Icahn School Of Medicine At Mount Sinai

This study tests whether a special 'Metabolic Diet' can help women with anorexia nervosa keep a stable weight after they have regained weight. Twenty adult women who recently reached a normal weight will work with a dietitian to follow the diet for 10 weeks. Researchers will moni…

This study tests whether low-dose methotrexate, a safe and inexpensive drug used for decades in arthritis, can help people with certain blood cancers called myeloproliferative neoplasms (MPNs). The trial will include 54 adults with polycythemia vera, essential thrombocythemia, or…

This study tests whether combining two drugs (atezolizumab and bevacizumab) with a type of internal radiation (Y-90) can shrink liver tumors enough for patients to qualify for a liver transplant. It includes 40 adults with liver cancer who either need to shrink tumors to meet tra…

This study tests whether adding a structured coping skills program to standard biologic medication helps people with Crohn's disease achieve better emotional well-being and disease remission. It involves 170 adults diagnosed with Crohn's for less than 5 years who are about to sta…

This study is testing if rinsing a piece of bowel with an antiseptic solution during and after bladder removal surgery can prevent urinary tract infections. The rinse is used during the operation and then continued daily for 10-21 days afterward. Researchers will check if this he…

This early-stage study is testing whether a combination of exercise, a natural supplement called spermidine, and either rapamycin or lamivudine can safely reduce inflammation and slow aging in people aged 65-80 who smoke or used to smoke. The main goal is to see if the approach i…

This study tests an oral drug called reparixin in 26 adults with myelofibrosis, a rare bone marrow cancer. Participants have advanced disease and cannot take or refuse standard JAK inhibitor treatment. The goal is to see if reparixin can shrink the spleen, improve blood counts, a…

This study tests whether giving a three-drug combination (hormone therapy, a targeted pill, and an immunotherapy) before prostate removal surgery, followed by more immunotherapy after surgery, can reduce or eliminate cancer left behind. It enrolls 40 men with high-risk prostate c…

This study tests whether a home-based health coaching program can help people with COPD better manage their symptoms and avoid hospital visits. The program includes breathing exercises, medication guidance, and early treatment for flare-ups. Researchers will enroll 300 adults fro…

This study looks at whether adding a special PET/CT scan (rhPSMA-7.3) to the usual MRI can better find aggressive prostate cancers in men with low-risk cancer who are on active surveillance. About 120 men will get both scans before a confirmatory biopsy. The goal is to see if the…

This study tests whether a rectus sheath block—a type of nerve block—can reduce pain and the need for strong painkillers after heart surgery. About 75 adults having heart surgery with chest tubes will be randomly assigned to receive the block or not. Researchers will measure pain…

This study tests whether morning light therapy can improve sleep and reduce inflammation in adults with ulcerative colitis who have poor sleep quality. For four weeks, participants will use a light box for one hour each morning while wearing a sleep tracker. The goal is to see if…

This study tests a wearable device called the Sana Pain Reliever (Sana PR) to see if it can reduce chronic pain in people with Post-treatment Lyme Disease Syndrome. The device uses flashing lights and tones while measuring heart rate. 30 participants will use it at home for 15 mi…

This study tests a noninvasive brain-training technique called neurofeedback in 30 women with bulimia nervosa. Using a wearable headband, participants receive real-time feedback on brain activity while eating, aiming to improve self-control and reduce binge-eating and purging epi…

This study tests whether a safe, non-invasive brain stimulation technique called tDCS can reduce cravings in people with cocaine addiction. About 120 adults will receive the stimulation while doing thinking tasks, and their brain activity will be scanned. If it works, this could …

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can help people with misophonia tolerate trigger sounds better. Sixty adults who are hypersensitive to specific sounds will receive two TMS sessions targeting the pa…

This study tests a new mental exercise called cognitive reappraisal training for adults with borderline personality disorder. The training teaches people to step back from upsetting thoughts and feelings. Researchers will use brain scans to see if the training changes emotion-rel…

This study tests whether two HIV antiviral drugs can reduce symptoms in adults with Long COVID. Researchers think hidden viral activity may play a role. 90 participants will take either Truvada, Selzentry, or a placebo daily for 90 days, and their health will be tracked using a s…

This study tests whether adding a peer coach to standard treatment helps teens aged 12–18 with eating disorders. 70 participants will be randomly assigned to either parent coaching plus patient materials, or parent materials plus patient coaching. The goal is to see if coaching i…

This study tests whether a new pain medication called Suzetrigine can help people who have knee replacement surgery feel less pain and need fewer opioids. About 235 adults will be randomly assigned to get either the new drug or a placebo before surgery. The main goal is to see if…

This study tests whether tocilizumab, a drug that blocks a protein linked to inflammation, can help people with major depression who have lost interest or pleasure in life. About 60 adults with depression and signs of immune activation will receive the drug for 8 weeks. Brain sca…

This study looks at how eating influences the brain's ability to exert self-control in women with bulimia nervosa. Researchers will use brain scans and computer tasks to see if predictions about control are altered after eating. The goal is to understand what drives the cycle of …

This study is collecting kidney tissue samples from 1,000 people with acute kidney injury or chronic kidney disease, including those with type 1 diabetes. Researchers will analyze the tissue to identify different disease subtypes and find new targets for treatments. The goal is t…

This study compares two ways to diagnose fluid buildup around the lungs in people with suspected cancer: a needle drainage (thoracentesis) or a scope biopsy (pleuroscopy). Researchers want to see which method provides a better tissue sample and leads to a faster cancer diagnosis …

This study is creating a large registry of 800 people receiving biologic medications for immune conditions like autoimmune diseases or primary immune deficiencies. Researchers will collect medical records, blood samples, and other data to learn how these treatments work and how t…

This study looks at whether a program called Building Community Resilience (BCR) can help reduce stress and burnout in community health workers and frontline staff in New York City. About 168 participants will attend educational workshops and complete surveys to measure changes i…

This study looks at how things in the environment, like chemicals, might affect thyroid cancer. Researchers will collect small blood samples and have participants fill out questionnaires. The goal is to understand if certain exposures make thyroid cancer more aggressive. 500 adul…

This study follows 200 pregnant women with severe mental illness to see how taking antipsychotic medication affects their mental health and their baby's development. Researchers will compare women who take antipsychotics, other psychiatric drugs, or no medication. The goal is to …

This study looks at how the brain works in people with obsessive-compulsive disorder (OCD) compared to healthy volunteers. Researchers will use brain wave recordings (EEG) and computer models to understand the thinking patterns behind compulsions. The goal is to find better ways …

This study explores whether combining a gentle nerve stimulation (taVNS) with a robotic tilt table can help people with long-term consciousness disorders after brain injury. Fifteen participants will try this 12-week therapy to see if it is safe and practical. The goal is to gath…