Brain study tests drug to erase cocaine cravings

NCT ID NCT05978167

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 24 times

Summary

This early-phase study looks at whether a single dose of methylphenidate (a mild stimulant) can help people with cocaine use disorder weaken their drug-related memories. About 51 adults will undergo brain scans and skin tests while recalling drug cues after taking either the medication or a placebo. The goal is to understand how the brain processes these memories, which could lead to better therapies for addiction.

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Contacts and locations

Locations

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

Conditions

Explore the condition pages connected to this study.