Centre Hospitalier Universitaire De Nice

This study tested whether a drug called apremilast, combined with UVB light therapy, can help restore skin color in people with vitiligo. Eighty adults with vitiligo covering at least 10% of their body took part. The goal was to see if the combination works better than light ther…

This study tested whether adding the cholesterol-lowering drug atorvastatin to standard UVB light therapy works better than light therapy alone for adults with active vitiligo. 28 people took part over 6 months. The goal was to see if the combination could reduce the amount of sk…

This pilot study tested whether metformin, a common diabetes drug, could shrink tumors in 20 people with advanced melanoma that had stopped responding to standard treatments. The goal was to see if the drug could cause partial or complete tumor shrinkage. The study is complete, a…

This study tested whether adding avdoralimab (an antibody that blocks a specific immune signal) to strong steroid creams helps people with bullous pemphigoid, a blistering skin disease common in people over 70. Fifteen participants received the combination, and researchers measur…

This study tested whether low doses of IL2, a protein that helps regulate the immune system, could treat severe alopecia areata (patchy hair loss). 44 adults with at least 50% scalp hair loss that did not respond to standard treatments received either IL2 or a placebo. The goal w…

This study tested whether starting treatment very early in vitiligo can stop the disease from spreading and improve skin color return. 51 people with different stages of vitiligo received a combination of light therapy and low-dose steroids for 6 months. The goal was to see if th…

This study tested a gel called ingenol mebutate (Picato) on 20 people with a very early form of melanoma on the face who could not or chose not to have surgery. The gel aims to destroy cancer cells by causing inflammation and cell death. The main goal was to see if the cancer com…

This study looked at whether a blood test measuring two proteins (sFlt-1 and PlGF) can help doctors better decide if a pregnant woman with suspected pre-eclampsia needs to be hospitalized. Pre-eclampsia is a serious condition that can harm both mother and baby, but current diagno…

This study tested a new device that measures muscle mass while sitting, without sticky electrodes, to diagnose sarcopenia (age-related muscle loss). Researchers compared it to the standard DXA scan in 72 older adults. The goal was to see if the simpler method works just as well f…

This study looked at whether a simple blood test for circulating tumor cells (CTCs) can help detect lung cancer earlier in people at very high risk—smokers and ex-smokers over 55 with COPD. Researchers combined the blood test with low-dose CT scans over three yearly screenings. T…

This study looked at whether a blood test (liquid biopsy) can detect a specific genetic change (ALK rearrangement) in lung cancer cells circulating in the blood. The goal is to see if this non-invasive method works as well as a traditional tissue biopsy to guide treatment decisio…

This study tested whether using virtual reality (VR) during medical procedures can help elderly patients feel less pain and anxiety. 87 people over age 60 took part. Researchers compared VR relaxation scenes to usual care to see if it made a difference.

This study looked at whether a specific type of muscle training (eccentric exercise) can improve walking ability in people with knee osteoarthritis. 40 adults aged 40-85 with knee arthritis took part. The main goal was to see if this exercise program helps them walk farther in a …

This study looked at whether a special lung-opening maneuver during weight-loss surgery can help patients breathe easier afterward. Researchers studied 230 obese adults having bariatric surgery. They measured if the technique reduced shortness of breath and the need for extra oxy…

This study tested whether injecting etanercept directly into inflamed joints (knee, wrist, ankle, elbow) can safely ease pain in people with rheumatoid arthritis. 34 adults with at least 6 months of RA and a painful flare lasting 2 weeks or more took part. The goal was to compare…

This study tested a new cream for melasma, a skin condition causing dark patches on the face. It compared a standard treatment (Kligman's trio) to a version with a different active ingredient (thiamidol) that may be safer. 40 adults with melasma took part to see if the new cream …

This study tested whether a drug called esketamine causes fewer disturbing side effects than standard ketamine when used for severe pain in the emergency room. 74 adults with severe acute pain received either esketamine or ketamine through an IV. The main goal was to see how many…

This study looked at how teenagers with autism or schizophrenia understand emotions, intentions, and social situations compared to healthy teens. Researchers used brain wave tests and cognitive tasks to find similarities and differences. The goal was to learn more about these con…

