HUNTINGTON DISEASE

This large, late-stage study is testing whether a new drug called votoplam can slow down the progression of Huntington's disease in people who have just started showing symptoms. About 770 participants will receive either the drug or a placebo for up to three years to see if it h…

This early-stage study is testing a one-time experimental therapy called SPK-10001 for Huntington's disease. Doctors will infuse the therapy directly into specific areas of the brain. The main goals are to see if the treatment is safe and if it can slow the progression of the dis…

This clinical trial is testing whether a new oral medication called SKY-0515 can reduce harmful proteins in the brain and improve symptoms for people with Huntington's Disease. The study will involve 120 adults with genetically confirmed Huntington's who will take either the drug…

This study is testing whether a new oral medication called SKY-0515 can slow the progression of Huntington's Disease by reducing harmful proteins in the brain. The trial will involve 400 adults aged 25+ with genetically confirmed Huntington's who are still fairly independent. Par…

This study is evaluating a new, non-invasive blood test to diagnose serious inherited genetic disorders in unborn babies. The test analyzes tiny bits of the baby's DNA found in the mother's blood, aiming to provide a safe and accurate diagnosis as early as 9 weeks into pregnancy.…

This study is testing whether a safe, non-invasive brain stimulation device can be used at home by people with Huntington's disease. The main goal is to see if this approach is practical and acceptable, and if it might help ease common symptoms like mood changes, thinking problem…

This small pilot study is testing whether adding music therapy to standard care can help reduce irritability and impulsivity in people with early-stage Huntington's disease. Fifteen patients will use a digital music therapy tool for three months while researchers track changes in…

This study is testing a phone app designed to help reduce anxiety in people with Huntington's or Parkinson's disease. The app uses daily exercises to help participants change unhelpful, negative thought patterns. Researchers will compare the app's effects on anxiety and quality o…

This small study is testing whether a daily, at-home brain stimulation treatment is safe and practical for people with Huntington's disease. Researchers want to see if this non-invasive therapy can help improve thinking skills and mood-related symptoms. Participants will use a de…

This study aims to test whether a social skills assessment called the Hinting Task works well for people with Huntington's disease. Researchers will compare how 52 Huntington's patients perform on this test compared to healthy volunteers. The goal is to better understand and meas…

This study aims to understand if two existing cognitive tests—the Coding Test and the Self-Administered Gerocognitive Examination (SAGE)—are useful for people with Huntington's disease. Researchers will enroll 76 participants with Huntington's disease for a single visit to comple…

This study aims to see if wearable devices can reliably measure walking problems and involuntary movements in people with Huntington's disease during their daily lives at home. Researchers will enroll 100 participants, including people with Huntington's and healthy volunteers, wh…

This study aims to test whether a new assessment tool can detect problems with social understanding in people with early Huntington's disease. Researchers will compare 20 people with Huntington's to 20 healthy volunteers using several tests that measure how well people understand…

This study is testing a new brain imaging tracer to see if it can measure the harmful mutant huntingtin protein that builds up in the brains of people with Huntington's disease. Researchers will use PET scans to compare 27 participants, including healthy volunteers and people at …

This study aims to collect genetic information from people with Huntington's Disease to better understand how specific gene variations are linked to the disease-causing mutation. Researchers will enroll 600 participants who will answer questions about their health and provide a s…

This study aims to better understand how Huntington's Disease progresses by collecting health information directly from patients online over two years. It will enroll 600 adults in the US who have been diagnosed with HD or carry the gene but don't yet have symptoms. Participants …

This study aims to understand Huntington's disease better by measuring specific proteins in spinal fluid and blood. Researchers will compare 90 people with Huntington's disease to 45 people without the disease, looking for biological markers that track with disease severity. The …

This study aims to see if detailed pictures of the back of the eye (the retina) can reveal early signs of brain diseases like Alzheimer's and Parkinson's. Researchers will use special, non-invasive camera scans on 2000 people, both with and without these conditions. The goal is t…