Icahn School Of Medicine At Mount Sinai

This study tests whether home-based health coaching can help people with COPD better manage their symptoms and avoid hospital visits. Researchers will enroll 300 adults, mostly from low-income and minority communities, and provide coaching on medication use, breathing exercises, …

This study looks at whether adding a coping skills program to standard biologic medication can improve emotional well-being and disease remission in people with early Crohn's disease. About 170 adults diagnosed within the last 5 years and starting a new biologic will be randomly …

This study looks at whether community health workers can help emergency room patients with high blood pressure connect to local services that address social needs like food or housing. Fifteen adults with uncontrolled high blood pressure will be enrolled. Researchers will track h…

This study tests whether the drug ritlecitinib can help people with keloids — thick, raised scars that grow beyond the original wound. About 30 adults will receive the drug after keloid removal surgery. The goal is to see if the drug lowers the chance of the keloid returning and …

This study tests a combination of two drugs, sacituzumab govitecan and cisplatin, in people with ovarian or endometrial cancer that has come back but still responds to platinum-based treatments. The goal is to find the safest dose and see how well the drugs shrink tumors. About 5…

This study tests a combination of two drugs, abemaciclib and bicalutamide, for people with a specific type of advanced breast cancer (AR-positive, HER2-negative) that has spread. The goal is to find the best dose and see if the combination helps control the cancer. About 42 adult…

This study tests whether combining two drugs (atezolizumab and bevacizumab) with a type of internal radiation (Y-90) can shrink liver tumors enough for patients to become eligible for a liver transplant. About 40 adults with hepatocellular carcinoma (HCC) will receive this combin…

This study tests whether a 'Metabolic Diet' can help women with anorexia nervosa maintain a healthy weight after they've regained weight. Twenty adult women who have recently reached a normal weight will follow the diet with a dietitian's guidance for 10 weeks. Researchers will m…

This study tests if dupilumab can help children aged 6 to 17 with moderate to severe alopecia areata regrow hair. About 76 participants will receive either the drug or a placebo for 48 weeks, followed by an open-label extension. The main goal is to measure changes in scalp hair l…

This study looks at whether following the MIND diet—a mix of Mediterranean and DASH diets—can protect the brain and improve symptoms in people with multiple sclerosis (MS). About 100 adults with MS will either follow the diet for one year or continue their usual eating habits. Re…

This study tests an oral medication, deucravacitinib, in 20 adults with two types of scarring hair loss (CCCA and FFA). Participants take one pill daily for 48 weeks. The goal is to see if the drug reduces inflammation and scarring in the scalp, potentially stopping hair loss pro…

This study tests whether low-dose methotrexate, a safe and inexpensive arthritis drug, can help people with certain blood cancers (polycythemia vera, essential thrombocythemia, and myelofibrosis). About 54 adults will take the drug alongside their current treatment to see if it s…

This study tests if rinsing the new bladder or urine pouch with a chlorhexidine antiseptic during and after bladder cancer surgery can prevent urinary tract infections. About 23 adults having bladder removal and reconstruction will participate. The main goal is to see if urine is…

This study tests a special catheter that both drains fluid and gently irrigates the brain to remove blood after a hemorrhage. It aims to lower pressure and speed up recovery compared to standard drainage. About 17 adults with intraventricular hemorrhage will be enrolled. The goal…

This study tests a special tube (CardioGard Embolic Protection Cannula) that may catch debris during high-risk heart valve surgery, potentially preventing strokes, kidney injury, and confusion after the operation. About 842 adults aged 60 and older having certain heart valve proc…

This study is testing a device that sends mild electrical pulses to the vagus nerve in the neck, paired with physical therapy, to help people who had a stroke months or years ago. The goal is to see if this approach can safely improve arm and leg movement. About 40 adults with ch…

This study tests two treatments—MTC01 and FMT—for people with repeat C. diff infections. About 60 adults will receive one of four treatment options. The main goal is to check safety and see how well each treatment prevents the infection from coming back within 8 weeks.

This study tests a daily pill called abrocitinib for people with Down syndrome who have eczema or a type of hair loss. About 56 participants will take the drug for up to 60 weeks to see if it safely controls their skin or scalp condition. The goal is to manage symptoms, not cure …

This study tests whether the drug reparixin can help people with myelofibrosis, a serious bone marrow cancer. It is for patients with advanced disease who cannot take or refuse standard JAK inhibitor treatment. About 26 adults will take reparixin pills three times daily for 6 mon…

This study tests a cream called delgocitinib on adults with two types of scarring hair loss (LPP and CCCA). The goal is to see if it is safe and how it affects certain markers in the scalp. About 30 people will use the cream twice a day for 48 weeks.