This study tested how accurately a robot called Neuromate, using its Neurolocate system, can target specific brain areas during deep brain stimulation surgery. Researchers compared the robot's aimed point to the actual point reached in 18 patients with Parkinson's disease, dyston…

This study looked at 150 adults with thoraco-lumbar spine injuries to see if adding an emergency MRI to the standard CT scan changes how doctors treat them. The goal was to find fractures only visible on MRI and see if treatment plans shifted. Results help understand the value of…

This study looked at 20 adults with acute myeloid leukemia (AML) who cannot have strong chemotherapy. They received a standard drug combination (azacitidine + venetoclax). Researchers measured venetoclax levels in the blood to see if they relate to how well the drug works and its…

This study looked at special proteins called immune semaphorins in people with fatty liver disease and NASH. The goal was to learn how these proteins might control inflammation in the liver and fat tissue. Researchers studied 148 obese patients to find new markers or future treat…

This study looked at 40 adults having laparoscopic bowel surgery to see if adding diluted epinephrine to a numbing medicine (ropivacaine) used in a TAP block (a type of pain shot) lowers the peak amount of the medicine that enters the blood. The goal is to improve safety by reduc…

This study looked back at 420 patients who had jaw surgery to fix dental deformities or misaligned bites. Researchers compared those who prepared with clear aligners versus those who used traditional metal braces. The goal was to see if one method made the surgery itself easier o…

This study looked at whether blue light from computer or TV screens can darken melasma, a common skin condition causing dark patches on the face. Twelve women with melasma had one side of their face exposed to simulated screen blue light for 5 days, while the other side was not e…

This study followed 29 infants who had bronchiolitis (a serious chest infection) in their first year to see if it leads to asthma by age 3. Researchers tested their lung function and did allergy skin tests at several checkpoints. Many families dropped out, but among those who sta…

This study looked at how apathy (lack of interest or motivation) influences different types of fatigue in older adults with mild neurocognitive disorders. Researchers compared 30 apathetic and 30 non-apathetic participants aged 65-85. Participants wore activity trackers for a wee…

This study involved 45 kidney transplant patients and aimed to learn more about how the drug Advagraf (a type of tacrolimus) is processed by the body after transplantation. Researchers measured drug levels in the blood to find better ways to determine the right dose. No new treat…

This study looked at how the brain controls hand movements and speech in 20 healthy young adults. Using brain scans, researchers searched for shared brain networks. The goal is to help stroke patients recover speech by using hand exercises.

This study aims to create a detailed map of the cells lining the airways in healthy people. By analyzing gene activity in individual cells from different parts of the respiratory tract, researchers hope to better understand how these cells interact and how they change in diseases…

This study looked at blood samples from 20 adults with relapsed membranous nephropathy, a kidney condition. Researchers tested different immune-modulating drugs in the lab to see how they affect the balance of certain immune cells (Th17 and Treg). The goal was to gather informati…

This study looked at how sleep disturbances in Alzheimer's disease are linked to daily activity cycles. Researchers tracked sleep, behavior, and activity in 70 older adults with mild memory problems and healthy volunteers. The goal was to better understand why sleep problems happ…

This study looked at skin samples from 170 people with psoriasis, atopic dermatitis, or healthy skin to understand how a protein called Lyn is involved in inflammation. Researchers measured Lyn levels and activity, along with other inflammatory markers. The goal was to see if a s…

This study looked at 77 adults who had a cardiac arrest outside the hospital. Researchers measured lactate (a waste product) in the blood during CPR to see if it could help predict whether the heart would start beating again on its own. The goal was to find a simple tool to guide…

This study looked at gene activity in the lining of the nose and airways of 44 healthy and allergic adults. The goal was to understand how these tissues differ in people with allergic rhinitis or mild asthma. Researchers collected samples to compare genetic profiles, aiming to im…

This study looked at whether a special kidney scan (scintigraphy) can find kidney problems earlier than standard tests in children and young adults with sickle cell disease. 18 participants were checked during their annual visit. The goal is to prevent serious kidney damage later…