Icahn School Of Medicine At Mount Sinai

This early-phase trial tested a combination of four therapies to see if they could safely boost the immune system to fight cancer. 17 adults with non-Hodgkin's lymphoma, metastatic breast cancer, or head & neck cancer received low-dose radiation and two immune-boosting drugs inje…

This study tested a special monitoring program to help teenagers who had a liver transplant take their anti-rejection medicine on time. The goal was to reduce the chance of organ rejection. The study included 148 teens who were already having trouble sticking to their medication.…

This study tested a drug called bimekizumab in 60 adults with moderate-to-severe plaque psoriasis who had not improved with other similar treatments. The drug works by blocking certain inflammatory substances in the body to reduce skin redness, scaling, and thickness. The main go…

This study tested whether adding an experimental drug (either a CCR2/5-inhibitor or an anti-IL-8) to the immunotherapy nivolumab before and after surgery could help shrink tumors and improve long-term survival in people with non-small cell lung cancer or liver cancer. 48 adults w…

This study tested whether ertugliflozin, a diabetes drug, can reduce excess fluid in the skin and tissues of people with heart failure without lowering blood volume. 28 adults with heart failure and reduced pumping ability took the drug or a placebo in a crossover design. The goa…

This study tested a new brain-training method to help people with heroin addiction lower their cravings. Participants watched drug-related videos while getting real-time feedback on their brain activity, learning to match the brain patterns of people further along in recovery. Th…

This study looked at whether changing antipsychotic medications can better control schizophrenia symptoms in people who are already on treatment but still have symptoms or side effects. About 219 adults with schizophrenia or schizoaffective disorder took part. Researchers tracked…

This study tested whether nintedanib, a drug used for other lung diseases, can slow down lung damage in people who had severe COVID-19. It included 103 adults who still had lung problems more than 30 days after their COVID diagnosis. The main goal was to see if the drug helped ma…

This study tested a new way to offer HIV prevention medication (PrEP) to people at high risk right in the emergency department. 26 adults who were HIV-negative and medically stable took part. The goal was to see if starting PrEP in the ER helps them follow up with a doctor within…

This study tested two types of pain-relief injections (liposomal bupivacaine vs. standard bupivacaine) given during open fibroid surgery. 140 women participated to see which method reduced the need for opioid painkillers after the operation. The goal was to improve pain control a…

This study tested a device called the Sana Pain Reliever for people with long-term nerve pain. 75 adults used the device at home for 8 to 14 weeks. Researchers measured changes in pain symptoms using a standard pain scale. The goal was to see if the device could help reduce pain …

This study tested a shorter radiation treatment schedule for head and neck cancer in people aged 70 and older. Instead of daily visits for 6-7 weeks, the goal was to reduce side effects and help patients complete treatment. The study enrolled 37 participants and looked at whether…

This study tested whether music therapy singing sessions can improve memory, language, and quality of life in 100 people with Alzheimer's disease or mild cognitive impairment. Over 12 months, participants met with a licensed music therapist and were assigned to either singing ses…

This study tested whether a special light treatment could improve thinking, sleep, and metabolism in 25 people with mild cognitive impairment or mild Alzheimer's disease who also had sleep problems. Participants lived at home and were not blind or on insulin for diabetes. The res…

This study tested whether a special light therapy, used for 6 months, could improve sleep, mood, thinking, and daily behavior in 100 people with Alzheimer's disease or mild cognitive impairment. Participants either received the active light treatment or a placebo light. The goal …

This study looked at whether different lengths of light exposure can improve sleep, mood, and agitation in people with Alzheimer's disease. 135 participants were randomly assigned to receive 2 hours, 4 hours, or all-day morning light. The goal was to see which light schedule work…

This study looked at whether live music experiences can help people with depression feel better. Researchers worked with 84 participants aged 8 to 70 who had depression or were at risk for it. They measured changes in mood, resilience, and quality of life after group and individu…

This study tested whether long-term exposure to a special light can improve sleep and memory in 73 people with mild cognitive impairment or mild Alzheimer's disease living at home. Participants used the light in their homes, and researchers measured changes in sleep quality and c…