This study tests whether giving a mix of hormone therapy (ADT), a drug called darolutamide, and the immunotherapy pembrolizumab before prostate removal surgery can reduce or eliminate cancer left behind. After surgery, patients continue pembrolizumab for about a year. The trial e…

This study tests whether adding cannabidiol (CBD) to standard opioid addiction treatment can reduce cravings and prevent relapse. Researchers will enroll 450 adults with opioid use disorder who are already on methadone or buprenorphine. Participants will receive CBD or a placebo …

This early-stage study tests a new drug called alnuctamab in 21 people with moderate to severe lupus that hasn't improved with usual therapies. The drug aims to control the disease by targeting and reducing certain immune cells. The main goals are to check safety and see if it he…

This study tests whether a low dose of sirolimus (rapamycin) can help adults with Long COVID feel better. About 80 people will receive either the drug or a placebo. The main goal is to see if it improves their overall health and quality of life.

This study looks at whether adding a blood thinner to standard aspirin therapy helps prevent strokes and blood clots in people who develop a new irregular heartbeat after coronary bypass surgery. About 3,200 adults who had bypass surgery and then experienced atrial fibrillation w…

This study tests a new FDA-approved scanner that gives doctors a fast, detailed view of the prostate surface during surgery to find leftover cancer cells. The goal is to see if this method saves at least 20 minutes compared to the current technique. About 78 men with intermediate…

This study tests a new way to check for bleeding after stroke surgery using a special ultrasound through a clear skull implant. It aims to see if this method is as accurate as a CT scan, which is the current standard but is expensive and time-consuming. About 25 adults who had a …

This study looks at whether a continuous glucose monitor (CGM) worn on the skin can accurately diagnose gestational diabetes in pregnant people. About 150 participants between 18-50 years old will wear the monitor and also take the standard glucose tolerance test. If successful, …

This study looks at whether a special PET/CT scan (rhPSMA-7.3) can find more serious prostate cancers in men who are currently monitoring their low-risk cancer. About 120 men will get both the new scan and a standard MRI before a biopsy. The goal is to see if the PET/CT helps doc…

This study tests whether an upright MRI can effectively screen for prostate cancer in men at risk. Researchers will compare the upright MRI to standard PSA tests and traditional MRI scans. About 550 men will participate, and their comfort during the scan will also be assessed. Th…

This study compares two approaches to prevent calcium oxalate kidney stones from coming back after surgery. 80 adults who have had a procedure to remove large stones will be randomly assigned to receive either a standard preventive treatment or a treatment tailored to their urine…

This study explores whether music therapy can help children with depression build resilience and ease symptoms. Twenty children will attend 11 music therapy sessions, with some also attending recitals to discuss performance anxiety and self-expression. The goal is to see if these…

This study tests whether adding a drug called Suzetrigine to standard pain relief can lower the amount of opioids needed after weight-loss or heart surgery. About 235 adults will take part. The goal is to reduce pain and opioid use, which can have serious side effects.

This study tests a non-invasive device that stimulates the vagus nerve before meals in teens and young adults (ages 14-22) with anorexia or similar eating disorders. Over 4 weeks, participants receive either real or sham stimulation to see if it boosts meal satisfaction, calorie …

This study tests whether a gentle brain stimulation technique called tDCS can lower cravings in people with cocaine addiction. About 120 adults will receive the stimulation while doing thinking tasks, and brain scans will track changes. The goal is to see if this approach can hel…

This study tests whether giving a small dose of ephedrine before a combined spinal-epidural (a common type of labor pain relief) can reduce the chance of a non-worrisome but common fetal heart rate pattern called Category II. About 100 women in labor will receive either ephedrine…

This study compares two medications, epinephrine and dexmedetomidine, added to standard spinal anesthesia for planned cesarean sections. The goal is to see which one provides longer pain relief and faster recovery of movement. The study involves 62 pregnant women aged 18-55 who a…

This study tests a wearable device called the Sana Pain Reliever (Sana PR) to see if it can reduce chronic pain in people with Post-treatment Lyme Disease Syndrome. The device uses flashing lights and tones while measuring heart rate. About 20 participants will use it at home for…

