Could a pill boost brain function in Huntington's? new trial tests SAGE-718

NCT ID NCT05107128

Completed Symptom relief Sponsor: Supernus Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested an experimental drug called SAGE-718 to see if it could improve cognitive function (like attention and processing speed) in people with Huntington's disease. 189 participants took either the drug or a placebo daily for a period of time. The main goal was to measure changes in a symbol-digit matching test. The trial has completed, and results will show whether SAGE-718 offers any benefit for thinking skills in Huntington's.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SAGE-718 (oral capsules)
What this could lead to: If it works, this could point toward a treatment to help with thinking and memory problems in Huntington's disease.
What could go wrong: This is a Phase 2 trial, so results are still early. The drug may not improve cognition significantly, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Huntington disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HUNTINGTON'S DISEASE

Contacts and locations

Locations

Sage Investigational Site

Little Rock, Arkansas, 72205, United States
Sage Investigational Site

La Jolla, California, 92037, United States
Sage Investigational Site

Los Angeles, California, 90095, United States
Sage Investigational Site

Sacramento, California, 95817, United States
Sage Investigational Site

Englewood, Colorado, 80113, United States
Sage Investigational Site

Washington D.C., District of Columbia, 20007, United States
Sage Investigational Site

Boca Raton, Florida, 33431, United States
Sage Investigational Site

Boca Raton, Florida, 33486, United States
Sage Investigational Site

Tampa, Florida, 33612, United States
Sage Investigational Site

Honolulu, Hawaii, 96817, United States
Sage Investigational Site

Chicago, Illinois, 60611, United States
Sage Investigational Site

Chicago, Illinois, 60612, United States
Sage Investigational Site

Indianapolis, Indiana, 46202, United States
Sage Investigational Site

Iowa City, Iowa, 52242, United States
Sage Investigational Site

Kansas City, Kansas, 66160, United States
Sage Investigational Site

Baltimore, Maryland, 21287, United States
Sage Investigational Site

Boston, Massachusetts, 02129, United States
Sage Investigational Site

Boston, Massachusetts, 02215, United States
Sage Investigational Site

Farmington Hills, Michigan, 48334, United States
Sage Investigational Site

Buffalo, New York, 14221, United States
Sage Investigational Site

New York, New York, 10032, United States
Sage Investigational Site

Chapel Hill, North Carolina, 27599, United States
Sage Investigational Site

Durham, North Carolina, 27705, United States
Sage Investigational Site

Cincinnati, Ohio, 45219, United States
Sage Investigational Site

Toledo, Ohio, 43614, United States
Sage Investigational Site

Philadelphia, Pennsylvania, 19107, United States
Sage Investigational Site

Charleston, South Carolina, 29425, United States
Sage Investigational Site

Memphis, Tennessee, 38157, United States
Sage Investigational Site

Nashville, Tennessee, 37212, United States
Sage Investigational Site

Houston, Texas, 77030, United States
Sage Investigational Site

Richmond, Virginia, 23298, United States
Sage Investigational Site

Kirkland, Washington, 98034, United States
Sage Investigational Site

Spokane, Washington, 99202, United States
Sage Investigational Site

Madison, Wisconsin, 53792, United States
Sage Investigational Site

Westmead, New South Wales, 2145, Australia
Sage Investigational Site

Herston, Queensland, 4029, Australia
Sage Investigational Site

Bethlehem, Victoria, 3162, Australia
Sage Investigational Site

Nedlands, Western Australia, 6009, Australia
Sage Investigational Site

Halifax, Nova Scotia, B3S 1N2, Canada
Sage Investigational Site

North York, Ontario, M2K 1E1, Canada
Sage Investigational Site

Montreal, Quebec, H2X 0A9, Canada
Sage Investigational Site

Tooting, London, SW17 0QT, United Kingdom
Sage Investigational Site

Aberdeen, AB25 2ZA, United Kingdom
Sage Investigational Site

Birmingham, B15 2FG, United Kingdom
Sage Investigational Site

Cardiff, CF10 3AX, United Kingdom
Sage Investigational Site

Leeds, LS7 4SA, United Kingdom
Sage Investigational Site

Newcastle upon Tyne, NE6 4QD, United Kingdom
Sage Investigational Site

Plymouth, PL6 8BT, United Kingdom
Sage Investigational Site

Southampton, SO16 6YD, United Kingdom

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