Vertebral column disorder

This study is testing a new synthetic bone graft called FIBERGRAFT Aeridyan Matrix in people having lumbar spine fusion surgery. The graft is designed to help the bones heal together. Researchers will compare it to standard grafts in 316 participants across the US to see if it le…

This study tests a new device called LDGraft, which contains a protein that helps bone grow, for people with degenerative disc disease needing spinal fusion. Forty adults aged 22 to 80 will be randomly assigned to receive either LDGraft or standard bone graft during surgery. The …

This trial tests a new implantable device called ThecaFlex DRx in 90 people with spinal muscular atrophy (SMA) who cannot receive standard spinal injections due to spine problems or other risks. The device is placed under the skin and delivers the medication nusinersen directly i…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can lower inflammation and pain after major spine surgery. About 50 adults having long-segment spinal fusion will be randomly assigned to receive the stimulation or standard care. Researchers…

This trial tests whether transferring gut bacteria from a healthy donor (fecal microbiota transplantation, or FMT) can reduce disease activity in people with axial spondyloarthritis (axSpA) who haven't fully responded to biologic therapy. Participants receive a single enema with …

This study tests a special sealant called Immiseal that is applied during brain or spine surgery to prevent leaks of cerebrospinal fluid. It is used along with standard repair methods to create a watertight seal. The study follows adults aged 18 to 75 who need dural repair after …

This study tests a new device called the VersaTie system, used during spine fusion surgery to help prevent a complication called proximal junctional failure. The trial will enroll 225 adults with spinal deformities like scoliosis or kyphosis who need surgery on five or more verte…

This study compares carbon fiber and titanium screws in people with cancer that has spread to the spine. The goal is to see if carbon screws cause fewer imaging problems, making it easier to plan radiation therapy and spot cancer return. About 226 adults will take part, and the s…

This study looks at a special type of stitch (STRATAFIX) already approved by the FDA for closing wounds after brain or spine surgery. Researchers want to see if it helps wounds heal better and with fewer problems. About 160 adults having brain or spine surgery will take part. The…

This study is testing a moldable bone graft material called OssiMend Bioactive Moldable in people having lumbar spine fusion surgery for degenerative disc disease. The goal is to see if it helps the bones fuse together successfully and reduces pain and disability. About 120 adult…

People who suffer spinal cord injuries face a high risk of dangerous blood clots, and doctors usually prescribe enoxaparin, a daily injection, to prevent them. This trial compares enoxaparin with apixaban, an oral blood thinner, in 60 adults recovering from spinal cord injury at …

This study tests whether using a special MRI scanner combined with a radiation machine (MR-LINAC) during spinal radiation therapy can improve treatment results and quality of life. About 40 adults with cancer that has spread to the spine will receive stereotactic radiosurgery whi…

This study will track 600 adults with neck or back pain who are already scheduled to receive pharmacopuncture (herbal medicine injections) as part of their care. The key difference is that doctors will use an ultrasound device to guide the needle, aiming to avoid nerves and blood…

This study tests whether an ultrasound-guided retrolaminar block (a numbing injection near the spine) can lower the amount of opioids patients need after lumbar spine fusion surgery. Forty-four adults will be randomly assigned to receive either the active block or a sham injectio…

This study looks at whether using a special stationary bike while lying in bed, the day after spine surgery, helps people get moving sooner. About 88 adults having elective spine surgery will either get standard care or add a 30-minute in-bed cycling session. Researchers will tra…

This study is testing whether a one-time infusion of stem cells and exosomes from donated umbilical cord blood can safely reduce chronic lower back pain and improve daily function. About 100 adults with long-term back pain will receive either the stem cell treatment or a placebo …

This study tests whether applying natural medicinal mud (peloidotherapy) before specialized scoliosis exercises can reduce pain and improve quality of life in young adults aged 20-40 with mild to moderate scoliosis. Researchers will compare standard exercise alone to exercise plu…

