New pill aims to tackle Huntington's at its source

NCT ID NCT07378644

Recruiting now Disease control Sponsor: Skyhawk Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 14, 2026 · Updated 5 times

Summary

This clinical trial tests an oral drug called SKY-0515 in 400 adults with Huntington's disease. The goal is to see if it can lower harmful proteins linked to the disease and improve symptoms like movement and thinking. Participants take the drug or a placebo daily for 18 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SKY-0515 (an oral small molecule drug)
What this could lead to: If successful, this could point toward a treatment that slows or improves Huntington's disease symptoms by lowering harmful proteins in the brain.
What could go wrong: This is an early-to-mid stage trial, so the drug may not work or could have side effects. The results may not apply to all people with Huntington's disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Huntington disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HUNTINGTON DISEASE

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Buenos Aires British Hospital
RECRUITING

CABA, Buenos Aires, 1280AEB, Argentina
CETRAM (Centro de Trastornos del Movimiento)
RECRUITING

Santiago, Santiago Metropolitan, 9120500, Chile

Contact Email: •••••@•••••
CINME Centro de Investigaciones Metabólicas
RECRUITING

CABA, Buenos Aires, C1056 AB, Argentina
Centro de Pesquisas Clínicas do Hospital das Clínicas da Universidade Federal de Minas Gerais - Filial EBSERH
NOT_YET_RECRUITING

Belo Horizonte, Minas Gerais, 30130-100, Brazil
Clinical Hospital FMUSP (Hospital das Clínicas da Universidade de São Paulo)
NOT_YET_RECRUITING

São Paulo, São Paulo, 205661, Brazil
Faculdade de Medicina de Ribeirão Preto - FMRP
NOT_YET_RECRUITING

Ribeirão Preto, São Paulo, 14049-900, Brazil
Fundación Scherbovsky
RECRUITING

Mendoza, Mendoza Province, M5500, Argentina
Hospital Angelina Caron
NOT_YET_RECRUITING

Campina Grande do Sul, Paraná, 83430-000, Brazil
Hospital Universitario Pedro Ernesto (HUPE)
NOT_YET_RECRUITING

Rio de Janeiro, Rio de Janiero, 20550, Brazil
Hospital Universitário Onofre Lopes (HUOL)
NOT_YET_RECRUITING

Natal, Rio Grande do Norte, 59010-056, Brazil
IADIN (Instituto Argentino de Investigación Neurológica)
NOT_YET_RECRUITING

Buenos Aires, Buenos Aires, B1888AAE, Argentina
Instituto Argentino de Investigación Neurológica
RECRUITING

CABA, Buenos Aires, C1015ABR, Argentina
Instituto de Neurologia de Curitiba
NOT_YET_RECRUITING

Curitiba, Paraná, 81210-310, Brazil
North York General Hospital
NOT_YET_RECRUITING

Toronto, Ontario, M2K 1E1, Canada
PSEG Centro de Pesquisa Clinica
RECRUITING

São Paulo, São Paulo, 04038002, Brazil
PUCPR - Centro de Pesquisa da Pontifícia Universidade Católica do Paraná
NOT_YET_RECRUITING

Curitiba, Paraná, 80215-901, Brazil
Pineo Medical Ecosystem
RECRUITING

Tbilisi, Georgia
Sanatorio Mater Dei
RECRUITING

CABA, Buenos Aires, C1425, Argentina
Simon Khechinashvili University Hospital
RECRUITING

Tbilisi, Georgia

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