HUNTINGTON DISEASE

This Phase 3 study tests whether the drug votoplam can slow the progression of Huntington's disease in people with early symptoms. About 770 adults aged 21-70 with confirmed Huntington's will receive either votoplam or a placebo. The main goal is to see if the drug helps maintain…

This early-stage trial tests whether implanting human neural stem cells into the brain is safe for people with Huntington's disease. About 21 adults aged 18-65 with a confirmed genetic diagnosis will receive the cells and be monitored for side effects. The goal is to see if the p…

This study tests a new gene therapy called SPK-10001 for people with Huntington's disease. It involves a one-time infusion into specific brain areas to see if it is safe and can help control symptoms. About 53 adults with early-stage Huntington's will take part. The goal is to sl…

This study tests an oral medication called SKY-0515 in 400 adults aged 25 and older with Huntington's disease. The goal is to see if the drug can lower harmful proteins and improve movement, thinking, and daily function. Participants are randomly assigned to receive either the dr…

This study aims to see if a blood test from the mother can accurately diagnose genetic disorders in the fetus, such as sickle cell disease or cystic fibrosis, as early as 9 weeks into pregnancy. The test uses fetal DNA found in the mother's blood, avoiding the miscarriage risk of…

This study tests a new radioactive tracer that may light up harmful protein clumps in the brains of people with Huntington's disease during a PET scan. Researchers will scan 27 adults (healthy volunteers and people with early-stage Huntington's) to see if the tracer works safely …

This study tests whether low-intensity focused ultrasound can safely improve motor symptoms in people with Huntington's disease. About 24 adults with genetically confirmed Huntington's will receive the ultrasound treatment. The goal is to find the best pulse frequency that reduce…

This study tests a smartphone app designed to help people with Huntington's or Parkinson's disease feel less anxious. The app works by training users to interpret everyday situations in a less threatening way. Researchers will enroll 136 participants to see if the app improves an…

This study tests whether a gentle brain stimulation technique called tDCS, used daily at home for 30 minutes, can help with behavioral and thinking problems in Huntington's disease. Sixteen adults with early to moderate Huntington's will try the device and answer questionnaires. …

This small pilot study is testing whether adding music therapy to usual care can reduce irritability and impulsivity in people with early-stage Huntington's disease. Fifteen participants will use a digital music therapy tool for three months. The goal is to find a non-drug way to…

This study tests whether a gentle brain stimulation device (tDCS) used at home is safe and helpful for people with early to moderate Huntington's disease. Ten participants will use the device daily for several weeks. The goal is to see if it can improve mood, thinking, and other …

This study is testing whether wearable devices like smartwatches can accurately track movement problems in people with Huntington's disease. About 100 participants, including healthy volunteers, will wear sensors and complete surveys and interviews at home. The goal is to find be…

This study looks at two thinking and memory tests—the Coding Test and the SAGE—to see if they can help screen and track Huntington's disease. Researchers will compare these tests with standard ones in 76 adults aged 30-65 who have a genetic diagnosis of Huntington's. The goal is …

This study looks at a protein called BDNF in the spinal fluid and blood of people with Huntington's disease. BDNF helps keep brain cells healthy, and it may be lower in people with Huntington's. Researchers will compare BDNF levels between 135 participants (people with Huntington…

This study looks at whether a test called the Hinting Task can pick up on social thinking problems in people with Huntington's disease. Social thinking helps us understand hints and read between the lines in conversations. Researchers will compare results from 52 people with Hunt…

This study looks at how Huntington disease affects social skills, like understanding others' feelings and intentions. Researchers will test a new tool called DMASC-MC in 40 adults with early Huntington disease and compare it to existing tests. The goal is to find better ways to i…

This study is looking at whether simple, non-invasive eye scans can help detect and track brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will use special cameras to take detailed pictures of the retina in 2,000 adults—both those with and without…

This study aims to collect health information from 600 adults with Huntington disease (or those who carry the gene but have no symptoms yet) over 24 months. Participants will answer online surveys from home, helping researchers understand how the disease progresses and what facto…

This study aims to understand specific genetic markers (called SNPs) in people who carry the Huntington disease gene. Researchers will collect a blood sample and medical history from 600 adults aged 25 to 60. No treatment is given; the goal is to learn more about the disease's ge…