Memorial Sloan Kettering Cancer Center

This early-phase study tests a new treatment called ADCLEC.syn1 CAR T cells for adults with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The main goal is to find a safe dose and check for side effects. About 40 participants will receive th…

This study is for people with a specific type of oral tongue cancer who have had surgery. It tests whether giving radiation only to the neck lymph nodes (instead of the mouth) can reduce severe mouth sores and other side effects. Researchers will also track if the cancer returns …

This study tests whether pembrolizumab, a drug that helps the immune system attack cancer, can shrink or control ultra-rare sarcomas. About 32 adults with specific rare sarcoma types will receive the drug. The goal is to see if it works with mild side effects.

This study is testing whether a single, high-dose session of MRI-guided radiation can stop colorectal cancer that has spread to the liver from growing. About 32 adults with up to 3 small liver tumors will receive this treatment. Researchers will track how well it controls the tum…

This early-phase trial is testing whether combining two drugs, epcoritamab and ibrutinib, is safe for people with central nervous system (CNS) lymphoma that has come back or not responded to treatment. About 26 adults with this rare brain cancer will take part. The main goal is t…

This early-phase study tests a combination of two drugs, avutometinib and defactinib, in children and young adults (ages 3 to 30) with solid tumors that have returned or not responded to treatment. The main goal is to find a safe dose with manageable side effects. The drugs targe…

This study tests whether giving emapalumab early, before standard treatments, can improve blood cell recovery in children newly diagnosed with severe aplastic anemia. About 35 children will receive the drug and be monitored for 6 weeks. The goal is to see if this approach makes s…

This study tests a new treatment for older adults (65 and up) with diffuse large B-cell lymphoma (DLBCL) or similar lymphomas. The treatment combines the drugs glofitamab, polatuzumab, and obinutuzumab with a milder version of standard chemotherapy. The goal is to see if this app…

This study tests whether adding the drug pembrolizumab to standard chemotherapy (GVD) can help people with Hodgkin lymphoma that has returned or not responded to initial treatment. About 257 participants will receive the combination, and those who respond well may go on to a stem…

This study is testing a new drug called 2141-V11 for safety in people with a type of bladder cancer that hasn't improved with standard treatment. The drug is given directly into the bladder through a thin tube (catheter). About 55 people will take part to find the safest dose and…

This early-phase trial tests a new type of CAR T cell therapy for people with acute lymphoblastic leukemia (ALL) that has come back or not responded to standard treatments. The therapy uses a patient's own immune cells, modified in a lab to better target and kill cancer cells by …

This study tests whether combining bexarotene (a vitamin A-like drug) with ultra-low dose total skin electron beam radiation is safe for people with a type of skin lymphoma called mycosis fungoides. About 20 adults with stage IB or higher disease will receive both treatments at t…

This study is testing a new approach for people with certain head and neck cancers. Instead of the usual high-dose radiation, participants will receive lower-dose radiation and chemotherapy, followed by surgery to remove any remaining cancer in the neck. The goal is to see if thi…

This study tests whether adding the immunotherapy drug pembrolizumab, with or without the targeted drug olaparib, to standard radiation therapy is safe and works better than radiation alone for people with metastatic breast cancer. About 34 adults with triple-negative or hormone-…

This study tests whether combining the drug BMS986365 with hormone therapy (degarelix) before standard prostate removal surgery can safely eliminate or shrink high-risk prostate cancer. About 30 adults with localized high-risk prostate cancer will receive the combination for a sh…

This study looks at whether combining special PET and MRI scans with blood tests can detect pancreatic cancer early in people who have pancreatic cysts that are considered high-risk. The goal is to find cancer without needing surgery to remove the cyst. About 25 adults with high-…

This study tests a special anxiety treatment program designed for Latino older adults (65+) with cancer and their caregivers. The goal is to see if the program is practical and helpful in reducing anxiety. About 60 participants will take part to measure how many complete the prog…

This study tests a program called ICCAN that provides extra support to cancer patients getting chemotherapy or radiation. Researchers want to see if it helps patients finish their treatment and improves their quality of life, compared to standard hospital services. About 347 adul…

This study tests a precise radiation treatment (stereotactic radiosurgery) to relieve long-lasting pain in the chest or belly wall. About 18 adults whose pain hasn't been helped by standard treatments will receive a single dose of radiation to the nerve causing the pain. The goal…

This study tests whether giving the drug pembrolizumab after standard radiation therapy is safe for people with advanced adrenocortical carcinoma (a rare adrenal cancer). The trial will enroll 12 participants and focus on side effects. The goal is to find a treatment that control…

This study tests whether herbal plasters placed on the skin can help manage localized pain in cancer patients and survivors who are already taking opioids. Researchers want to see if the plasters are practical and effective. About 150 adults with cancer will use the plasters for …

This early-phase study is testing a new imaging agent called [68Ga]-pentixafor to see how well it shows up on PET/CT scans in people with certain blood cancers and tissue disorders. About 30 participants with conditions like multiple myeloma, non-Hodgkin lymphoma, or histiocytic …

This study aims to find out which small thyroid cancers are likely to grow and cause problems. Researchers will follow 750 people with small thyroid tumors and track their genetic and clinical features over time. The goal is to better predict disease progression so that patients …

This study is testing whether daily voice recordings made on a smartphone can help doctors spot early signs of a brain-related side effect called ICANS in people receiving CAR T-cell therapy for lymphoma or multiple myeloma. About 20 participants will record their voice twice a d…

This study looks at how a plant-based diet or supplements (omega-3, curcumin, or probiotics) change butyrate levels in stool after 2 weeks. Butyrate is a substance made by gut bacteria that may affect health. The study includes 200 adults with smoldering multiple myeloma or MGUS,…

This study looks at how men aged 45–70 with BRCA1/2 gene mutations respond to additional genetic risk testing for prostate cancer. Researchers want to understand if this extra information changes their screening choices and how it affects their emotions. The goal is to improve de…

This study is creating and improving educational materials about genetic testing for people with breast, ovarian, prostate, pancreatic, or colorectal cancer. Researchers will interview 445 patients from diverse cultural and language backgrounds to get their feedback. The goal is …

This study aims to develop and test a new MRI technique that may help doctors tell the difference between actual tumor growth and changes caused by radiation treatment in people with brain metastases. About 119 participants, including healthy volunteers and patients with untreate…

This study follows 475 women with breast cancer or lymphoma to understand how their treatments impact sexual function, fertility, and family-building decisions. Participants complete questionnaires and may optionally provide blood samples to measure ovarian health. The goal is to…

This study creates a registry for up to 500 people with Erdheim-Chester disease and other histiocytoses. Researchers will collect medical information and patient experiences to learn how these diseases progress and respond to treatments. Some participants may also be asked to com…

This study tests whether giving a fluorescent dye (fluorescein) before surgery helps surgeons see and remove all extramammary Paget's disease cells during vulvectomy. About 27 adults with noninvasive or microinvasive disease will receive the dye intravenously. Researchers will ch…