University Of Manitoba

This study tests whether giving a stronger blood thinner (heparin) to adults hospitalized with pneumonia can prevent serious complications like needing a breathing machine or dying. About 4,000 participants will be randomly assigned to receive either the blood thinner or standard…

This study tests whether eating fruits and vegetables with different potassium levels affects blood potassium in people with chronic kidney disease. About 30 adults with moderate-to-severe kidney disease will follow two diets in random order, each with home-delivered produce. Res…

This study looks at whether a minimally invasive procedure called MMA embolization can lower the chance of a subdural hematoma (a type of brain bleed) coming back. About 1000 adults with this condition will be treated and followed for 90 days. The goal is to see if the procedure …

This study tests if Dialectical Behavioral Therapy (DBT), which focuses on emotions and mindfulness, can help teens aged 14-17 with obesity improve their quality of life and manage weight to prevent type 2 diabetes. Participants will be randomly assigned to weekly group sessions …

This study compares two types of pain relief—spinal and epidural anesthesia—for people having liver surgery. The goal is to see if spinal anesthesia helps control blood pressure better and reduces the need for IV fluids after surgery, while still providing good pain control. The …

This study tests whether tranexamic acid, a drug that helps blood clots stay in place, can safely reduce bleeding in people with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML). About 75 adults receiving less-intensive chemotherapy and having low platelet counts w…

This study looks at whether different types of mild electrical brain stimulation can improve memory and thinking in people with dementia. About 200 participants will receive several rounds of stimulation combined with cognitive exercises over 4 weeks, followed by a 12-week break.…

This study tests whether a handheld canister of nitrous oxide (laughing gas) can help control pain and anxiety during burn dressing changes. Thirty adults with burns covering 5-20% of their body will try both the gas and standard care to see which works better. The goal is to fin…

This study tests a gel called PluroGel on burn injuries to see if it helps wounds heal better and reduces the need for skin grafts. Twenty adults with similar burns on both arms or legs will have one limb treated with PluroGel and the other with standard dressing. The goal is to …

This study tests a group mental health program for adults 55 and older who feel lonely, isolated, or have symptoms of anxiety or depression. The program is delivered by phone or video and teaches skills to handle difficult emotions. Researchers want to see if it improves well-bei…

This study tests a special video game controller adapter designed for one-handed use in children aged 7 to 17 who have an upper limb difference on one side. Researchers want to see if the adapter improves how well kids play and how much they enjoy gaming. Participants will try th…

This study tests a gentle brain stimulation method called tDCS to see if it can improve thinking and memory in people with Parkinson's disease who have mild cognitive issues. About 36 adults with Parkinson's will receive tDCS or a sham treatment, and their cognitive performance w…

This study tests a 4-week online course that teaches people how to manage parasomnias—unwanted events during sleep like sleep terrors, sleepwalking, and nightmares. The course provides education and self-management guidance. Researchers will measure if the course reduces how ofte…

This study tests whether different types of gentle electrical brain stimulation, combined with computer-based thinking exercises, can improve memory and thinking in people with dementia. About 100 older adults with mild to moderate dementia will receive either real or fake stimul…

This study tests whether using a virtual reality (VR) headset with a guided meditation program during a vasectomy can lower pain, anxiety, and discomfort. About 90 adult men will be randomly assigned to either use VR or receive standard care. The goal is to see if VR can make the…

This study aims to understand what helps or hinders play for children with physical disabilities. Researchers will talk to families, then give children Lego robots to build and play with for a few weeks. The goal is to create a complete model of play that doctors and therapists c…

This study tests a new wearable device that uses light to measure how well the brain controls its blood flow. Researchers will test the device on 250 healthy volunteers to see how age and sex affect brain blood flow regulation. The goal is to create a portable, non-invasive tool …

This study looks at how a gentle, non-invasive brain stimulation method called HD-tDCS changes the way different brain regions talk to each other. Researchers will measure brain activity and blood flow in 100 healthy adults before and after stimulation. The goal is to better unde…

This study looks at why many ICU patients, especially those with sepsis, develop lasting muscle weakness. Researchers will test 50 adults who were on a breathing machine for at least 7 days and have left the hospital. Participants will do exercise tests to measure heart and muscl…

This study explores whether a non-invasive device placed in the outer ear can detect brain waves (theta rhythms) linked to anxiety. Currently, measuring these signals requires surgery, but this approach could lead to a simple, wearable diagnostic tool. Healthy volunteers aged 18-…

This study aims to find genetic markers that can predict which children and youth (ages 6-24) with depression, anxiety, or OCD may experience behavioral activation—a side effect like agitation or restlessness—when taking SSRI antidepressants. Researchers will analyze DNA from 160…

This study is testing whether a simple genetic test can help doctors choose safer and more effective medications for people with mental health conditions. Researchers will enroll 200 adults in Manitoba who are starting or changing psychiatric drugs. The goal is to see if using ge…

This study follows up on children whose mothers had type 1 diabetes and took part in the CONCEPTT trial. Researchers will assess the children's thinking skills, behavior, and risk of autism using parent questionnaires. The goal is to understand how maternal diabetes during pregna…

This study aims to understand how using a medical fitness facility and daily habits like diet, exercise, and sleep affect health as people age. Researchers will collect information from 100 adults aged 30 and older who are members of the Wellness Institute in Manitoba. No treatme…