking sugar water and receiving insulin. The goal was to see if a breath test could …

This pilot study tested whether giving metformin around the time of hip or knee replacement surgery is practical and helps control blood sugar. Forty adults took either metformin or a placebo for two weeks before surgery and a few days after. The main goal was to see if a larger …

This completed study followed 1,290 adults with type 1 or type 2 diabetes for two years. Researchers tracked mental health issues like depression, anxiety, and eating problems alongside daily blood sugar levels using smartphone surveys and continuous glucose monitors. The goal wa…

This study tested whether adding the nutrients phosphorus and lysine to white bread could improve how the body handles blood sugar and energy use after eating. Sixteen healthy adults ate different fortified breads, and researchers measured their blood sugar, insulin, and energy e…

This study looked at 100 ICU patients to see if a continuous glucose monitor (CGM) works as well as standard fingerstick tests for tracking blood sugar. The goal was to find out if CGM is reliable enough to use in the ICU. Results will help doctors decide if this technology can i…

This study looked at how well a continuous glucose monitor (CGM) works in critically ill patients with high blood sugar. Researchers placed a small sensor on the skin of 55 ICU patients to measure glucose every 5 minutes for up to 7 days. They compared these readings to standard …

This study placed a continuous glucose monitor (CGM) on 24 preterm infants born before 31 weeks to track their blood sugar levels for up to 10 days. The goal was to see how well the device detects high and low blood sugar, and to link those readings to the babies' growth and brai…

This completed study looked at how two gut hormones, GIP and GLP-1, affect the body in people who have had their pancreas removed. Researchers gave these hormones alone and together to 12 participants to measure changes in blood sugar, fat, and bone markers. The goal was to under…