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Can deep cleaning reverse Smoking's toll on gum disease?

NCT ID NCT06351722

Knowledge-focused Sponsor: Necmettin Erbakan University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This study looks at how smoking and gum disease (periodontitis) affect certain proteins and genetic markers in the body. Researchers will compare these markers in smokers and non-smokers with and without gum disease, before and after a standard deep-cleaning treatment. The goal is to understand the biological links between smoking, gum disease, and inflammation, which could lead to better ways to manage gum health in smokers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Non-surgical periodontal treatment (deep cleaning)
What this could lead to
If successful, this could reveal how smoking affects the body's inflammatory response to gum disease and whether treatment can reverse those effects, potentially guiding better care for smokers.
What could go wrong
This is an observational study, so it can't prove cause and effect. The results may not apply to everyone, and the biomarkers measured may not directly reflect clinical outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

100 people

The number who actually took part.

Started

Jun 2024

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study is planned to be conducted with 100 individuals aged between 18 and 65 who apply to the Department of Periodontology, Faculty of Dentistry, Necmettin Erbakan University, for various reasons. The eligibility of individuals to be included in the study will be evaluated by Dr. Zeynep TAŞTAN EROĞLU at the Periodontology Clinic of NEU Faculty of Dentistry.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Being between the ages of 18 and 65 * Being diagnosed as "periodontally healthy" or "periodontitis" based on periodontal examination * Not having any accompanying systemic diseases (such as diabetes, cardiovascular diseases, etc.) * Agreeing to participate in the study Exclusion Criteria: * Use of contraceptive medications * Use of anti-inflammatory, antibiotic, immunosuppressive, or other medications - that could affect the study outcomes within the previous 6 months * History of excessive alcohol consumption * Pregnancy or breastfeeding * Undergoing periodontal treatment within the previous 6 months * Refusal to participate in the study

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Conditions

The condition(s) this trial relates to.

chronic periodontitis periodontitis periodontitis, chronic, adult Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis, adult

Contacts and locations

Locations

  • Necmettin Erbakan University Faculty of Dentistry, Department of Periodontology

    Konya, Turkey (Türkiye)

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