SARS-COV-2 INFECTION

This study tested updated versions of the Pfizer-BioNTech COVID-19 vaccine in over 1,400 healthy people who had already received prior COVID-19 vaccines. Participants received a single booster dose of one of several new vaccine formulas designed to target newer virus variants. Th…

This study tested an extra dose of the PHH-1V COVID-19 vaccine in 241 adults with weakened immune systems (due to HIV, kidney disease, or autoimmune conditions) who had already received other COVID-19 vaccines. The goal was to see if the booster increased their antibody levels ag…

This study tested a booster shot called BIMERVAX in 242 teens aged 12 to 17 who had already received a different COVID-19 vaccine. The goal was to see if it was safe and boosted their immune system against the virus. Researchers measured antibody levels and tracked any side effec…

This study tested whether a single injection combining a licensed COVID-19 vaccine and a licensed flu vaccine is safe and triggers a strong immune response. It involved 644 healthy adults aged 50 and older. The main goal was to check for side effects and measure antibody levels a…

This study tested a new booster vaccine for COVID-19 in over 4000 healthy adults who had already been vaccinated. The goal was to see if the new booster works as well as a current vaccine and is safe. Participants received one shot and were monitored for immune response and side …

This early-stage study tested a new COVID-19 vaccine called ABNCoV2 in 45 healthy adults who had never had COVID-19. The goal was to check the vaccine's safety and see how well it triggers the immune system. Researchers gave two doses, with or without an immune booster (adjuvant)…

This large study tested whether giving extra doses (boosters) of the Pfizer-BioNTech COVID-19 vaccine to healthy people who already had the vaccine was safe and helped prevent COVID-19. Over 16,000 people took part, and the study looked at different booster schedules and doses. T…

This early-stage trial tested a new COVID-19 vaccine given as a nasal spray. The goal was to see if it is safe and triggers an immune response. 27 healthy adults aged 18 to 50 received two doses. The vaccine uses a weakened virus to deliver a piece of the COVID-19 spike protein.

This study tested a single dose of a new COVID-19 vaccine (AVX/COVID-12) in 158 healthy adults who already had some immunity from prior infection or vaccination. The vaccine was given either as an injection or a nasal spray to see which route works better and is safe. Researchers…

This early-stage study tested three new self-amplifying RNA vaccines against COVID-19 in 72 healthy adults, some already vaccinated and some not. The main goal was to check safety and how well the vaccines triggered an immune response. Results help researchers decide which vaccin…

This study tested three different batches of the Novavax COVID-19 vaccine to make sure they all work the same. About 900 adults aged 18 to 49 who had already been vaccinated took part. Researchers measured their immune response and checked for safety issues.

This study tested the safety and immune response of different COVID-19 booster vaccines in about 1,900 people aged 12 to 64 in Kenya, Democratic Republic of Congo, and Rwanda. It included both people with and without HIV. The goal was to see if mixing vaccine types (like using on…

This study tested updated mRNA vaccines designed to protect against new SARS-CoV-2 variants (like XBB.1.5, JN.1, and KP.2). About 1,051 healthy people aged 12 and older received a single shot. Researchers monitored side effects and measured immune responses for six months to see …

This large study tested the safety and effectiveness of the Pfizer-BioNTech mRNA vaccine (BNT162b2) in nearly 47,000 healthy volunteers aged 12 and older. Participants received two doses of the vaccine or a placebo, and the trial showed the vaccine was highly effective at prevent…

This early-stage trial tested a new RNA-based COVID-19 booster vaccine in 383 healthy adults who had already received a COVID-19 vaccine. The main goal was to see if the vaccine was safe and to find the best dose. Researchers measured side effects and immune responses after one o…

This study tested how well two updated COVID-19 vaccines (Novavax and Pfizer mRNA) protect adults from getting sick. About 1,188 people who had already received at least two mRNA vaccine doses took part. Participants were randomly assigned to get either the Novavax or Pfizer vacc…

This study tested how well the Moderna COVID-19 vaccine worked in adults with a higher risk of severe illness, including people living with HIV. Over 14,000 participants in Eastern and Southern Africa received either two or three doses, depending on whether they had a prior COVID…

This study checked how safe and effective the COVID-19 medicine PAXLOVID is in real-world use. Over 3,300 people aged 12 and older who took PAXLOVID were watched for 28 days. Researchers tracked side effects and whether the infection got worse. The goal was to make sure the drug …

