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New lab test could take the guesswork out of antibiotic choice for gum disease

NCT ID NCT03863249

Knowledge-focused Sponsor: University of Valencia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new lab method (xCELLigence system) to grow oral biofilms and select the most effective antibiotic for each patient with chronic periodontitis. 64 adults with severe gum disease received standard deep cleaning plus an antibiotic chosen by the new test. The goal was to see if this approach improves clinical outcomes like pocket depth and bleeding. The study is complete, but results are not yet reported.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
antibiotics (amoxicillin, metronidazole, azithromycin)
What this could lead to
If successful, this could lead to a faster, more accurate way to choose antibiotics for gum disease, potentially improving outcomes and reducing antibiotic resistance.
What could go wrong
This is a small, completed Phase 4 trial focused on developing a lab test, not testing a new treatment. The method may not prove better than current practice in larger, real-world settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

64 people

The number who actually took part.

Started

Feb 2019

Finished

May 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Subjects of 40-70 years. 2. No smokers or smokers of less than 10 cigarettes a day. 3. Patients with periodontitis stages III and IV grades A-B. 4. Presence of 20 natural teeth, including at least three molar teeth. 5. Presence of at least 4 sites with at least 6 mm probing depth. 6. Good general health Exclusion Criteria: 1. Smokers of more than 10 cigarettes a day. 2. Patients who have received periodontal treatment in the previous 12 months. 3. Patients who have used antibiotics in the last 6 months. 4. Routine use of oral antiseptics and / or during the previous 3 months. 5. Systemic conditions that required antibiotic premedication. 6. Women pregnant or nursing. 7. Medications that could influence the outcome of periodontal therapy. 8. Any known allergies to the test antimicrobial agents. 9. Diabetics.

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Conditions

The condition(s) this trial relates to.

Alveolar Bone Loss chronic periodontitis Dental Plaque Dysbiosis periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic periodontitis Periodontal bone loss Resistance bacterial

Contacts and locations

Locations

  • Marta Reglero Santaolaya

    Valencia, Valencia, 46010, Spain

More trials for these conditions

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