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Can a common diabetes drug help after joint surgery? small study aims to find out

NCT ID NCT06280274

Knowledge-focused Sponsor: Oregon Health and Science University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tested whether giving metformin around the time of hip or knee replacement surgery is practical and helps control blood sugar. Forty adults took either metformin or a placebo for two weeks before surgery and a few days after. The main goal was to see if a larger trial is possible, not to prove metformin works.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Metformin
What this could lead to
If this pilot shows it's feasible, it could lead to a larger trial testing whether metformin helps control blood sugar after joint replacement surgery.
What could go wrong
This is a small pilot study with only 40 people, so results may not apply broadly. It focuses on feasibility, not on proving metformin works for blood sugar control.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

40 people

The number who actually took part.

Started

Jun 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 99 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female, age 18-99 years * Undergoing total hip or total knee arthroplasty, including elective, primary, and revision surgeries * Ability to take oral medication and be willing to adhere to the prescribed metformin regimen regardless of current, past, or no metformin use. Note: Patients with or without type 2 diabetes are considered eligible. (E.g.) * Type 2 diabetic on metformin * Type 2 diabetic on metformin and other medication, including insulin * Type 2 diabetic on medication but not metformin * Pre-diabetic * Non-diabetic Exclusion Criteria: * Advanced renal insufficiency (glomerular filtration rate (GFR) \< 45, or chronic kidney disease (CKD) stage 3B or higher) * Advanced liver cirrhosis or failure (Child-Pugh class B or C) * Congestive heart failure (New York Heart Association (NYHA) class 3 or 4) * Current alcohol abuse within 30 days of surgery (\>4 standard servings daily for men, \>3 standard servings daily for women) * Type 1 diabetes * Received contrast dye within 48 hours of surgery * Vulnerable populations: Children, pregnant women, neonates, decisionally impaired adults, prisoners

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Conditions

The condition(s) this trial relates to.

hyperglycemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hyperglycemia

Contacts and locations

Locations

  • Oregon Health & Science University

    Portland, Oregon, 97239, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.