This completed Phase 2 trial tested combinations of drugs in people with COVID-19. Only 4 people took part. The goal was to see if the drugs helped patients recover faster and lower the risk of death. The study used a flexible master protocol to guide both hospital and home treat…

This study tested new portable sensor platforms to quickly and cheaply detect three types of infections: SARS-CoV-2 (the virus that causes COVID-19), Pseudomonas aeruginosa bacteria, and Leishmania infantum parasites. Researchers used blood and respiratory samples from 149 adult …

This study looked at whether testing saliva (spit) is as good as the standard nose swab for finding COVID-19. Over 5,000 people provided both a nose swab and a saliva sample. The goal was to see if saliva testing could make screening easier and more comfortable while still being …

This study tested a new, fast, and affordable COVID-19 test called TestNPass. Researchers checked how well it finds the virus using nose swabs from 400 adults. The goal was to see if it is accurate enough to use widely, helping people get results quickly without needing lab equip…

This study looked at whether taking moderate (4,000 IU) or high (10,000 IU) doses of vitamin D daily could lower the risk of getting COVID-19 compared to a low dose (400 IU). About 1,475 adults from the Chicago area took part for 9 months. Researchers tracked who got a confirmed …

This study looked at whether two drugs, hydroxychloroquine and azithromycin, could prevent COVID-19 infection in hospital workers who were exposed to the virus. 122 hospital staff without COVID-19 took one of the drugs or a placebo for 40 days. The main goal was to see if fewer p…

This study tested an experimental antiviral pill called S-217622 in over 2,000 adults with mild to moderate COVID-19 who were not hospitalized. Participants started the pill within 3 days of symptoms. The goal was to see if the pill could shorten symptom duration and lower virus …

This study looked at whether the antiviral drug remdesivir can reduce symptoms of Long COVID. 73 adults with confirmed Long COVID received the drug for five days, and researchers checked their symptoms and health before and after treatment. The main goal was to see if this approa…

This completed study looked at how the COVID-19 pandemic changed the health and daily lives of people aged 75 and older, as well as their caregivers. Researchers analyzed medical records and interviewed groups to understand new care needs. The goal is to improve healthcare servic…

This study looked at placentas and umbilical cord blood from 68 women who had COVID-19 while pregnant. Researchers checked for changes in the placenta's structure, genes, and signs of inflammation. The goal was to understand how the infection might affect the baby's health and de…

This study gathered kidney tissue, blood, and urine samples from 90 adults hospitalized with COVID-19 who also had acute kidney injury. Researchers aimed to better understand how COVID-19 affects the kidneys and to identify potential treatments. Participants provided samples duri…

This study involved 36 healthy adults aged 18 to 40 who were deliberately exposed to the Omicron BA.5 strain of the COVID-19 virus. The goal was to find a safe dose that causes infection in at least 40% of people and to monitor any side effects. Researchers tracked symptoms and v…

This study tracked 366 people in Japan who received Evusheld to treat or prevent COVID-19. Researchers monitored for side effects like allergic reactions and heart problems. The goal was to confirm the drug's safety in real-world use.

This early study tested a new PET/CT scan tracer in 5 adults who had recovered from COVID-19. The goal was to see if the tracer could find signs of lung damage. The study was small and focused on testing the method, not treating the disease.

This study checked if leftover COVID-19 virus in the nose is linked to ongoing brain fog and memory problems. Researchers compared 51 adults who had COVID-19 months earlier—some with brain fog, some without. They looked for virus in the nasal cavity and matched it to thinking dif…

This study followed over 1,000 people in the Dominican Republic to understand how COVID-19 spreads and how to control it. Researchers tracked symptoms, tested for antibodies, and checked handwashing habits. The goal was to learn more about the virus and find better ways to preven…

This study checked how many police officers in Bern, Switzerland had antibodies against COVID-19 over one year. About 1,024 officers volunteered to give blood samples at five different times. Researchers also looked at their risk of catching the virus at work and at home, and how…

This study aimed to understand why people have such different reactions to COVID-19 and influenza infections. Researchers collected detailed biological samples from 249 adults during and after their illnesses. By analyzing this data, they hoped to identify key factors that determ…