Could a common diabetes drug protect the brain in Huntington's?
NCT ID NCT04826692
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether metformin, a widely used diabetes drug, can slow the loss of thinking skills in people with Huntington's disease. Sixty adults took either metformin or a placebo for one year. Researchers measured changes in memory, attention, and other cognitive functions using standard tests.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
metformin
What this could lead to
If it works, metformin could offer a safe, affordable way to slow cognitive decline in Huntington's disease.
What could go wrong
This is a small, early-phase trial. Metformin is not a cure, and it may not improve thinking or memory. Results may not apply to all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Complejo Hospitalario de Albacete
Albacete, Castille-La Mancha, 02006, Spain
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Hospital General Universitario Dr. Balmis
Alicante, Alicante, 03010, Spain
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Hospital General Universitario de Elche
Elche, Alicante, 03203, Spain
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Hospital Universitari Son Espases
Palma de Mallorca, Balearic Islands, 07120, Spain
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Hospital Universitario Burgos
Burgos, Castille and León, 09006, Spain
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Hospital Universitario Central de Asturias
Oviedo, Principality of Asturias, 33011, Spain
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Hospital Universitario Mare de Déu de la Mercé
Barcelona, Barcelona, 08035, Spain
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Hospital Universitario Ramón y Cajal
Madrid, Madrid, 28034, Spain
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Hospital Universitario y Politécnico La Fe
Valencia, València, 46026, Spain