Tomsk National Research Medical Center Of The Russian Academy Of Sciences

This study looked at 100 people with hypertrophic cardiomyopathy, a condition where the heart muscle thickens and blocks blood flow. Researchers compared different surgical techniques—removing part of the thickened heart muscle alone or combined with repairing the mitral valve—to…

This small, completed Phase 1 study tested a single injection of a radioactive drug called Lutetium-177 BQ7876 in 7 men with prostate cancer. The main goals were to see how the drug spreads in the body, how much radiation reaches tumors, and whether it is safe. Because it is very…

This study looked at whether follow-up visits by phone or video are as safe as in-person visits for people who had a heart attack and received a stent. 88 patients were split into two groups: one had telemedicine check-ups at 1, 3, and 6 months, and the other had standard office …

This completed trial tested whether giving epinephrine and verapamil directly into the heart arteries could help restore blood flow in heart attack patients whose vessels remain blocked despite standard treatment. 104 adults with ST-elevation heart attacks were enrolled. The stud…

This study tested whether sending personalized text messages about lifestyle changes could improve heart health in 700 people who had a stent placed for coronary artery disease. Half received 4 texts per week for 24 weeks, while the other half got standard care. Researchers measu…

This study tested a combined treatment using air-plasma flow and nitric oxide gas to prevent and treat wound infections after heart surgery. It included 80 patients with mediastinitis, a serious chest infection. The goal was to see if this approach could reduce infection, improve…

This study tests two new radioactive imaging agents, 99mTc-ADAPT6 and 99mTc-DARPinG3, to see how well they can detect HER2-positive breast cancer using SPECT scans. Fifteen women with HER2-positive breast cancer will receive injections of each agent a few days apart, followed by …

This early study tested a new radioactive tracer called 99mTc-1-thio-D-glucose in 16 adults with Hodgkin or non-Hodgkin lymphoma. The tracer was injected once, and SPECT scans were taken over 24 hours to see where it went in the body. The goal was to check safety and whether the …

This study tested a new radioactive tracer called 99mTc-ZHER2:41071 in 30 women with breast cancer. The tracer is designed to attach to HER2 proteins on cancer cells, allowing doctors to see them on a SPECT scan. The goal was to see how the tracer spreads in the body, how safe it…

This completed phase 1 trial tested a radioactive imaging agent called [99mTc]Tc-DB8 in 10 people with prostate or breast cancer. The goal was to see how the agent spreads in the body and whether it can help detect tumors using SPECT scans. Researchers also checked for safety and…

This study tested whether a special heart scan (SPECT) can predict how well patients with ischemic cardiomyopathy will recover after heart surgery. 120 patients underwent imaging at rest and during stress to measure heart function and blood flow. The goal was to find patterns tha…

This study tested a new one-hour diagnostic algorithm using a protein called FABP to quickly confirm or rule out a type of heart attack called NSTEMI. It involved 20 male patients who arrived at the hospital within 4 hours of chest pain. The goal was to see if measuring FABP leve…

This completed study tested a new radioactive imaging agent called 99mTc-ADAPT6 to see if it can detect HER2 protein in breast cancer tumors using SPECT scans. Sixteen women with primary breast cancer received a single injection, followed by scans over six hours. The goal was to …

This study tested whether a special heart scan (SPECT) can predict which people with severe chronic heart failure will improve after getting a cardiac resynchronization therapy device. The scan uses a radioactive tracer to measure nerve activity in the heart. Researchers enrolled…

This early study tested a radioactive imaging agent called [99mTc]Tc(CO)3-(HE)3-Ec1 in 10 adults with solid tumors. The agent is designed to attach to EpCAM receptors on cancer cells, making them visible on SPECT scans. Researchers aimed to see where the agent goes in the body, m…

This study tested a special imaging tracer (99mTc-DARPinG3) to measure HER2 protein levels in breast cancer tumors using SPECT scans. Fifteen women with HER2-positive breast cancer received the tracer before and during chemotherapy plus targeted therapy. The goal was to see if th…

This study tested a radioactive sugar-like tracer called 99mTc-1-thio-D-glucose to see if it can make brain tumors visible on SPECT scans. Sixteen adults with primary or recurrent brain tumors received one injection, then had scans at several time points. Researchers measured how…

This completed phase 1 study tested a new radioactive imaging agent called 99mTc-RM26 in 10 people with prostate or breast cancer. The goal was to see how the agent spreads in the body and whether it can help spot tumors using SPECT scans. Researchers also checked for safety and …

This completed Phase 1 trial tested a new radioactive tracer called 99mTc-HE3-G3 to see if it can safely and accurately detect HER2 protein in breast cancer tumors using SPECT imaging. Thirty adults with primary breast cancer received one injection of the tracer, followed by scan…

