Memorial Sloan Kettering Cancer Center

This study tests whether combining two drugs, epacadostat and pembrolizumab, can shrink tumors in people with advanced sarcoma that has spread. About 30 adults who have already tried at least one prior treatment will receive the combination. The main goal is to see how many patie…

This study is for men with very high-risk or early-spread prostate cancer. It combines hormone-lowering injections, study drugs (abiraterone, prednisone, apalutamide), surgery, and possibly radiation to shrink the cancer as much as possible before surgery. The goal is to lower PS…

This study looks at whether aerobic exercise can lower ctDNA levels in the blood, which may help prevent cancer from returning. About 33 people who have been treated for breast, prostate, or colorectal cancer and are at high risk of relapse will try different amounts of weekly ex…

This study tests whether a pancreatic enzyme replacement called pancrelipase can help maintain or improve body weight in people with metastatic pancreatic cancer. About 17 participants will receive either the enzyme or a placebo, and researchers will measure changes in body mass …

This study tests a new way to calculate the dose of the chemotherapy drug melphalan for people with lymphoma who are about to have a stem cell transplant. Instead of using a standard dose based on height and weight, researchers use a model that considers how previous patients pro…

This study looks at whether giving cancer patients extra food help—like vouchers, grocery delivery, or a hospital food pantry—can help them finish their cancer treatment. About 606 patients who have trouble getting enough food will be randomly assigned to one of three food progra…

This study tests whether combining two drugs, lenvatinib and pembrolizumab, can safely shrink tumors in people with advanced soft tissue sarcoma that cannot be removed by surgery. About 52 adults with specific sarcoma types will receive the treatment. The goal is to see how well …

This study tests whether adding the drug durvalumab to targeted radiation (SBRT) helps keep early-stage non-small cell lung cancer from returning. It includes 13 people with stage I to IIIA disease. The main goal is to see if the combination improves how long people live without …

This study tests whether radiation therapy guided by a new imaging device (RCM/OCT) can effectively treat basal cell carcinoma, a common skin cancer. About 38 adults with early-stage tumors will receive this targeted radiation. Researchers will check if the cancer is gone after t…

This study tests whether adding the drug durvalumab to standard radiation therapy can help control locally advanced pancreatic cancer. About 18 people who have already received chemotherapy will receive the combination. The goal is to see if the treatment is safe and can shrink t…

This early-phase study tests whether a personalized cancer vaccine, made from a patient's own tumor, combined with an immunotherapy drug (atezolizumab) and chemotherapy is safe after pancreatic cancer surgery. About 29 adults with resectable pancreatic cancer will receive the vac…

This study tests whether giving radiation therapy before standard CAR T-cell treatment is safe and practical for people with B-cell lymphoma that has come back or not responded to prior treatments. About 20 participants will receive a split course of radiation to all active disea…

This study tests whether combining two immunotherapy drugs, durvalumab and tremelimumab, can shrink tumors in people with germ cell cancers that have come back or not responded to standard treatment. About 30 adults with measurable disease are participating. The main goal is to s…

This early-phase study tests whether romosozumab, a drug used for osteoporosis, can safely improve bone health in postmenopausal women who also have multiple myeloma. Ten participants receive the drug to see how it affects bone formation and breakdown. The goal is to manage bone …

This study tests a treatment using a patient's own immune cells (T cells) that are modified in a lab to attack cancer cells with a protein called mesothelin. It is for people with malignant pleural disease, including mesothelioma and cancers that have spread to the chest lining. …

This study tests a new way of giving radiation to men with intermediate-risk prostate cancer. Instead of many small doses over weeks, it uses a few very high doses (ultra-hypofractionated) guided by MRI to target the main tumor. The goal is to see if this approach is safe and fea…

This study tests whether giving a lower dose of radiation to a smaller area after surgery for soft tissue sarcoma works just as well as the standard approach to keep the cancer from coming back. The goal is to see if this gentler method causes fewer long-term side effects. About …

This study tests whether giving immunotherapy drugs (nivolumab alone or with ipilimumab) before bladder cancer surgery is safe and does not delay the operation. The goal is to shrink the tumor, making surgery more successful. About 52 people with muscle-invasive bladder cancer wh…

This early-stage study tests the safety of combining an experimental drug (GDC-0084) with radiation therapy for people whose cancer has spread to the brain or its lining and who have a specific genetic change (PIK3CA mutation). The goal is to find the best dose that causes few si…

This pilot study tests meclofenamate, a drug previously used for pain, in 30 adults with brain metastases that have returned or worsened. The goal is to see if the drug can control tumor growth and whether a larger trial is feasible. Participants take the drug and are monitored w…

This early-phase trial tests the safety of specially engineered immune cells (armored CAR T-cells) in people with certain blood cancers that have not responded to standard treatments. The cells are made from the patient's own blood and designed to better target and attack cancer …

This study tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy (gemcitabine and cisplatin) works better for advanced bladder cancer that has spread. About 32 adults with inoperable or metastatic disease will receive the drugs in two different orders …

