New pill aims to tame Huntington's disease by targeting toxic proteins

NCT ID NCT06873334

Ongoing Disease control Sponsor: Skyhawk Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an oral drug called SKY-0515 in 120 adults with Huntington's disease. The goal is to see if it can lower harmful proteins in the blood, slow brain changes, and improve symptoms. Participants must be 25 or older with a confirmed genetic diagnosis and a certain level of independence.

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Conditions

The condition(s) this trial relates to.

choreatic disease Huntington disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HUNTINGTON DISEASE HUNTINGTONS DISEASE

Contacts and locations

Locations

Auckland City Hospital

Auckland, 1023, New Zealand
Calvary Health Care Bethlehem

Caulfield South, Victoria, 3162, Australia
Christchurch Neurology Trials Limited

Christchurch, 8011, New Zealand
Flinders Medical Centre

Adelaide, South Australia, 5042, Australia
Huntington's Disease Association

Auckland, 0604, New Zealand
John Hunter Hospital

New Lambton Heights, New South Wales, 2305, Australia
Launceston General Hospital

Launceston, Tasmania, 7250, Australia
The Perron Institute for Neurology and Translational Science (Perron Institute)

Nedlands, Western Australia, 6009, Australia
The Royal Melbourne Hospital

Parkville, Victoria, 3050, Australia
The University of Queensland

Herston, Queensland, 4006, Australia
Wellington Hospital

Wellington, 6021, New Zealand
Westmead Hospital

Westmead, New South Wales, 2145, Australia

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