This study tested a new imaging method that uses a radioactive tracer to detect HER2 protein in breast cancer tumors and nearby lymph nodes. 24 women with primary breast cancer received one injection followed by a scan. The goal was to see if the scan results matched standard tis…

This study tested a new imaging agent called 99mTc-ADAPT6 in 30 women with breast cancer that had spread to lymph nodes. The agent is designed to attach to HER2 proteins on cancer cells, allowing doctors to see them on a SPECT scan. The goal was to see if the scan results matched…

This study tested a new radioactive imaging agent that binds to the HER2 protein, which is important for guiding breast cancer treatment. Ten women with known HER2-positive or HER2-negative breast cancer received one injection of the agent, followed by several SPECT scans over 24…

This completed Phase 1 study tested a new radioactive imaging agent called [123I]I-DARPIN-Ec1 in 10 people with lung or ovarian cancer. The goal was to see how the agent spreads in the body and whether it can help spot tumors on SPECT scans. Researchers compared the new scan resu…

This completed Phase 1 study tested a new radioactive tracer called [99mTc]Tc-BQ0413 in 10 men with prostate cancer. The tracer was injected once, and SPECT scans were taken over 24 hours to see where it goes in the body and how safe it is. The goal is to develop a better imaging…

This early study tested a new radioactive imaging agent, called [123I] I-(HE)3-G3, to see if it can safely detect HER2 protein in breast cancer tumors using SPECT scans. Ten people with either HER2-positive or HER2-negative breast cancer received one injection and were scanned ov…

This study tested whether breathing in high-dose nitric oxide (NO) gas after heart surgery could prevent pneumonia. 74 patients who had heart surgery with a heart-lung machine were randomly assigned to receive either NO gas or a placebo (oxygen-air mixture) for 30 minutes twice a…

This study tested whether breathing high-dose nitric oxide (NO) gas for 30 minutes twice a day for 5 days after heart surgery could prevent hospital-acquired pneumonia. 160 adults who had elective heart surgery with a heart-lung machine took part. Half received NO, half received …

This study tested whether giving mannitol, a substance that reduces brain swelling, could prevent delirium in older adults hospitalized for a heart attack. Fifty patients aged 65 and older with high inflammation levels were included. The goal was to see if mannitol could lower th…

This study examined bleeding inside the heart muscle (intramyocardial hemorrhage) in 60 patients who had a severe type of heart attack called STEMI. Researchers compared two treatment strategies: giving clot-busting drugs followed by a procedure to open the artery, versus going s…

This completed study looked at 260 patients with ischemic cardiomyopathy (a weak heart due to blocked arteries) who had heart surgery. The goal was to develop a personalized approach to choose the best type of surgery and predict risks and outcomes. Researchers used imaging, bloo…

This study looked at 200 men and women who had surgery to repair a small ascending aortic aneurysm (5.0-5.5 cm). Researchers wanted to see if gender affects early and long-term outcomes like death, heart attack, or bleeding. The goal is to understand why women might have worse re…

This study looked at how well surgery works for people with an enlarged aorta (aneurysm) in the chest. Researchers compared outcomes in 50 patients who had surgery versus those who did not, tracking deaths and how fast the aorta grew over time. The goal was to better understand w…

This completed study looked at whether a simple blood test (liquid biopsy) can help track breast, ovarian, and endometrial cancers. Researchers analyzed circulating tumor cells in 150 women to see if these cells could predict the risk of cancer spreading or how well treatment wor…

This study looked at how two types of drug-coated heart stents (Orsiro and Resolute Integrity) heal inside the arteries of 50 people with stable heart disease. Researchers used a special camera to check the healing 4 months after the stents were placed. The goal was to see if one…

This study looked at 100 people with coronary artery disease who had a heart procedure through the wrist. Half got a short sheath and half got a long sheath. The goal was to see which one leads to fewer blockages in the radial artery. Researchers used ultrasound to check for bloc…

This study followed 380 people who had COVID-19 pneumonia for one year after they left the hospital. Researchers used heart ultrasounds, lab tests, and CT scans to check for heart problems. The goal was to understand how COVID-19 affects the heart over time.

This study examined how being obese (BMI over 30) affects hospital outcomes after coronary artery bypass grafting (CABG) in 500 patients with chronic ischemic heart disease. Researchers tracked death rates, neurological injury, kidney injury, breathing machine time, and need for …

This study tested a personalized breathing training that alternates low and high oxygen levels in 20 healthy adults aged 60-74. The goal was to see if it is safe and could create an 'organ-protective' state. The training was tailored using a brain oxygen monitor. This is a very e…