Could a common diabetes drug protect the brain in Huntington's?
NCT ID NCT04826692
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether metformin, a widely used diabetes drug, can slow the loss of thinking skills in people with Huntington's disease. Sixty adults took either metformin or a placebo for one year. Researchers measured changes in memory, attention, and other cognitive functions using standard tests.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- metformin
- What this could lead to
- If it works, metformin could offer a safe, affordable way to slow cognitive decline in Huntington's disease.
- What could go wrong
- This is a small, early-phase trial. Metformin is not a cure, and it may not improve thinking or memory. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Complejo Hospitalario de Albacete
Albacete, Castille-La Mancha, 02006, Spain
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Hospital General Universitario Dr. Balmis
Alicante, Alicante, 03010, Spain
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Hospital General Universitario de Elche
Elche, Alicante, 03203, Spain
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Hospital Universitari Son Espases
Palma de Mallorca, Balearic Islands, 07120, Spain
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Hospital Universitario Burgos
Burgos, Castille and León, 09006, Spain
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Hospital Universitario Central de Asturias
Oviedo, Principality of Asturias, 33011, Spain
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Hospital Universitario Mare de Déu de la Mercé
Barcelona, Barcelona, 08035, Spain
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Hospital Universitario Ramón y Cajal
Madrid, Madrid, 28034, Spain
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Hospital Universitario y Politécnico La Fe
Valencia, València, 46026, Spain
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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