Chronic periodontitis

This trial tests whether adding a laser procedure to standard deep cleaning improves gum health and quality of life in people with periodontitis. Researchers will compare two groups: one receiving scaling and root planing alone, and another receiving the same cleaning plus laser-…

This study tests whether a gel made from cross-linked hyaluronic acid (Hyadent BG®) can help regrow bone and gum tissue destroyed by chronic gum disease, comparing it to a standard treatment called Emdogain®. About 53 adults with moderate periodontitis will receive one of the two…

This trial tests whether treating gum disease can reduce bacteria that cause lung infections in people with bronchiectasis. Participants with both conditions will receive either basic cleaning, deep cleaning, or deep cleaning plus light therapy. Researchers will measure bacteria …

This study tests a procedure called intentional replantation for single-rooted teeth that are considered hopeless due to advanced gum disease. Researchers will remove the tooth, treat it outside the mouth, and put it back in the socket. They will track bone healing, pain, and too…

This study compares a new, less invasive gum surgery (NIPSA) alone versus the same surgery plus a bone graft and platelet-rich fibrin to repair deep bone defects caused by advanced periodontitis. The trial enrolls adults with stage III periodontitis who have at least one deep gum…

This study tested whether adding ozonated olive oil gel or curcumin gel to standard deep cleaning helps treat gum disease (stage II grade B periodontitis). Forty adults completed the 3-month trial. Researchers measured gum attachment levels, plaque, and inflammation to see which …

This study tested whether adding a light-based antibacterial treatment called photodynamic therapy (PDT) to standard deep cleaning improves gum health in people with moderate gum disease. Thirty adults received standard cleaning on one side of the mouth and standard cleaning plus…

This study tested whether adding platelet-rich fibrin (a concentrate from your own blood) plus the antibiotic minocycline works better than the antibiotic Arestin alone for treating gum disease. Fifteen adults with moderate gum disease received both treatments in different parts …

This study tested a special food-grade formula applied to the gums in 20 adults with chronic gum disease. Researchers observed that gum redness and bleeding improved within 7 to 14 days. The approach aims to repair gum tissue without surgery, but larger and more rigorous studies …

This study looked at whether eating an amla berry (Indian gooseberry) along with standard deep cleaning helps people with chronic gum disease more than cleaning alone. Thirty adults with moderate to severe gum disease were split into two groups: one got cleaning plus amla, the ot…

This study tested a home-use device that uses dual-light therapy and a special mouth rinse to help control chronic gum disease. Fifty-six adults with advanced periodontitis used the device regularly. The goal was to see if it reduces gum bleeding and improves plaque control, whic…

This study tested a new ultrasonic device with root polishing against standard scaling and root planing for treating gum disease. Forty adults with moderate to severe gum disease were treated and followed for 6 months. The goal was to see which method better reduced pocket depths…

This study tested whether adding laser therapy to standard deep cleaning improves gum health in people with severe periodontitis. Twenty adults received either antimicrobial photodynamic therapy (using a blue dye and laser) or photobiomodulation (red or infrared laser) alongside …

This study tested whether platelet-rich fibrin (PRF), made from a patient's own blood, can improve gum and bone regeneration after standard periodontal surgery. Sixty adults with chronic gum disease and bone defects were randomly assigned to surgery alone or surgery plus PRF. Res…

This study tested a light-activated treatment called Fotosan®630 for severe gum disease (periodontitis). The goal was to see if it could reduce deep gum pockets and infection better than standard care. The trial involved 36 adults with severe chronic periodontitis and followed th…

This study tested if a special light device used at home can help manage chronic periodontitis, a serious gum infection. 202 adults with gum disease used the device regularly to see if it reduced bleeding and improved gum health. The goal was to offer an easy, non-invasive way to…

This study tested whether a gel made from patients' own blood (injectable platelet-rich fibrin, or i-PRF) could improve healing after standard gum surgery for periodontitis. 42 adults with deep gum pockets received surgery alone or surgery plus i-PRF and a root-cleaning gel. Rese…

This study tested two antibiotic gels (metronidazole and minocycline) in 380 adults with both diabetes and gum disease. Participants received deep cleaning alone or with one or both gels. Researchers checked gum pocket depth and gum color/texture at 7 and 15 days to see which tre…

This study tested two treatments for deep gum bone defects caused by periodontitis: platelet-rich fibrin (PRF), made from the patient's own blood, and enamel matrix derivative (EMD), a protein gel. Twenty-six patients received one of the treatments after surgery, and their gum he…

This study tested a new mouth rinse made with coconut oil and xylitol to see if it could improve gum health in people with periodontitis. 120 adults used the rinse or a placebo three times a day for three weeks. Researchers measured gum appearance and bleeding before and after us…

This study tested two ways to clean teeth and gums in 82 people with poorly controlled type 2 diabetes and severe gum disease. One method cleaned all teeth in one day (full mouth disinfection), while the other cleaned one quarter of the mouth at a time over four weeks. Researcher…

This study investigates whether proteins from the Hippo signaling pathway—known to control cell growth and bone health—are present at different levels in the gum fluid of people with healthy gums, gingivitis, or periodontitis. Researchers will collect fluid samples from 75 partic…

This study looks at how smoking and gum disease (periodontitis) affect certain proteins and genetic markers in the body. Researchers will compare these markers in smokers and non-smokers with and without gum disease, before and after a standard deep-cleaning treatment. The goal i…

This study followed 55 people with dental implants for 5 years to see if their history of gum disease (aggressive, chronic, or none) affected implant health. Participants received regular dental cleanings. Researchers measured bone loss, gum inflammation, and implant survival. Th…

This study translated a questionnaire that measures how chronic gum disease affects quality of life into Hindi. Researchers tested it on 196 patients with periodontitis to ensure it is accurate and reliable. The goal is to give Hindi-speaking patients a way to report their oral h…

This study tested a new lab method (xCELLigence system) to grow oral biofilms and select the most effective antibiotic for each patient with chronic periodontitis. 64 adults with severe gum disease received standard deep cleaning plus an antibiotic chosen by the new test. The goa…

This study examined fluid from deep gum pockets in 30 people with severe periodontitis, both smokers and non-smokers. Researchers measured 40 inflammatory markers before and after non-surgical deep cleaning. The goal was to see which markers change with treatment and whether smok…

This study looked at 185 people to compare inflammation markers in those with tooth infections (apical periodontitis), gum disease (chronic periodontitis), and healthy gums. Researchers measured substances like TNF-α and PGE2 in blood and gum fluid. The goal was to better underst…

This pilot study looked at whether certain natural germ-fighting proteins, called antimicrobial peptides, are linked to chronic gum disease. Researchers collected gum smears from 29 adults with moderate to severe periodontitis and from healthy people to compare gene activity. The…

This study measured levels of three metals—chromium, nickel, and magnesium—in the blood of 74 adults. Some had type 2 diabetes and gum disease, some had only one condition, and some were healthy. The goal was to see if these metals are connected to gum health in people with diabe…

This study measured levels of a protein called NLRP6 in the blood of 50 adults with chronic periodontitis (long-term gum disease). Researchers wanted to see if NLRP6 levels are linked to gum health. The study is complete and aimed at understanding the disease better, not testing …

This completed study looked at two ways to clean below the gumline in 80 adults with early-stage gum disease. One group received Guided Biofilm Therapy, a newer technique, while the other got conventional cleaning with hand tools and an ultrasonic device. Researchers measured gum…