Icahn School Of Medicine At Mount Sinai

This study tests a new coil system (Kaneka iED) for treating wide-necked brain aneurysms, which are bulging blood vessels that can rupture. Researchers will enroll 50 patients and follow them for 18 months to see how well the coils block blood flow to the aneurysm, how many coils…

This early-phase study tests a new three-drug combination (iberdomide, elotuzumab, and dexamethasone) in adults with multiple myeloma that has returned or stopped responding to prior therapies. The goal is to find the safest dose and see if the combination can shrink tumors. Abou…

This study tests a program called NeuroResource Facilitation for people with brain injury who are about to leave prison. The goal is to see if this support helps them avoid being arrested or sent back to prison. Over 1,000 adults with brain injury and thinking problems are taking…

This study tests whether a lower dose of chemotherapy and radiation, given after an initial round of chemo, can effectively control advanced HPV-positive throat cancer while causing fewer side effects. About 43 adults with this condition are taking part. The goal is to see if thi…

This early study tests an oral herbal formula called E-B-FAHF-2 in 7 adults with mild-to-moderate Crohn's disease. The main goal is to see if it is safe and tolerable, and to explore whether it can help control inflammation. Researchers also check how the formula affects immune c…

This early-phase study tests whether injecting a long-lasting nerve block (lidocaine and alcohol) around the prostate can slow cancer growth in 12 men with high-risk localized prostate cancer. The main goal is to find a safe dose and check for side effects. If successful, this ap…

This study compares a lower dose of radiation to the standard dose for people with advanced HPV-positive throat cancer. The goal is to see if the lower dose works just as well while causing fewer side effects. The trial enrolled 23 participants with stage 3 or 4 disease that has …

This study is testing a new surgical technique called transanal total mesorectal excision (taTME) for rectal cancer. The approach works from the bottom up to make removing the tumor easier and potentially safer. About 100 adults with rectal cancer will have this surgery to see if…

This study tests a new, high-resolution camera that takes 3D pictures of the back of the eye. It aims to see tiny details in the retina of people with age-related macular degeneration (AMD). The goal is to help doctors diagnose AMD earlier and track the disease better. About 50 a…

This study compares a shortened MRI scan to the standard ultrasound for detecting liver cancer in 820 adults with liver cirrhosis. Researchers will also check if blood markers can help spot cancer early. The goal is to see if the faster MRI is more accurate and cost-effective for…

This study compares two MRI contrast agents, gadopiclenol and gadoxetate, to see which one provides clearer images of the liver and better detects liver lesions (including tumors). About 75 adults with chronic liver disease or liver lesions will each receive both contrast agents …

This study tests a special MRI scan to see how well it can measure liver scarring (fibrosis) in people with a fatty liver disease called MASH. Researchers will compare the MRI results with standard tests like ultrasound and blood work. The goal is to find a noninvasive way to dia…

This study tests a digital toolkit called eNav to help more people get screened for colorectal cancer. The toolkit includes a website with information and support, plus text message reminders and instructions. About 400 patients from health centers will use the toolkit to see if …

This study tests a program called SaMBA-WTC that helps World Trade Center responders with asthma manage their condition better. About 56 adults with uncontrolled asthma will either get the program or standard care. The goal is to see if the program improves asthma control, medica…

This study explores whether adding guided meditation through a virtual reality headset at the start of voice therapy can help people with voice disorders learn and retain treatment better. About 60 participants with voice problems and anxiety will use the TRIPP app on a Meta Ques…

This study tests a device called MIRA that uses lights and sounds to create calming experiences for patients and staff in a neurosciences intensive care unit (ICU). The goal is to see if it is safe, practical, and helpful for improving physical, mental, and cognitive health after…

This study tests a new way to deliver palliative care that adjusts the care team based on how well a person is doing. People with advanced heart failure or certain cancers will receive a community health worker, and if symptoms get worse, a social worker, nurse, or doctor is adde…

This study tests whether providing palliative care at home can improve symptom management for people with advanced dementia and reduce stress for their family caregivers. About 150 patient-caregiver pairs in New York City will receive either the in-home care program or standard c…

This study looked at whether telling women about calcium buildup in their breast arteries (found during a mammogram) could encourage them to take steps for better heart health. About 5,500 women took part, and a smaller group received extra information about their results. The go…

This study looks at whether a dose of oxytocin (a natural hormone given as a nasal spray) can help people with borderline personality disorder (BPD) trust others more during a game. Researchers compare their behavior and brain activity to healthy adults. The goal is to understand…

This study follows 150 adults aged 65 and older who are receiving radiation therapy for cancer. Researchers will track how well patients complete treatment, changes in their daily function, and any side effects they report. Participants fill out surveys and do physical and thinki…

This study looks at over 1,000 adults with asthma to better understand different types of the disease. Researchers will use medical records and genetic information to see how asthma behaves with various treatments. No new treatments are tested; the goal is to gather knowledge to …

This study looks at whether a single dose of methylphenidate (a mild stimulant) can help people with cocaine use disorder weaken their drug-related memories. About 51 adults will have brain scans and skin response tests while recalling drug cues after taking either the medication…

This study looks at over 2,000 World Trade Center workers and volunteers to understand how their lungs were affected by the 9/11 attacks. Researchers will review chest CT scans and breathing tests to find links between exposure, symptoms, and lung diseases like COPD. The goal is …