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New PET tracer aims to spot Huntington's protein clumps in living brains

NCT ID NCT06634628

Recruiting now Diagnosis Sponsor: CHDI Foundation, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage study tests a new radioactive tracer called [11C]CHDI-00491009 to see if it can safely and accurately detect harmful protein clumps (mutant huntingtin) in the brains of people with Huntington's disease. The study involves 27 participants, including healthy volunteers and people at different stages of Huntington's. If the tracer works, it could become a tool to measure disease progression and help develop future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
[11C]CHDI-00491009 (a radioactive tracer for PET scans)
What this could lead to
If successful, this tracer could allow doctors to see Huntington's disease progression in the brain, helping to develop and test new treatments.
What could go wrong
This is a very early, small study (27 people) focused on imaging, not treatment. The tracer may not reliably detect the protein clumps, and results may not apply to broader populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Huntington disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HD HUNTINGTON DISEASE HUNTINGTON'S HUNTINGTON'S DISEASE IMAGING MHTT PET TRACER POSITRON EMISSION TOMOGRAPHY RADIOLIGAND

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Universitaire Ziekenhuizen Leuven/ UZ Leuven/ UZL

    RECRUITING

    Leuven, 3000, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Email: •••••@•••••

    Contact

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