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Gum disease treatment showdown: natural blood concentrate vs antibiotic microspheres

NCT ID NCT07437209

Disease control Sponsor: Center for Advanced Rejuvenation and Esthetics Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding platelet-rich fibrin (a concentrate from your own blood) plus the antibiotic minocycline works better than the antibiotic Arestin alone for treating gum disease. Fifteen adults with moderate gum disease received both treatments in different parts of their mouth. The goal was to see which combination improves gum attachment and reduces pocket depth better.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

15 people

The number who actually took part.

Started

Dec 2024

Finished

Dec 2025

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male and Female subjects requiring non-surgical periodontal therapy• No contraindications to periodontal treatment Exclusion Criteria: * previous periodontal treatment within the past 6 months; * local or systemic antibiotic treatment within the past 3 months; * diagnosis of Stage I/ or IV periodontitis; * poor oral hygiene defined as a full-mouth plaque score \>30%; * history of radiation or immunosuppressive therapy; * presence of neurologic disorders, major mechanical obstruction to mouth opening, or acute temporomandibular capsulitis; * systemic conditions that may compromise bone metabolism or wound healing such as metabolic bone disease, uncontrolled diabetes; * history of substance abuse such as drug or alcohol; or * current pregnancy, nursing, or planning pregnancy during the study period.

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Conditions

The condition(s) this trial relates to.

chronic periodontitis cyclopia sequence periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Non-surgical periodontal therapy

Contacts and locations

Locations

  • Lakewood Ranch Dental

    Sarasota, Florida, 34240, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.