This study tests a noninvasive brain-training technique called neurofeedback in 30 women with bulimia nervosa. Using a wearable headband that measures brain activity, participants receive real-time feedback while eating to improve self-control. The goal is to see if this training…

This study tests whether a personalized, sensor-based exercise program can reduce symptoms like palpitations and shortness of breath in people with atrial fibrillation (AF). Researchers will enroll 120 adults with paroxysmal AF who are not very active. Participants will use a dig…

This study tests whether tocilizumab, a drug that blocks inflammation, can help people with major depression who have lost interest or pleasure in things (anhedonia). About 20 adults with depression and signs of immune activation will receive the drug for 8 weeks, while 20 health…

This study tests whether a specific lighting schedule can help multiple myeloma patients undergoing their first stem cell transplant. Two hundred participants will receive either a special light treatment or standard light, and researchers will measure sleep quality, inflammation…

This study tests two different ways of positioning patients during surgery for stones in the upper part of the ureter. One position uses a slight head-down tilt to keep stones from moving back into the kidney, while the other tilts the patient to help clear stones from the kidney…

This study tests a type of talk therapy called Meaning-Centered Psychotherapy for caregivers of people with advanced cancer. The goal is to see if it helps caregivers feel more meaning and purpose in life, and reduces stress, anxiety, and depression. About 200 caregivers will rec…

This study tests whether two HIV antiviral drugs, Truvada and Selzentry, can reduce symptoms in adults with Long COVID. Researchers think hidden viral activity may cause ongoing symptoms. 90 participants will take one of the drugs or a placebo daily for 90 days, and their health …

This study tests whether dronabinol, a drug made from cannabis, can help reduce chronic pain and inflammation in adults with sickle cell disease. About 60 participants will receive either dronabinol or a placebo to see if it improves pain and quality of life. The goal is to find …

This study tests whether virtual reality can improve treatment for Mal de Débarquement Syndrome (MdDS), a balance disorder causing constant rocking or swaying sensations. Two hundred adults with MdDS will receive a 5-day therapy using VR headsets, with some receiving additional t…

This study compares two common labor-inducing drugs, misoprostol and pitocin, in 300 pregnant people with a BMI of 30 or higher. Both drugs are given along with a balloon catheter. The goal is to see which drug leads to a faster delivery and whether it increases the chance of a v…

This study tests whether a new pain medication called Suzetrigine can help people who have knee replacement surgery feel less pain and need fewer opioids. About 235 adults will be randomly assigned to get either Suzetrigine or a placebo before surgery. The goal is to see if the d…

This study tests a new mental training technique called cognitive reappraisal training for people with borderline personality disorder (BPD). The goal is to help them manage intense emotions by learning to mentally step back from upsetting situations. Researchers will use brain s…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can reduce the intense irritation people with misophonia feel from specific sounds. Sixty adults who are hypersensitive to certain sounds will receive two TMS sessio…

This study compares two different programs to help female Veterans who have experienced military sexual trauma or intimate partner violence and also have a brain injury. The goal is to see which program works better at improving emotion regulation and reducing PTSD symptoms. Abou…

This study tests whether a special flickering light, used for two hours each morning, can improve memory and sleep in people with mild cognitive impairment or early Alzheimer's. About 120 participants will be randomly assigned to one of four light conditions for 8 weeks. The goal…

This pilot study looks at whether a community navigator can help Black and Latina women with metastatic breast cancer access supportive services like palliative care. The program aims to reduce distress and symptom burden. About 67 women will take part, and the study will check i…

This study looks at whether a recreational ballet program can help children with autism spectrum disorder (ASD) improve their movement and coordination. Researchers will enroll 32 children aged 6 to 12 with an ASD diagnosis who are not currently taking ballet. The program lasts 1…

This study tests whether a nerve block called a rectus sheath block can reduce pain and the need for strong painkillers after heart surgery. About 75 adults having heart surgery with chest tubes will be randomly assigned to receive the block or not. Researchers will measure pain …

This study is testing whether combining a gentle nerve stimulation (taVNS) with a robotic tilt table can safely help people with long-term consciousness disorders after brain injury. Fifteen participants will undergo a 12-week rehabilitation program. The goal is to see if this pa…

This study tests lumbrokinase, an enzyme that may break down blood clots, in 120 adults with Long COVID, post-treatment Lyme disease syndrome, or ME/CFS. Participants rate their overall health before and after treatment. The goal is to see if lumbrokinase can improve quality of l…

This study is testing whether a non-invasive device that stimulates the vagus nerve, combined with arm exercises, can safely help improve movement in teenagers with spastic cerebral palsy. Ten participants aged 12-17 will receive the treatment and be monitored for side effects an…

This study tests whether one hour of morning light therapy each day for four weeks can improve sleep quality and reduce inflammation in adults with ulcerative colitis who have active inflammation and poor sleep. Thirty participants will wear a sleep tracker, complete surveys, and…

This study tests whether adding ketorolac (an anti-inflammatory) to the standard lidocaine numbing shot reduces pain during office hysteroscopy, a procedure to look inside the uterus. About 60 women with abnormal bleeding will be randomly assigned to get either the combined numbi…

This study tests a new live video program called Resilient Together for Dementia (RT-D) for couples where one partner was recently diagnosed with dementia. The goal is to help both partners manage emotional distress and prevent long-term struggles. The study will include 24 coupl…

This study tests a virtual reality (VR) headset that uses circadian reset technology to improve sleep and reduce binge eating in 40 adults with binge eating disorder. Participants use the headset for 10 minutes twice daily for one month. Researchers will compare changes in binge …

This study tests whether adding a peer coach to standard treatment helps teens with eating disorders and their parents. About 70 teens aged 12-18 and their parents will be randomly assigned to receive either parent coaching plus patient materials, or patient coaching plus parent …

This study is testing a self-hypnosis program that runs on a virtual reality headset to help people with HIV manage chronic pain. About 25 adults with HIV and long-term pain will use the software at home for 21 days. Researchers will check if it is safe, easy to use, and if it he…

This study will enroll 100 people with relapsed multiple myeloma to analyze their cancer's genetic makeup. Participants provide blood, cheek swab, and tumor samples during standard care. Researchers use advanced sequencing to find genetic changes and potential drug targets. The g…

This study aims to better understand what drives compulsivity in people with obsessive-compulsive disorder (OCD). Researchers will use brain wave recordings (EEG) and computer models to look beyond simple habit theories. They will compare 50 adults with OCD to 50 healthy voluntee…

This study aims to learn more about how changes in the FOXP1 gene affect development, language, and behavior in children and adults. Researchers will use interviews, play-based assessments, and genetic tests to better understand these rare conditions. The study is open to people …

This study looks at how cannabidiol (CBD), a non-intoxicating cannabis compound, affects stress responses in 160 young adults aged 18-25 who experienced early life adversity. Researchers will use brain scans, blood and saliva tests, and stress questionnaires to understand CBD's i…

This study follows 40 liver transplant patients after they leave the hospital, using a continuous glucose monitor to track their blood sugar levels. The goal is to see how blood sugar control relates to complications like wound healing or other transplant outcomes. Participants m…

This study looks at whether giving teens same-day results for gonorrhea and chlamydia tests helps them also get tested for HIV and start PrEP, a medicine that prevents HIV. About 6,460 teens aged 16-24 will take part at three clinics. The goal is to see if faster testing makes it…

This study is testing a new, non-invasive brain activity monitor in 100 intensive care unit patients who are on breathing machines and sedatives. The device, placed on the forehead, aims to track delirium, sedation, and agitation levels. Researchers will compare its readings with…

This study looks at how the brain makes decisions about self-control in women with bulimia nervosa. Researchers will use brain scans to see if eating changes how the brain predicts and values effort. The goal is to understand why binge eating and purging cycles continue, not to t…

This study checks if a simple 3-ounce water swallow test can safely tell if a person with a tracheostomy is aspirating (liquid going into the lungs). Researchers will compare the water test results with the standard camera-based swallow exam. About 80 adults with a tracheostomy w…

This study tests two new Siemens imaging prototypes during minimally invasive surgery to remove brain bleeds. Researchers will collect CT scans before, during, and after the procedure to see if the tools help doctors better detect remaining bleeding and blood flow changes. The go…

This study aims to create a large registry of 800 patients receiving biologic therapies for immune diseases. Researchers will collect medical records, blood samples, and other data to better understand how these treatments work and to develop new ways to predict patient responses…

This study checks how well pulse oximeters (the clip-on finger sensors that measure oxygen levels) work in children with congenital heart disease, especially those with darker skin. Researchers will measure actual skin pigment using a special device and compare it to the oximeter…

This study aims to understand how the brain processes rewards in people with depression. Researchers will record brain activity from specific areas in 10 adults with both depression and epilepsy while they perform a gambling task. The goal is to identify abnormal brain signals th…

