Supernus Pharmaceuticals, Inc.

This study tested an experimental drug called SAGE-547 for people with super-refractory status epilepticus, a life-threatening condition where seizures do not stop despite multiple medications. The goal was to see if adding SAGE-547 to standard care was safe and could help contro…

This study tested whether an experimental drug called SAGE-547 could help patients with a severe, life-threatening form of continuous seizures that does not respond to standard medications. The trial involved 132 patients who were already in intensive care and receiving strong an…

This study tested how well the approved ADHD medication Qelbree works for adults who have both ADHD and symptoms of depression or anxiety. 161 adults participated in this 14-week trial, which was conducted entirely remotely using a smartphone app for doctor visits and questionnai…

This early-stage study tested the safety and how the body processes SAGE-718, an oral liquid medication being developed for Huntington's disease. It involved a small group of healthy adults and a few patients with Huntington's disease. The main goal was to see if the drug was saf…

This study tested whether a 60-hour IV treatment for postpartum depression could be safely given at home instead of in a hospital. It involved 52 women and carefully monitored for safety issues and whether healthcare providers could follow all the required safety steps in a home …

This study tested whether an intravenous drug called SAGE-547 could quickly reduce severe depression in women suffering from postpartum depression. Twenty-one women within six months of giving birth were randomly assigned to receive either the drug or a placebo infusion. Research…

This study tested whether an experimental drug called SAGE-718 could improve thinking skills in people with early Huntington's disease. For 28 days, 69 participants either received the drug or a placebo (inactive substance) in a double-blind trial where neither they nor the resea…

This small, early study tested the safety and initial effects of an experimental injection called SAGE-547 for severe postpartum depression. Four adult women with severe depression after childbirth received the treatment. Researchers closely monitored their health and checked if …

This study tested the safety and how the body processes brexanolone, an intravenous medication, in teenage mothers with postpartum depression. It involved 28 adolescent female participants who were within 6 months of giving birth. The goal was to gather information to see if this…

This study tested the safety and side effects of an experimental drug called SAGE-718 in people with Parkinson's disease who have mild thinking and memory problems. Eighteen participants with early to moderate Parkinson's took the drug to see how well they tolerated it and whethe…

This completed Phase 3 trial tested whether a 60-hour intravenous infusion of an experimental drug, SAGE-547, could reduce depressive symptoms in women with moderate to severe postpartum depression. The study involved 108 women who were within six months of giving birth and compa…

This study tested the safety and side effects of an investigational drug called SAGE-718 in people with early memory problems or mild dementia due to Alzheimer's disease. It involved 26 participants and also looked at whether the drug had any effects on their thinking skills and …

This study tested whether an investigational drug called SAGE-718 could improve cognitive performance, specifically processing speed, in people with early-stage Alzheimer's disease or mild cognitive impairment. 174 participants were randomly assigned to receive either the drug or…

This study tested whether a 60-hour intravenous infusion of an experimental drug called SAGE-547 could reduce severe depressive symptoms in women with postpartum depression. It involved 138 women who were within 6 months of giving birth and had severe symptoms. The main goal was …

This study tested the safety and side effects of four different doses of an experimental drug called SPN-810. It involved 78 children, aged 6 to 12, who had both ADHD and persistent, serious conduct problems like property destruction or physical fights. The main goal was to see h…

This small, completed study tested whether a single intravenous (IV) infusion of a drug called brexanolone was safe and could reduce symptoms for adults with tinnitus. Ten participants received a 6-hour infusion, and researchers measured changes in how loud and annoying their tin…

This study tested whether an investigational drug called SAGE-718 could improve thinking skills like memory, attention, and problem-solving in people with Huntington's disease. It involved 189 participants with mild-to-moderate cognitive impairment who took either the drug or a p…

This study tested whether an investigational drug called SAGE-718 could improve cognitive performance, specifically thinking speed, in people with Parkinson's disease who have mild thinking problems. 86 participants were randomly assigned to receive either the drug or a placebo f…

This early-stage study tested an experimental drug called SAGE-718 in healthy volunteers. Researchers gave participants either the drug or a placebo, along with a single dose of ketamine, to see how it affected brain chemicals measured by MRI scans. The main goal was to check the…

This early-stage study tested an experimental drug called SAGE-718 in 40 healthy volunteers. Researchers gave participants either SAGE-718 or a placebo, then used a low dose of ketamine to temporarily alter brain activity and measure the drug's effects. The main goals were to che…

This study aimed to understand how an experimental drug called SAGE-904 affects brain activity. Researchers gave 22 healthy volunteers either SAGE-904 or a placebo, then measured their brain waves before and after receiving a low dose of ketamine. The goal was to see if SAGE-904 …

This early-stage study tested a new oral drug called SAGE-718 in healthy volunteers. Researchers gave participants SAGE-718 or a placebo along with ketamine to see how it affects brain wave patterns and to check if it's safe. The main goal was to gather information about the drug…