HUNTINGTON DISEASE
Clinical trials for HUNTINGTON DISEASE explained in plain language.
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Hope for Huntington's: experimental drug targets root cause
Disease control OngoingThis phase 2 trial tests an experimental drug called tominersen in 301 people with early-stage Huntington's disease. The drug aims to lower levels of the harmful mutant protein that causes the disease. Researchers will compare tominersen against a placebo to see if it can slow do…
Matched conditions: HUNTINGTON DISEASE
Phase: PHASE2 • Sponsor: Hoffmann-La Roche • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Brain injection aims to slow Huntington's
Disease control OngoingThis early-stage study tests a gene therapy called AB-1001 in 5 adults with early Huntington's disease. The treatment is injected directly into the brain to potentially slow the disease. The main goal is to check safety, but researchers will also look at brain changes on MRI and …
Matched conditions: HUNTINGTON DISEASE
Phase: PHASE1, PHASE2 • Sponsor: AskBio France, SAS, a subsidiary of AskBio Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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New pill aims to tame Huntington's disease by targeting toxic proteins
Disease control OngoingThis study tests an oral drug called SKY-0515 in 120 adults with Huntington's disease. The goal is to see if it can lower harmful proteins in the blood, slow brain changes, and improve symptoms. Participants must be 25 or older with a confirmed genetic diagnosis and a certain lev…
Matched conditions: HUNTINGTON DISEASE
Phase: PHASE2, PHASE3 • Sponsor: Skyhawk Therapeutics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:28 UTC
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New Huntington's drug shows promise in early safety trial
Disease control OngoingThis early-stage study tests an experimental drug, ER2001, in 27 adults with early Huntington's disease. The main goal is to check if the drug is safe and how the body processes it. Participants receive either the drug or a placebo once a week for 6 weeks, with follow-up for 6 mo…
Matched conditions: HUNTINGTON DISEASE
Phase: PHASE1, PHASE2 • Sponsor: ExoRNA Bioscience • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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New hope for Huntington's: Long-Term drug trial underway
Disease control OngoingThis study looks at the long-term safety and effects of the drug votoplam in people with Huntington's disease. About 144 participants who finished a previous votoplam study will take part. The goal is to see how the drug affects Huntington's protein levels and brain changes over …
Matched conditions: HUNTINGTON DISEASE
Phase: PHASE2 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Huntington's drug shows promise for speech and gait issues
Symptom relief OngoingThis study tests whether deutetrabenazine can improve speech clarity and walking ability in people with Huntington disease. About 30 adults with early to moderate symptoms will take the drug and be evaluated using speech tests and motion capture technology. The goal is to see if …
Matched conditions: HUNTINGTON DISEASE
Phase: PHASE2, PHASE3 • Sponsor: Vanderbilt University Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC
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Can a One-Page guide spark better End-of-Life talks for dementia patients?
Knowledge-focused OngoingThis study tests a short guide called the 'Jumpstart Guide' to help doctors have better conversations with dementia patients and their families about healthcare goals. Over 1,800 patients and their caregivers are taking part. Researchers will compare whether those whose doctors u…
Matched conditions: HUNTINGTON DISEASE
Phase: NA • Sponsor: University of Washington • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
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New brain scans reveal hidden changes years before Huntington's symptoms appear
Knowledge-focused OngoingThis study looks at 40 people with early-stage Huntington's disease and healthy volunteers to see how well two types of brain scans can detect changes over 2 years. Participants get PET and MRI scans plus clinical exams at the start and after 2 years. The goal is to find better w…
Matched conditions: HUNTINGTON DISEASE
Phase: NA • Sponsor: Universitaire Ziekenhuizen KU Leuven • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC