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New COVID booster vaccine shows promise in large trial

NCT ID NCT05710783

Completed ⭐️ VACCINE ⭐️ Sponsor: Laboratorio Avi-Mex, S.A. de C.V. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new COVID-19 booster vaccine called AVX/COVID-12, made from a modified Newcastle disease virus (which affects birds). Over 4,000 healthy adults in Mexico who had already been vaccinated against COVID-19 received either the new vaccine or the AstraZeneca booster. The goal was to see if the new vaccine triggers a similar immune response and is safe. The trial is now complete, and results are being analyzed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
AVX/COVID-12 vaccine (made from a modified Newcastle disease virus)
What this could lead to
If successful, this could provide a new booster option against COVID-19 that is safe and effective.
What could go wrong
This is a completed trial, but results are not yet published. The vaccine uses a novel virus vector, so its long-term performance is still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19 prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SARS-COV-2 INFECTION

Contacts and locations

Locations

  • CAIMED Investigación en Salud S.A. de C.V.

    Mexico City, Mexico City, 06760, Mexico

  • Centro Multidisciplinario para el Desarrollo Especializado de la Investigación Clinica en Yucatán S.C.P.

    Mérida, Yucatán, 97070, Mexico

  • Centro de Investigación Clínica Acelerada, S.C.

    Gustavo Adolfo Madero, Mexico City, 07369, Mexico

  • Centro de Investigación Clínica Chapultepec S.A. de C.V.

    Coyoacán, Mexico City, 04100, Mexico

  • Centro de Investigación Clínica del Pacífico, S.A. de C.V.

    Acapulco de Juárez, Guerrero, 39670, Mexico

  • Centro de Investigación y Avances Médicos Especializados / RED OSMO Cancún

    Cancún, Quintana Roo, 77506, Mexico

  • Clinical Research Institute S.C.

    Tlalnepantla, State of Mexico, 54055, Mexico

  • Jules Bordet Medical Service, S.C.P. / Khöler & Milstein Research

    Mérida, Yucatán, 97070, Mexico

  • Oaxaca Site Management Organization, S.C.

    Oaxaca City, Oaxaca, 68000, Mexico

  • Profesionales Médicos Desarrollados, S.C. (Instituto Veracruzano de Investigación Clínica)

    Veracruz, Veracruz, 91855, Mexico

  • Promotora Médica Aguascalientes, S.A. de C.V.

    Aguascalientes, Aguascalientes, 20230, Mexico

  • Sociedad Administradora de Servicios de Salud, S.C.

    Morelia, Michoacán, 58260, Mexico

  • Unidad de Atención Médica e Investigación en Salud, S.C.P.

    Mérida, Yucatán, 97070, Mexico

  • Unidad de Medicina Familiar No. 20 - IMSS

    Gustavo Adolfo Madero, Mexico City, 07760, Mexico

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