Brain stem cells implanted in first human trial for Huntington's

NCT ID NCT07451613

Recruiting now Disease control Sponsor: Leslie Thompson Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial tests whether implanting human neural stem cells into the brain is safe for people with Huntington's disease. Twenty-one adults with confirmed Huntington's will receive the stem cell therapy and be monitored for side effects over 12 weeks and up to a year. It is the first time this treatment is being studied in humans.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: neural stem cells (hNSC-01)
What this could lead to: If safe and effective, this could point toward a treatment that slows or controls Huntington's disease progression.
What could go wrong: This is the first human test of this stem cell therapy, so safety and effectiveness are unknown. The trial is small (21 people) and early-stage, so results may not apply broadly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Huntington disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HUNTINGTON DISEASE

Contacts and locations

Locations

University of California, Irvine
RECRUITING

Irvine, California, 92697, United States

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Other studies related to the condition(s) this trial covers.