New pill aims to tackle Huntington's at its source
NCT ID NCT07378644
First seen Jun 26, 2026 · Last updated Jul 01, 2026 · Updated 2 times
Summary
This clinical trial tests an oral drug called SKY-0515 in 400 adults with Huntington's disease. The goal is to see if it can lower harmful proteins linked to the disease and improve symptoms like movement and thinking. Participants take the drug or a placebo daily for 18 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
SKY-0515 (an oral small molecule drug)
What this could lead to
If successful, this could point toward a treatment that slows or improves Huntington's disease symptoms by lowering harmful proteins in the brain.
What could go wrong
This is an early-to-mid stage trial, so the drug may not work or could have side effects. The results may not apply to all people with Huntington's disease.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Buenos Aires British Hospital
RECRUITINGCABA, Buenos Aires, 1280AEB, Argentina
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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CETRAM (Centro de Trastornos del Movimiento)
RECRUITINGSantiago, Santiago Metropolitan, 9120500, Chile
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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CINME Centro de Investigaciones Metabólicas
RECRUITINGCABA, Buenos Aires, C1056 AB, Argentina
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-••••
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Fundación Scherbovsky
RECRUITINGMendoza, Mendoza Province, M5500, Argentina
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Instituto Argentino de Investigación Neurológica
RECRUITINGCABA, Buenos Aires, C1015ABR, Argentina
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-••••
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North York General Hospital
NOT_YET_RECRUITINGToronto, Ontario, M2K 1E1, Canada
Contact
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PSEG Centro de Pesquisa Clinica
RECRUITINGSão Paulo, São Paulo, 04038002, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Pineo Medical Ecosystem
RECRUITINGTbilisi, Georgia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Sanatorio Mater Dei
RECRUITINGCABA, Buenos Aires, C1425, Argentina
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Simon Khechinashvili University Hospital
RECRUITINGTbilisi, Georgia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact