ANAL CANCER

This study tests a new immunotherapy for people with advanced HPV-related cancers (cervical, throat, anal, and others). Participants receive specially engineered immune cells designed to attack HPV-infected tumor cells, along with chemotherapy and a drug to boost cell activity. T…

This study looks at how well the drug T-DXd works in adults with advanced HER2-positive solid tumors that have spread and are not responding to other treatments. About 100 people will be followed to see if their tumors shrink and how long that lasts. The goal is to provide a trea…

This study tests whether giving a specific chemotherapy (mDCF) before the usual chemoradiotherapy can improve outcomes for people with advanced anal cancer (stages T3-4 or N1). About 310 adults with this condition will be randomly assigned to either the standard treatment or the …

This study tests whether giving a single dose of specially engineered immune cells (E7 TCR-T cells) before standard treatment (chemoradiation or surgery) can shrink or eliminate tumors in people with advanced HPV-related cancers. About 15 participants will have their own T cells …

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (carboplatin and paclitaxel) and radiation can completely eliminate early-stage anal cancer. About 23 adults with stage I to IIIA anal cancer will receive weekly chemo-immunotherapy plus…

This study tests whether using a vaginal dilator during daily pelvic radiotherapy can reduce the risk of vaginal narrowing (stenosis) in women with anal cancer. About 60 women will be randomly assigned to use the dilator during radiation or not. The goal is to see if this simple …

This study tests whether using virtual reality (VR) can reduce severe belly pain in people with digestive tract cancers. 360 participants will be split into three groups: one using skills-based VR, one using distraction VR, and a sham control group. Researchers will track pain, a…

This study looks at whether a simple blood test can find HPV DNA in people with HPV-related anal or cervical cancer who are getting radiation therapy. Researchers will take blood samples before, during, and after treatment to see if the virus's genetic material shows up and if it…

This study is collecting blood and tumor samples from 1100 people with various cancers (like head and neck, ovarian, and lung cancer) to learn how immune cells called T cells behave. The goal is to understand why some cancers are better at hiding from the immune system. Participa…

This study looks at how different types of HPV (human papillomavirus) are linked to anal cancer in China. Researchers will collect information from 300 patients to understand which HPV types are most common and how the disease affects people. The goal is to better describe the di…

This observational study looks at how radiotherapy for anal cancer affects women's vaginal and sexual health. About 80 women who completed chemoradiotherapy 6 to 36 months ago will have a gynecological exam, fill out questionnaires, and allow analysis of their radiation scans. Th…

This study follows up with 100 people who were part of the ANRS IPERGAY trial to see if certain HPV molecular signatures are linked to high-grade anal lesions or cancer 10 years later. Researchers will use high-resolution anoscopy to check for abnormalities. The goal is to better…

This study looks at how common anal cancer risk signs are in HIV-negative men who have sex with men (MSM) using PrEP. About 300 participants will answer health questions, provide an anal swab, and undergo a special exam called High-Resolution Anoscopy. The goal is to see how well…

This study looks at whether letting people collect their own anal samples at home can increase the number of high-risk individuals who follow through with clinic appointments for anal cancer screening. About 572 participants from Chicago, Houston, and Milwaukee will be involved. …

This study tests whether daily CT scans can help doctors see and protect the ovaries during pelvic radiation in women under 50 with various cancers. The goal is to keep radiation doses to the ovaries low enough to avoid early menopause and infertility. Ten participants will recei…

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…