This study looks at how educational workshops can reduce stress and burnout and improve resilience in community health workers and frontline workers in New York City. About 168 participants will take surveys before and after the program. The goal is to learn what works best to su…

This study is testing whether therapy sessions done over video (telehealth) can help teens and young adults who are at high risk for developing psychosis. About 72 people aged 14 to 25 will be randomly assigned to group, family, or individual therapy. The goal is to see if these …

This study looks at whether social isolation causes faster aging and more health problems in people with schizophrenia. Researchers will follow 650 participants (500 with schizophrenia and 150 siblings) over time, tracking medical records and social behavior. The goal is to under…

This study looks at whether microplastics in the body can worsen gut inflammation and change the gut bacteria in pregnant women with Crohn's disease. Researchers will measure microplastics in stool samples and analyze the microbiome. The goal is to understand how environmental po…

This study aims to uncover the genetic and molecular causes of fibromuscular dysplasia (FMD) and related artery conditions (SCAD and CvAD). Researchers will compare tissue and blood samples from 600 patients and healthy volunteers to identify key genes and biological pathways. Th…

This early-phase study looks at how the antibiotic vancomycin changes gut bacteria and immune cells in people newly diagnosed with multiple sclerosis (MS). Researchers want to understand the connection between gut health and brain inflammation. About 12 participants will take van…

This study looks at whether the amount of vitamin D in your blood affects your chance of developing thyroid problems while receiving immunotherapy for cancer. Researchers will measure vitamin D and thyroid function in 17 adults before and during standard cancer treatment. The goa…

This study aims to better understand acute kidney injury and chronic kidney disease by analyzing kidney tissue from 1000 volunteers. Researchers will use advanced technology to identify different disease types and find new targets for therapies. The goal is to pave the way for pe…

This study creates a registry of people with pancreatic diseases or a high risk for pancreatic cancer, such as those with a family history or certain genetic mutations. Researchers will collect medical information and blood samples to study how these conditions develop over time.…

This study is testing whether a special in-ear device can safely and accurately detect seizures by measuring brain waves. Researchers will first test the device on 5 healthy volunteers, then on 10 people with epilepsy who are already scheduled for a standard scalp EEG. The goal i…

This study looks at how eating a lot of fructose (a type of sugar) changes the bacteria in your gut and increases risks for fatty liver, type 2 diabetes, and obesity. Thirty adults who have trouble digesting fructose will eat either a high-fructose or high-glucose diet for 12 day…

This study follows 200 pregnant women with serious mental illness to see how taking antipsychotic medication affects their mental health and their baby's development. Researchers will compare women who take antipsychotics, other psychiatric drugs, or no medication. The goal is to…

This study explores whether rhythmic light therapy can improve brain function and memory in people with mild cognitive impairment. Twenty participants will attend three one-hour sessions with different light patterns while their brain activity is measured. The goal is to see if c…

This study looks at whether community health workers and special training for doctors can help more people with kidney disease get on the transplant waiting list. About 5 patients will take part. The goal is to see if addressing social needs and reducing bias can speed up the pro…

This study looks at how things in the environment, like chemicals, might affect how thyroid cancer grows. Researchers will collect small blood samples and have participants fill out questionnaires to track exposures. The goal is to understand why some thyroid cancers become more …

This study compares two procedures—thoracentesis (draining fluid with a needle) and pleuroscopy (a camera-guided biopsy of the lung lining)—in 98 adults with suspected cancer-related pleural effusion. The goal is to see which approach provides a usable tissue sample and leads to …

This early-stage study tests whether combining exercise, a natural supplement called spermidine, and either rapamycin or lamivudine is safe and doable for current or former smokers aged 65-80. The goal is to see if this mix can reduce inflammation and slow aging. Only 22 particip…

This study looks at how a damaged vagus nerve may cause gut bacteria overgrowth and inflammation in people with HIV. Researchers will test if a drug called pyridostigmine or vagus nerve stimulation can help. About 207 adults with well-controlled HIV will participate over 5 years.

This study looks at whether a continuous glucose monitor (CGM) worn during late pregnancy and for two weeks after birth can help predict which women with gestational diabetes will have abnormal blood sugar after delivery. Currently, only a small number of women complete the stand…

This study tests a memory support program for Chinese American adults aged 55 and older with mild cognitive impairment (MCI). The program, originally designed for English speakers, will be adapted for Mandarin and Cantonese speakers. The goal is to see if the program is practical…