This study looks at whether using walking sticks can help people with a forward-leaning spine (sagittal imbalance) walk longer distances. Thirty-five adults aged 50 and older who do not currently use walking sticks will test them for 3 months. Researchers will measure how far the…

This study tests whether a special 3D exercise program (the Schroth method) can improve back muscle endurance, sleep, and quality of life in 60 adolescents aged 12-18 with hyperkyphosis (excessive rounding of the upper back). Participants will do the exercises for at least 3 mont…

This study tests a multidisciplinary rehab program (Revita) for people with long-term low back pain or spine problems. The program combines physical therapy with psychological, social, or educational support over up to 36 sessions. Researchers will measure changes in disability, …

This study tests whether adding dexamethasone or dexmedetomidine to a standard nerve block (with ropivacaine) can better control pain after lower back surgery. 150 adults scheduled for elective lumbar spine surgery will be randomly assigned to one of three groups. The main goal i…

Researchers are following up with about 50 patients who received the IntraSPINE implant for lower back pain caused by degenerative disc disease. The goal is to see whether the implant still provides meaningful improvement in function and pain at least 9 years after surgery. They …

This trial investigates whether a single dose of magnesium sulfate, given during spinal fusion surgery, changes the signals used to monitor nerve health. The study includes adults undergoing open thoracolumbar fusion with planned neuromonitoring. Researchers will measure magnesiu…

This study will follow 1,000 people receiving Medtronic spinal or cranial devices during routine surgery. Researchers will track outcomes like fusion success, pain relief, and device safety for up to two years. The goal is to gather real-world data on how these already-approved p…

This study tests a wearable chest patch that continuously measures heart rate, breathing, oxygen levels, blood pressure, and temperature in patients recovering from major spinal surgery. Researchers want to see if nurses and patients find the device easy and useful compared to st…

This study is a registry that collects information from children and teens up to age 21 who are having spine surgery with robotic and navigation tools. The goal is to track how accurately screws are placed and how much radiation patients and surgeons receive. No new treatment is …

This study follows 15,000 people with various spinal conditions (like stenosis, fractures, infections, or cancer spread) to see how their quality of life changes over 5 years. Participants fill out questionnaires about their health and daily activities. The goal is to understand …

This study follows 5,000 adults with spinal conditions to track their pain, work status, and quality of life over time. Participants fill out questionnaires before and after treatment. The goal is to learn which treatments work best for different types of spinal disease.

This study is watching over 7,000 spine surgery patients to see if using a robot to place screws is more accurate and leads to fewer repeat surgeries than the traditional method. Researchers will also track how quickly surgeons learn to use the robot. The goal is to gather real-w…

This study is tracking 500 adults with complex spinal deformities (like scoliosis or kyphosis) who undergo minimally invasive surgery. Researchers will measure pain, disability, and quality of life over time to find the best surgical approaches and reduce complications. The goal …

This study is following 1,500 adults with complex spine problems (like scoliosis or kyphosis) who are having surgery. Researchers want to learn which surgical methods work best and how to reduce complications. Participants will complete surveys about pain and quality of life, and…

This study is testing how accurately the eCential Robotics robot helps surgeons place screws in the spine. About 45 people aged 5 and older who need spine surgery will take part. The robot uses 3D imaging and navigation to guide screw placement, and the study will measure screw a…

This study tests a new method to help patients understand complex spine or prostate surgeries before they agree to them. Instead of just reading a form, patients watch multimedia content and answer questions to check their understanding. The goal is to see if this approach makes …

This study aims to understand why some people have complications after spinal surgery. Researchers will measure bone strength, muscle health, and other markers in 200 adults undergoing spine surgery. The goal is to find better ways to predict and prevent problems like pain or the…

This study is testing whether a new questionnaire, called the Postural Habits and Awareness Scale (PHAS), reliably measures how aware people with postural hyperkyphosis (rounded upper back) are of their posture. 128 participants will fill out the questionnaire twice, two weeks ap…