New Huntington's drug candidate SAGE-718 enters first human safety tests
NCT ID NCT03787758
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-stage trial tested the safety and tolerability of an experimental drug called SAGE-718 in 6 healthy adults and a small group of people with Huntington's disease. Researchers looked for side effects and measured how the drug moves through the body. The goal was to see if the drug is safe enough to study further, not to test if it works.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
SAGE-718
What this could lead to
If this early trial shows the drug is safe, it could pave the way for larger studies testing whether SAGE-718 can help control Huntington's disease symptoms.
What could go wrong
This is a very small, early-stage trial focused on safety, not effectiveness. The drug may not work for Huntington's or could have side effects. Results may not apply to all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Sage Investigational Site
Long Beach, California, 90806, United States
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Sage Investigational Site
Marlton, New Jersey, 08053, United States