Oregon Health And Science University

This study compares personalized surgery guided by a sleep endoscopy to standard tonsillectomy for treating obstructive sleep apnea in 303 children with Down syndrome, ages 2 to 17. Sleep apnea is very common in these children and often doesn't improve with standard treatments. T…

This study looks at whether patients with a thickened heart muscle condition can safely switch from one medication (mavacamten) to a newer one (aficamten). About 40 adults currently taking mavacamten will be monitored for side effects and heart function changes. The goal is to se…

This study looks at two hormone treatments—a hormonal IUD and a daily pill—to see which works better for heavy menstrual bleeding in people aged 10-24 with inherited bleeding disorders like von Willebrand disease. About 300 participants will use one of the treatments for 6 months…

This study tests whether giving the heart medication amiodarone one cycle earlier than usual during a cardiac arrest can help restore a normal heartbeat faster. About 585 adults who have a shockable heart rhythm after a cardiac arrest outside the hospital will take part. Research…

This study looks at whether adding addiction counseling and a community peer helper to regular primary care helps people with opioid use disorder stay on their medication (buprenorphine) and keep coming to their doctor visits. About 70 adults with opioid dependence and other medi…

This study tests whether a personalized surgical approach, guided by a sleep endoscopy, works better than standard tonsillectomy for children aged 2-17 with sleep apnea and small tonsils. About 240 children will be randomly assigned to one of the two surgeries. The goal is to see…

This study tests a laser procedure called custom corneal cross-linking (CXL) for people with keratoconus, a condition that thins and bulges the cornea, causing blurry vision. The treatment uses a laser guided by OCT imaging to smooth the cornea and strengthen it. Researchers will…

This study tests whether the drug guselkumab can heal painful skin ulcers in people with pyoderma gangrenosum. Seventeen adults with at least one ulcer will receive the drug and be checked at weeks 6, 16, and 32. The main goal is to see if the ulcer fully closes by week 32.

This study tests whether a sugar called L-fucose can improve movement problems in adults with GLUT1 deficiency syndrome, a rare genetic disorder that affects brain energy. Sixteen participants will receive both the supplement and a placebo in random order, without knowing which t…

This study is testing a new imaging method using a special tracer called I-124 evuzumitide to better diagnose cardiac amyloidosis, a condition where abnormal proteins build up in the heart and other organs. About 150 adults with known or suspected amyloidosis will receive a PET/M…

This study aims to improve how doctors detect and treat irregularly shaped corneas caused by conditions like keratoconus, dry eye, and scars. Researchers will use a special imaging technique called optical coherence tomography (OCT) to create a better classification system and gu…

This study tests whether wearable sensors that give real-time audio or visual feedback during physical therapy can help people with mild traumatic brain injury (concussion) recover balance and movement better than standard therapy. The study will enroll 100 adults who are still h…

This study tests whether freezing the nerve (cryoablation) plus a standard steroid and numbing injection works better than the injection alone for Morton's neuroma, a painful foot nerve condition. About 32 adults who haven't improved with basic treatments like orthotics will be e…

This study tests a video-based program called STELLA-FTD for family members caring for a loved one with frontotemporal dementia (FTD). The program helps caregivers manage difficult behaviors and connect with support resources. Researchers will measure changes in caregiver burden …

This study tests whether balance exercises done at home with wearable sensors can help older adults with Parkinson's disease improve their stability and reduce fall risk. Researchers will enroll 80 people aged 55-85 with mild to moderate Parkinson's. Participants will be guided r…

This study tests whether injecting lidocaine into the abdominal wall can reduce chronic pain caused by a trapped nerve. About 45 adults with persistent belly wall pain will receive the injection as part of their normal care and report their pain levels over three months. Research…

This study tests whether a small, at-home device that stimulates a nerve in the ankle can help women in rural areas manage overactive bladder symptoms. About 38 women will use the device themselves and report changes in bladder control and quality of life. The goal is to find a s…

This study tests an online program called STELLA-R that teaches caregivers of people with dementia how to better handle difficult behaviors like agitation or aggression. The program uses a simple ABC method to understand what triggers these behaviors and how to respond. About 238…

This study tests a short sleep program for children ages 3 to 7 who have trouble falling asleep on their own. The program teaches good sleep habits and uses a "Bedtime Pass" to help kids stay in bed. It is designed to be given by a health consultant during regular doctor visits. …

This study compares a home pelvic floor physical therapy program to standard care for 30 women having endometriosis surgery (without hysterectomy). The goal is to see if the home program improves pelvic pain and quality of life during recovery. Participants will complete surveys …

This study tests whether a newer, directional form of deep brain stimulation (DBS) can better control essential tremor while reducing side effects like speech and balance problems. About 24 adults with essential tremor will receive both directional and standard DBS to compare the…

This study looks at how sleep and the body's internal clock influence blood pressure in people with hypertension. Researchers will monitor 32 adults aged 25-64 to understand why some people's blood pressure doesn't drop enough at night. The goal is to uncover mechanisms behind th…

This study tests whether a special eye-imaging technology (OCT) can help fit scleral contact lenses better than the current method. About 258 people with conditions like keratoconus or post-surgery corneal irregularities will have two lens fittings—one using standard methods and …

This study tests whether a small, wearable device that vibrates in time with each step can help people with Parkinson's disease walk more automatically and steadily. Researchers will measure brain activity and walking patterns in 60 participants as they use either personalized or…

This study is observing 640 pregnant people to build a tool that can predict placental insufficiency—a condition where the placenta doesn't work well enough. The goal is to catch problems early and prevent serious outcomes like stillbirth or poor growth. Participants will be foll…

This study tests whether morning bright light therapy can improve sleep in 300 veterans with traumatic brain injury. Researchers will measure changes in inflammation, cell energy, and brain waste-clearing function. The goal is to understand how better sleep might support overall …

This study uses a special camera (OCT) to measure swelling in the clear front part of the eye (cornea) in people with Fuchs' dystrophy or a related condition. Researchers want to see if these measurements can predict how vision changes after surgery. About 60 adults with corneal …

This study looks at iris tumors (growths in the colored part of the eye) using a special imaging technique called OCT angiography. Researchers will compare images from healthy eyes and eyes with tumors to see if this method can better tell benign from malignant growths. About 100…

This study looks at how eating a high-fat diet can change the timing of your body's internal clock. Researchers will track 14 healthy, lean adults over 46 days, including 18 days spent in a research center. The goal is to understand how quickly the body's clock adjusts to a high-…

This study uses special eye cameras to look for blood vessel changes and protein deposits in the retina of people with Alzheimer's or mild dementia. Researchers will compare these eye scans to those of healthy older adults. The goal is to find a simple, noninvasive way to spot ea…

This study looks at how a drug that blocks a natural hormone (GnRH) affects cervical mucus at four points during the menstrual cycle. Fifteen healthy women with regular cycles will give blood, mucus, tissue, and vaginal swab samples. The goal is to understand mucus changes at the…

This study looks at how keeping a consistent sleep schedule affects heart health and metabolism in healthy adults aged 18-40, and also in people with chronic pain. Over 12 weeks, researchers will track sleep patterns and measure things like blood pressure, heart rate, and blood s…