HUNTINGTON DISEASE

This early study tested a new drug called ER2001, given by IV injection, in 10 adults with early Huntington's disease. The main goal was to check the safety of different doses and see how the drug moves through the body. Researchers also looked for early signs that the drug might…

This study tested whether metformin, a common diabetes medication, could help slow down the worsening of thinking and memory in people with Huntington's disease. For one year, 60 adult patients took either metformin or a placebo pill. Researchers measured changes in cognitive tes…

This study tested whether using immersive virtual reality (VR) or computer-based brain training games could help slow down memory and thinking problems in people with Parkinson's or Huntington's disease. It compared these high-tech approaches to a more traditional music therapy p…

This study tested an investigational drug called PTC518 in people with Huntington's disease to see if it was safe and if it could lower the harmful protein linked to the disease. 159 participants received either the drug or a placebo for up to a year. The main goals were to check…

This early-stage study tested the safety and how the body processes SAGE-718, an oral liquid medication being developed for Huntington's disease. It involved a small group of healthy adults and a few patients with Huntington's disease. The main goal was to see if the drug was saf…

This study tested whether a stem cell therapy called Cellavita HD could slow the progression of Huntington's disease, a severe genetic brain disorder. Forty-nine patients received either a low dose, a high dose, or a placebo via three monthly intravenous infusions. Researchers me…

This study tested whether an experimental drug called SAGE-718 could improve thinking skills in people with early Huntington's disease. For 28 days, 69 participants either received the drug or a placebo (inactive substance) in a double-blind trial where neither they nor the resea…

This study aimed to see if regular dance practice could help people with Huntington's Disease. Researchers enrolled 53 participants, including patients and their caregivers, for 8 months of weekly dance workshops. They measured changes in movement control, self-awareness, brain s…

This study tested whether group drumming classes could help people with Parkinson's or Huntington's disease. Eighteen participants attended drum lessons twice a week for 12 weeks. Researchers measured changes in movement, mood, and overall well-being to see if the music therapy p…

This study surveyed Huntington's disease patients, family members, and care partners to understand their feelings and attitudes about clinical trials. Researchers wanted to learn how to better communicate about research studies and make participation easier. The goal is to use th…

This study aimed to understand how brain energy levels change at different stages of Huntington's disease. Researchers used specialized MRI scans to measure energy-related chemicals in the brains of 50 patients. The goal was to see if changes in brain energy correlate with diseas…

This small study aimed to see if a potential treatment could improve how the brain uses energy in people with early Huntington's disease. Researchers used a special brain scan to measure energy levels before, during, and after a visual test. The goal was to gather information to …

This study investigated whether caffeine consumption affects how Huntington's disease progresses in people who carry the gene but don't yet show clear symptoms. Researchers followed 77 adults with the Huntington's gene mutation, measuring brain changes, movement, thinking skills,…