HUNTINGTON DISEASE

This study tested a drug called SAGE-718 in 69 people with early Huntington's disease to see if it could improve thinking and daily functioning. Participants took the drug or a placebo for 28 days. The main goal was to measure changes in cognitive abilities like memory and proble…

This study tested a stem cell treatment called Cellavita HD in 49 adults with Huntington's disease. Participants received one of two doses of the therapy or a placebo, and researchers measured changes in motor skills over time. The goal was to see if Cellavita HD could slow the w…

This study tested whether metformin, a common diabetes medicine, could help slow down thinking and memory problems in people with Huntington's disease. 60 adults with early Huntington's took either metformin or a placebo pill every day for a year. Researchers measured changes in …

This study tested a new drug called PTC518 in 159 people with Huntington's disease. The main goal was to see if the drug is safe and if it can lower the level of a harmful protein (huntingtin) in the blood. Researchers also looked at brain scans and symptom changes over 12 months…

This early study tested a new drug called ER2001 in 10 adults with early Huntington's disease. The main goal was to check if the drug is safe and how the body processes it. Participants received increasing doses over 14 weeks. Researchers also looked for early signs that the drug…

This study looked at whether taking weekly dance classes for 8 months can help people with Huntington's disease and their caregivers. Researchers tested movement, emotion, and brain changes in 18 patients and their partners. The goal was to see if dance improves how patients cont…

This study looked at whether group drum classes could help people with Parkinson's or Huntington's disease feel better and move easier. Eighteen adults aged 18-89 took drum lessons twice a week for 12 weeks. Researchers checked their hand movement, mood, and overall well-being be…

This study tested whether cognitive rehabilitation using immersive virtual reality or computer-based brain games could improve thinking skills in people with mild cognitive impairment from Parkinson's or Huntington's disease. 64 participants were randomly assigned to one of three…

This early-stage study tested the safety and tolerability of an experimental drug called SAGE-718 in 6 people: healthy adults and patients with Huntington's disease. The main goal was to check for side effects and how the drug moves through the body. It was a Phase 1 trial, meani…

This completed study surveyed 131 people affected by Huntington's disease (HD) to learn about their feelings, attitudes, and beliefs toward clinical research. Participants included people with HD or those at risk, aged 18 and older, living in the United States. The goal was to he…

This study tested whether a treatment could improve brain energy use in people with early Huntington disease. Ten participants had special MRI scans to measure brain metabolism. The goal was to see if the treatment could help brain cells work better and slow the disease.

This study looked at how brain energy levels change as Huntington disease progresses. Researchers used a special MRI technique to measure energy-related chemicals in the brains of 50 adults with Huntington disease. The goal was to understand the disease better, not to test a trea…

This study looked at whether drinking caffeine is linked to how Huntington's disease progresses in people who have the gene but do not yet show symptoms. 77 adults with early-stage Huntington's were observed, and researchers measured changes in brain volume and thinking skills. T…