SARS-COV-2 INFECTION

This study tested a new vaccine designed to protect against the Omicron JN.1 variant of COVID-19. About 120 adults aged 65 and older, and teens and adults aged 12 to 64 with health conditions that increase COVID-19 risk, received one dose. Researchers checked how well the vaccine…

This study tested an updated RNA-based COVID-19 vaccine designed for the 2025-2026 season. It involved 774 participants aged 12 and older, including those 65+ and younger people with health conditions that raise their risk of severe COVID-19. Everyone received one shot, and resea…

This study tested updated versions of the Pfizer-BioNTech COVID-19 vaccine designed to target newer Omicron variants (XBB.1.5, JN.1, and KP.2). Over 1,000 healthy people aged 12 and older received a single dose. The main goals were to check safety and measure the immune response.…

This large study tested Moderna's COVID-19 mRNA vaccine in over 14,000 people living with HIV or other conditions that increase the risk of severe COVID-19. The goal was to see how well different vaccine doses prevent COVID-19. Participants received either the original or an upda…

This study tested whether three different manufacturing batches (lots) of Novavax's COVID-19 vaccine produce the same immune response and safety in adults. About 900 healthy adults aged 18 to 49 who had already been vaccinated received one of the three lots. The results help ensu…

This large study tested the safety and effectiveness of the Pfizer-BioNTech mRNA vaccine (BNT162b2) against COVID-19 in nearly 47,000 healthy volunteers aged 12 and older. Participants received two doses of the vaccine or a placebo, and the trial also explored booster doses and p…

This study tested a booster shot called BIMERVAX in 242 teenagers aged 12 to 17 who had already received a different COVID-19 vaccine. The goal was to see if it safely boosts their immune protection against the virus, including the Omicron variant. Participants were followed for …

This early-stage trial tested a new COVID-19 vaccine called ABNCoV2 in 45 healthy adults who had never had COVID-19. The vaccine uses a virus-like particle to train the immune system, and some doses included an adjuvant to boost response. The main goals were to check safety and m…

This study tested different COVID-19 booster vaccines (Janssen, Moderna, Pfizer, Novavax) in about 1,900 adolescents and adults aged 12 to 64 in Kenya, Democratic Republic of Congo, and Rwanda. Some participants had HIV, and others did not. The goal was to see if mixing vaccine t…

This early-stage study tested a new COVID-19 vaccine given as a nasal spray. It involved 27 healthy adults aged 18 to 50. The vaccine uses a weakened virus to teach the body to fight SARS-CoV-2. The main goal was to check safety and see if the vaccine triggers an immune response.

This early-stage study tested an experimental RNA-based COVID-19 booster vaccine in 383 healthy adults who had already received a COVID-19 vaccine. The goal was to find a safe dose and see how well the body's immune system responded. Researchers looked at side effects and immune …

This large Phase 3 trial tested whether giving healthy people who already received the Pfizer-BioNTech COVID-19 vaccine one or more extra doses (boosters) is safe and effective. Over 16,000 participants in several countries received either the original vaccine, a version adapted …

This study tested three new self-amplifying RNA vaccines against COVID-19 in 72 healthy adults, some already vaccinated and some not. The goal was to check safety and how well the vaccines boost the immune system. Results help decide which vaccine candidates to study further.

This Pfizer trial tested whether a single injection combining an updated COVID-19 vaccine and a flu vaccine is safe and triggers a strong immune response. The study involved 644 healthy adults aged 50 and older. Researchers measured side effects and antibody levels to see if the …

This study tested a single dose of a new COVID-19 vaccine (AVX/COVID-12) in 158 healthy adults who already had some immunity to the virus. The vaccine was given either as an injection or a nasal spray to see which route worked better and was safe. Researchers measured antibody an…

This study tested a new COVID-19 booster vaccine called AVX/COVID-12, made from a modified Newcastle disease virus (which affects birds). Over 4,000 healthy adults in Mexico who had already been vaccinated against COVID-19 received either the new vaccine or the AstraZeneca booste…

This study tested several updated mRNA COVID-19 booster vaccines in over 1,400 healthy adults who had already received prior COVID-19 vaccines. The goal was to see if these new boosters are safe and can improve the immune response against newer Omicron variants. Participants rece…

This study tested an extra dose of the HIPRA COVID-19 vaccine in 241 adults with conditions like HIV, kidney disease, or autoimmune disorders that weaken the immune system. The goal was to see if the booster raises antibody levels against virus variants and remains safe. Research…

This Phase 2 trial tested whether combining famotidine (Pepcid) and celecoxib (Celebrex) could help people with COVID-19 recover faster. Only 4 participants were enrolled, making it too small to draw firm conclusions. The study aimed to see if these drugs could reduce symptom sev…

This large Phase 3 study tested an antiviral pill called S-217622 in over 2,000 adults with mild to moderate COVID-19 who were not hospitalized. Participants started the drug within 3 days of symptoms. The main goal was to see if the drug shortens symptom duration compared to a p…

This study checked how well a new rapid test, TestNPass, can detect COVID-19 using a nose swab. It involved 400 adults at a hospital in France. The goal was to see if the test is accurate enough to replace slower PCR tests and provide a digital health pass.

This study tested whether saliva samples can detect the COVID-19 virus as well as the standard nose swab test. Over 5,000 people provided both nose swabs and saliva samples, which were compared using different detection methods. The goal was to see if a simpler, less invasive spi…

This study tested two new types of biosensor platforms to detect viruses, bacteria, and parasites in blood and respiratory samples. The goal was to see if these devices could be accurate, fast, and cheap alternatives to standard lab tests. Researchers enrolled 149 adults with or …

This study looked at whether taking different amounts of vitamin D could lower the risk of getting COVID-19. About 1,475 adults from the Chicago area took either a low (400 IU), moderate (4,000 IU), or high (10,000 IU) daily dose of vitamin D for 9 months. Researchers tracked who…

This study tested how well two different 2023-2024 updated COVID-19 vaccines (Novavax and Pfizer mRNA) protect adults from getting sick with COVID-19. About 1,200 adults who had already received at least two mRNA vaccine doses were randomly assigned to get either the Novavax or P…

This study tested whether hydroxychloroquine or azithromycin could prevent COVID-19 infection in hospital workers who were regularly exposed to the virus. 122 participants took one of the drugs or a placebo for 40 days. The study found no significant difference in infection rates…

This study tested whether the antiviral drug remdesivir could help people with Long COVID. 73 adults with confirmed Long COVID received five daily doses of the drug through an IV. Researchers measured how many people completed the treatment and tests, and how well they tolerated …

This study followed 324 people who had close contact with a confirmed COVID-19 case to see how long they shed the virus. Participants provided nasal swabs and reported symptoms over 12 days. The goal was to understand transmission risks and help shape public health policies.

This completed pilot study scanned the brains of 30 people who were hospitalized with COVID-19 and later reported memory, concentration, or organizational problems—often called 'brain fog.' Researchers used MRI and spectroscopy to look for changes in brain structure and chemistry…

This completed study looked at how often healthcare workers and first responders experienced short-term side effects (like fever or sore arm) after getting either the updated Novavax or Pfizer COVID-19 vaccine. About 660 adults who had at least one prior COVID-19 shot took part. …

This completed study collected blood, urine, and kidney tissue from 90 COVID-19 patients with acute kidney injury. Researchers aimed to build a biorepository and analyze samples to better understand how COVID-19 affects the kidneys. The goal is to speed up discoveries and improve…

This early-phase study tested a radioactive tracer called 18F-αvβ6-BP in 5 people who had recovered from COVID-19. The goal was to see if the tracer could highlight lung damage on PET/CT scans. Participants received the tracer intravenously and underwent imaging. The study only a…

This study looked at placentas from 68 women who had COVID-19 during pregnancy to see if the virus changes the placenta's structure or gene activity. Researchers also checked umbilical cord blood for signs of inflammation. The goal is to better understand how the infection might …

This study checked how safe Evusheld is for treating and preventing COVID-19 in Japanese patients. It included 366 people who got the drug in real-world settings. The main goal was to track side effects like allergic reactions and heart problems. The study is now complete and hel…

This study looked at 51 adults who had COVID-19 2 to 12 months earlier and still had brain fog or other thinking problems. Researchers checked if the virus was still hiding in the nose's smell center. They compared these patients to a control group to see if lingering virus is li…

This study involved 36 healthy adults aged 18 to 40 who were given a controlled dose of the Omicron BA.5 virus. The goal was to find a safe dose that causes infection in at least 40% of people, while monitoring side effects. This type of research helps scientists better understan…

This study looked at how many police officers in Bern, Switzerland had antibodies against COVID-19 over one year. About 1,024 officers volunteered to give blood samples at five different times. Researchers also asked about their work and home life to understand infection risks an…

This completed study enrolled over 1,000 people in the Dominican Republic to track how COVID-19 spreads and how to control it. Researchers provided some households with alcohol-based hand sanitizer and monitored handwashing habits, virus exposure, and vaccine attitudes. The goal …

This completed study collected blood, urine, and nasal swab samples from 249 adults—some with COVID-19, some with the flu, and healthy controls—at two time points. Researchers used a systems biology approach to analyze the data, aiming to understand why people respond differently…

This completed study from Pfizer looked at the safety and effects of the COVID-19 medicine PAXLOVID in over 3,300 people aged 12 and older. All participants took PAXLOVID twice a day for five days and were monitored for 28 days. The main goal was to track any side effects, includ…

This completed study looked at how the COVID-19 pandemic changed the health and daily lives of people aged 75 and older and their caregivers. Researchers analyzed medical records and interviewed participants to understand the impact of lockdowns, reduced physical activity, and so…