This study tested whether a special lighting intervention could help people with mild to moderate Alzheimer's disease and type 2 diabetes sleep better and improve their metabolism. 61 participants living in assisted living facilities were exposed to either the special light or a …

This study tested whether a low-level magnetic therapy device, used at home, is safe and practical for people with Long COVID who have memory and thinking problems. Thirty adults with persistent cognitive issues after COVID-19 used the device daily for 4 weeks, then were followed…

This study aimed to understand what kind of support and information people with advanced bladder cancer need. Researchers asked 93 patients with incurable bladder cancer to fill out surveys and join focus groups. The goal was to create a tool that doctors can use to better addres…

This study looked at whether text message reminders help people over 55 with normal thinking skills follow a daily morning light routine. The light is meant to help reset the body's internal clock. Twenty healthy adults took part, and researchers measured their light exposure and…

This study measured pressure inside the kidney during surgery to remove kidney stones. It compared two types of tubes: one with suction and one without. The goal was to see if suction helps keep pressure at safe levels and improves stone removal. Twenty-one adults with kidney sto…

This study looked at 75 emergency room patients who had a non-fatal opioid overdose. Researchers measured the amount of xylazine, a veterinary sedative sometimes mixed with opioids, in their blood and tested urine strips for detection. The goal was to better understand how common…

This study tested a web-based app called STOMA Care to see if it is practical and helpful for bladder or colorectal cancer patients getting ostomy surgery and their caregivers. The app provides information and tools to improve stoma care knowledge, skills, and emotional well-bein…

This study looked at 108 adults having surgery for kidney stones. Doctors compared using a special balloon catheter versus a standard tube to see which one better stops small stone pieces from falling into the ureter. The goal was to find out if the balloon tool offers any advant…

This study tested a new online tool called the Personal Patient Profile for Bladder Cancer (P3-BC) to help patients facing bladder removal surgery make better decisions with their doctors. 24 adults with bladder cancer participated to see if the tool was easy to use and helpful. …

This study looked at how eating and fasting affect self-control in women with and without bulimia nervosa. Researchers used brain scans and computer tasks to see differences in behavior and brain activity. The goal was to better understand what drives bulimia symptoms. 100 adult …

This study involved 104 adults who needed a pleuroscopy, a procedure where doctors look inside the chest and take tissue samples from the lung lining. The goal was to find out how many samples are needed to make an accurate diagnosis without taking too many. Researchers counted t…

This small study tested a new iPad-based light technology (Circadian OS) to see how it affects melatonin, the hormone that controls sleep. Ten healthy adults over 30 were exposed to the light, and researchers measured changes in their melatonin levels and how sleepy they felt. Th…

This study looked at how cannabidiol (CBD) is absorbed and processed in 24 healthy adults. Researchers measured CBD levels in blood and urine to understand its safety and how the body handles it. The goal was to gather basic information, not to treat any disease.

This study looked at how the brain and body change during hypnosis. Fifty healthy adults completed a standard hypnosis test while wearing sensors to measure brain waves and other signals. The goal was to collect data that will help create a machine learning tool to recognize when…

This study looked at 15 people with a rare genetic condition called DDX3X syndrome, which often causes intellectual disability and sometimes autism. Researchers used interviews, play-based assessments, and genetic tests to better understand the condition. The goal was to gather k…

This study tested whether a newer heart medication (sotagliflozin) reduces blood clot formation better than an older one (empagliflozin) in 17 healthy volunteers. Each person took both drugs at different times, and researchers measured clot size and platelet activity. The goal wa…

This study looked at over 9,400 patients who had liver surgery to see if a less invasive approach leads to better outcomes. Researchers checked things like death within 30 days, serious infections, and whether patients needed to come back to the hospital. The goal was to understa…

This completed study looked at ways to increase diversity in cancer clinical trials, focusing on breast, liver, and prostate cancers. Researchers worked with communities, doctors, and scientists in New York City to find better ways to include people of color and underserved group…

This study looked at how the heart and lungs work in people with Chronic Fatigue Syndrome (ME/CFS) and how that relates to post-exertional malaise (PEM), a worsening of symptoms after activity. About 80 participants completed two days of maximal exercise tests, and those with low…