This early study tests whether a laser inserted through the skin can safely destroy small thyroid cancers without surgery. Ten adults with papillary thyroid microcarcinoma (tumors 13 mm or smaller) will receive the laser treatment, then have the treated area removed six months la…

This study tests a drug called ado-trastuzumab emtansine (T-DM1) in adults with advanced solid tumors that have an abnormal HER2 gene. The drug aims to shrink or control the cancer by targeting HER2. About 131 people with lung, bladder, or other HER2-driven cancers will take part…

This study adds two chemotherapy drugs, irinotecan and temozolomide, to the standard treatment for people aged 1 to 40 with newly diagnosed Ewing sarcoma. The goal is to see if this stronger combination can improve event-free survival by preventing the cancer from coming back or …

This study tests a new drug called ERAS-601 in 12 adults with advanced chordoma that is getting worse. The goal is to see if the drug is safe and can shrink tumors or stop them from growing for at least 6 months. Participants take the drug alone, without other treatments.

This study tests whether giving a personalized dose of a drug called r-ATG before a stem cell transplant helps the immune system recover more quickly and reduces serious side effects. It includes children and adults with acute leukemia or myelodysplastic syndrome (MDS) who are re…

This study tests the drug amivantamab in people with a specific type of stomach or esophagus cancer that has certain gene changes (EGFR or MET). The goal is to see if the drug can shrink tumors and is safe. About 25 adults who have already tried at least one other treatment will …

This study tests a special camera that takes detailed pictures of skin spots to find cancer early, possibly avoiding the need for a biopsy. About 1,889 people with skin lesions or healthy skin will have their spots imaged and compared to standard biopsies. The goal is to make ski…

This study tests whether a plant-based diet is practical for overweight people with early blood conditions called MGUS or smoldering multiple myeloma. Researchers will see if participants can stick to the diet and lose weight, and whether it helps prevent progression to multiple …

This study looks at two common surgeries for cancer that has spread to the thigh bone, to see which one helps patients function better and have a better quality of life. About 73 people with weakened thigh bones from cancer took part. Researchers measured pain, mobility, and dail…

This study tests a program that helps cancer patients and their caregivers manage difficult emotions and communicate better about the illness. It includes a version tailored for Latinx participants. The goal is to reduce distress, improve quality of life, and help families discus…

This study trains home-care nurses to deliver a short, meaning-focused therapy to people with cancer who are homebound. The goal is to ease emotional distress and improve quality of life. About 81 patients and their nurses are taking part through a visiting nurse service.

This pilot study explores whether a non-invasive brain stimulation technique called tDCS, combined with memory exercises, is practical and well-tolerated by breast cancer survivors who have memory problems after chemotherapy. The study involves 18 survivors aged 40-65 who have co…

This study uses three advanced MRI techniques to see if they can predict how well head and neck cancer patients will respond to surgery or chemo-radiation. About 272 adults with head or neck cancer will get these scans before and early during treatment. The goal is to find marker…

This study looks at how radiation therapy for head and neck cancer might affect thinking skills like memory and concentration. Researchers will ask 54 newly diagnosed patients to complete thinking tests and questionnaires three times over one year. The goal is to better understan…

This study looks at how regular exercise might change the biology of breast tumors in women with early-stage breast cancer. Researchers will compare tumors from women who exercise regularly with those who do not, using DNA and RNA analysis. The goal is to learn more about exercis…

This study asks 3000 people who had skin cancer surgery to fill out a one-time online survey about how they feel about their appearance, scars, and quality of life. The goal is to learn what matters most to patients after surgery. No new treatments or medications are being tested…

This study collects leftover tissue, blood, and other body fluids from 6,000 people with benign or malignant tumors of the soft tissue, gastrointestinal tract, or abdomen. Researchers will use these samples to study the causes, prevention, diagnosis, and treatment of these cancer…

This study uses a radioactive antibody (124I-Hu3F8) and PET/CT scans to see how the antibody moves through the body and reaches tumors. Seven people with melanoma, neuroblastoma, or sarcoma will receive one injection and have multiple scans over several days. The goal is to under…

This pilot study tested whether a prehabilitation program—a set of exercises and health support before surgery—is practical and helpful for 22 women with advanced ovarian cancer. Participants received the program while undergoing chemotherapy to prepare for tumor-removal surgery.…

This study uses MRI scans to understand how prostate cancer changes after radiation treatment. Researchers want to see if MRI can help doctors manage treatment better and sooner. About 120 men with prostate cancer who are getting radiation will have MRI scans before and after tre…

This study looks at how doctors communicate with people who have glioblastoma, a serious brain cancer, and their caregivers. Researchers want to understand how information about the cancer, test results, and treatment choices is shared. The goal is to find ways to improve these c…

This study looks at whether people with Lynch Syndrome, a condition that raises the risk for several cancers, follow recommended cancer screening after genetic counseling. Researchers will track up to 1,530 participants to see who gets screened and what factors help or hinder tha…

This study looks at whether combining PET/MRI scans with blood and tissue tests can create a detailed profile of high-grade serous ovarian cancer. Researchers will use computers to analyze these combined results to better predict how tumors respond to treatment. The goal is to im…