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Could a pill boost brain function in Huntington's? new trial tests SAGE-718

NCT ID NCT05107128

Completed Symptom relief Sponsor: Supernus Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested an experimental drug called SAGE-718 to see if it could improve cognitive function (like attention and processing speed) in people with Huntington's disease. 189 participants took either the drug or a placebo daily for a period of time. The main goal was to measure changes in a symbol-digit matching test. The trial has completed, and results will show whether SAGE-718 offers any benefit for thinking skills in Huntington's.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

SAGE-718 (oral capsules)

What this could lead to

If it works, this could point toward a treatment to help with thinking and memory problems in Huntington's disease.

What could go wrong

This is a Phase 2 trial, so results are still early. The drug may not improve cognition significantly, and side effects are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Huntington disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HUNTINGTON'S DISEASE

Contacts and locations

Locations

  • Sage Investigational Site

    Little Rock, Arkansas, 72205, United States

  • Sage Investigational Site

    La Jolla, California, 92037, United States

  • Sage Investigational Site

    Los Angeles, California, 90095, United States

  • Sage Investigational Site

    Sacramento, California, 95817, United States

  • Sage Investigational Site

    Englewood, Colorado, 80113, United States

  • Sage Investigational Site

    Washington D.C., District of Columbia, 20007, United States

  • Sage Investigational Site

    Boca Raton, Florida, 33431, United States

  • Sage Investigational Site

    Boca Raton, Florida, 33486, United States

  • Sage Investigational Site

    Tampa, Florida, 33612, United States

  • Sage Investigational Site

    Honolulu, Hawaii, 96817, United States

  • Sage Investigational Site

    Chicago, Illinois, 60611, United States

  • Sage Investigational Site

    Chicago, Illinois, 60612, United States

  • Sage Investigational Site

    Indianapolis, Indiana, 46202, United States

  • Sage Investigational Site

    Iowa City, Iowa, 52242, United States

  • Sage Investigational Site

    Kansas City, Kansas, 66160, United States

  • Sage Investigational Site

    Baltimore, Maryland, 21287, United States

  • Sage Investigational Site

    Boston, Massachusetts, 02129, United States

  • Sage Investigational Site

    Boston, Massachusetts, 02215, United States

  • Sage Investigational Site

    Farmington Hills, Michigan, 48334, United States

  • Sage Investigational Site

    Buffalo, New York, 14221, United States

  • Sage Investigational Site

    New York, New York, 10032, United States

  • Sage Investigational Site

    Chapel Hill, North Carolina, 27599, United States

  • Sage Investigational Site

    Durham, North Carolina, 27705, United States

  • Sage Investigational Site

    Cincinnati, Ohio, 45219, United States

  • Sage Investigational Site

    Toledo, Ohio, 43614, United States

  • Sage Investigational Site

    Philadelphia, Pennsylvania, 19107, United States

  • Sage Investigational Site

    Charleston, South Carolina, 29425, United States

  • Sage Investigational Site

    Memphis, Tennessee, 38157, United States

  • Sage Investigational Site

    Nashville, Tennessee, 37212, United States

  • Sage Investigational Site

    Houston, Texas, 77030, United States

  • Sage Investigational Site

    Richmond, Virginia, 23298, United States

  • Sage Investigational Site

    Kirkland, Washington, 98034, United States

  • Sage Investigational Site

    Spokane, Washington, 99202, United States

  • Sage Investigational Site

    Madison, Wisconsin, 53792, United States

  • Sage Investigational Site

    Westmead, New South Wales, 2145, Australia

  • Sage Investigational Site

    Herston, Queensland, 4029, Australia

  • Sage Investigational Site

    Bethlehem, Victoria, 3162, Australia

  • Sage Investigational Site

    Nedlands, Western Australia, 6009, Australia

  • Sage Investigational Site

    Halifax, Nova Scotia, B3S 1N2, Canada

  • Sage Investigational Site

    North York, Ontario, M2K 1E1, Canada

  • Sage Investigational Site

    Montreal, Quebec, H2X 0A9, Canada

  • Sage Investigational Site

    Tooting, London, SW17 0QT, United Kingdom

  • Sage Investigational Site

    Aberdeen, AB25 2ZA, United Kingdom

  • Sage Investigational Site

    Birmingham, B15 2FG, United Kingdom

  • Sage Investigational Site

    Cardiff, CF10 3AX, United Kingdom

  • Sage Investigational Site

    Leeds, LS7 4SA, United Kingdom

  • Sage Investigational Site

    Newcastle upon Tyne, NE6 4QD, United Kingdom

  • Sage Investigational Site

    Plymouth, PL6 8BT, United Kingdom

  • Sage Investigational Site

    Southampton, SO16 6YD, United Kingdom