Schizophreniform disorder

This completed trial in Xishui, China, tested a community-based program for 3,571 adults aged 35 and older who were at high risk for COPD and had mental health symptoms. The program included lung function tests, digital mental health support, smoking cessation help, and health ed…

This study looked at 6 people with schizophrenia who were already taking a combination of two long-acting injectable medications: Abilify Maintena and Rexulti. Researchers tracked their symptoms and side effects over 6 months to see how well the combo worked in everyday life. The…

This completed study tested Igalmi, a fast-dissolving film placed under the tongue, for managing frequent agitation in people with schizophrenia or bipolar disorder. 29 adults received the drug as needed for 7 days in a clinic. Researchers looked for signs that the drug might sto…

This study tested whether delivering coordinated specialty care (CSC) via telehealth works as well as standard in-person care for young people (ages 16–35) with early psychosis. Over 12 months, researchers tracked hospitalizations and engagement in 74 participants. The goal was t…

This study tested whether a team-based care model can help people with both opioid use disorder and mental health issues like depression or anxiety. 254 adults in primary care received either full collaborative care for both conditions or just mental health support. The goal was …

This completed study tested whether a Mediterranean diet could improve metabolic syndrome markers in 30 hospitalized adults with psychiatric conditions. Participants followed either a Mediterranean diet or a standard hospital diet for 8 weeks, then switched. Researchers measured …

This pilot study tested a counseling program called the Teen Marijuana Check Up, adapted for young adults (ages 13–35) who have early psychosis and use cannabis. The program uses motivational interviewing and personalized feedback over two sessions to help participants reduce or …

This study looked at whether a special brain scan called 18F-FDG PET can help doctors tell the difference between cognitive problems caused by psychiatric conditions versus neurodegenerative diseases like Alzheimer's. Researchers studied 20 adults with cognitive impairment who ha…

This study tested whether mindfulness training can prevent relapse in people with psychosis. 152 participants who were in remission were randomly assigned to either mindfulness training or standard education. Researchers tracked them for 12 months to see who had a relapse.

This study looks at whether adding a physical activity education program to adapted exercise helps people with mild memory or thinking problems more than exercise alone. Thirty-four participants will be followed for six months to measure changes in activity level, thinking skills…

This study tested a counseling program called Youth Friendship Bench SA for young women aged 18-25 in South Africa who had symptoms of depression, anxiety, or stress. The program included individual and group counseling sessions, plus optional text reminders. The goal was to see …

This study looked at whether a weekly hour of adapted physical activity for 12 weeks could improve self-esteem and motivation in 17 older adults with mild to major cognitive disorders like Alzheimer's. Researchers measured changes in self-esteem, motivation, and apathy. The goal …

This Phase 3 trial tested a sublingual film containing dexmedetomidine (BXCL501) to quickly reduce agitation in 380 adults with schizophrenia or related disorders. Participants received either the drug or a placebo film, and researchers measured changes in agitation symptoms over…

This study tested whether adding levetiracetam (a seizure medication) to standard antipsychotics helps people with early psychosis who still have symptoms. 65 participants took either the drug or a placebo for 12 weeks. The goal was to see if it reduces psychotic symptoms and pro…

This study tested a brief, two-session therapy program for young adults (ages 18-35) who had recently started early psychosis services. The program, adapted from a US-based intervention called 'Just Do You,' aimed to improve treatment engagement and recovery by addressing barrier…

This study tested whether a non-invasive brain stimulation technique called tDCS can reduce auditory hallucinations in people with psychotic disorders. Twenty-four participants received the stimulation while researchers measured changes in hallucination severity and brain activit…

This study tested whether a 4-week program using active video games (exergames) on the Nintendo Switch could help adults with mental illness feel better and stay motivated. Twelve participants were split into two groups: one played exergames, the other continued their usual routi…

This study tested whether a 4-month gym exercise program helps young adults (18-35) taking antipsychotic medication for psychosis or mood disorders feel better in their daily lives. 226 participants were randomly assigned to either continue their usual care or add gym workouts. R…

This study tested whether taking part in art activities like theatre, dance, visual arts, music, or cinema can improve mental health. 541 adults with psychiatric diagnoses were randomly assigned to either an art program or a waitlist. Researchers measured changes in depression an…

This study tested whether forest therapy—mindful walking, sun bathing, hugging trees, and meditation—could improve symptoms and reduce inflammation in 80 adults with psychotic disorders. Half received forest therapy plus standard care for 8 weekly sessions; the other half receive…

This study tested a 10-week peer support program called 'Paths to everyday life' for adults with mental health difficulties. Participants were randomly assigned to either the peer support group plus usual services, or usual services alone. The goal was to see if the program impro…

This pilot study tested a mobile app called iCanChange in 100 young adults (ages 18-35) with psychosis and cannabis use disorder. The app uses motivational interviewing and cognitive behavioral therapy techniques through short interactive modules. The main goal was to see if the …

This study tested two mobile health (mHealth) strategies to help people with schizophrenia manage their symptoms. 299 participants used smartphone tools to track and improve issues like depression, anxiety, and insomnia. The goal was to see if these digital tools could make a rea…

This study tested whether a 4-week virtual reality (VR) training program could improve thinking skills in 62 people with depression, bipolar disorder, or psychotic disorders like schizophrenia. Participants practiced daily-life tasks in VR, such as cooking and shopping, guided by…

This study tested a 10-session dog-assisted therapy program for 60 adults with severe mental illness. The goal was to see if spending time with trained therapy dogs could help participants build positive mental health behaviors like communication and socialization. Researchers me…

This study tested two different 2-month training programs to help veterans with psychosis improve their social interactions and quality of life. 113 veterans took part. The goal was to see which training worked better for everyday social situations.

This study tested an investigational medication called BXCL501 (dexmedetomidine) given as a film under the tongue for episodes of agitation in people with schizophrenia, schizoaffective disorder, or bipolar disorder. The trial included 452 adults aged 18-75 and compared the drug …

This study tested a 6-week supervised physical activity program for university students dealing with mild-to-moderate mental health issues like stress, anxiety, or feeling isolated. Seventeen students took part in group exercise sessions including walking, aerobics, and strength …

This completed study tested whether a mild electrical current applied to a specific brain region (the right superior temporal sulcus) could reduce hallucinations in 12 adults with psychosis. Participants received transcranial electrical stimulation while researchers measured chan…

This completed study from the National Institute of Mental Health looked at nearly 5,000 people with schizophrenia or related disorders, along with their siblings. The goal was to find genes linked to the illness and see how they affect brain function. This research helps scienti…

This study investigates how a medication called lorazepam, which boosts the calming brain chemical GABA, changes emotional brain activity in people with psychosis. Participants aged 16–60 with conditions like schizophrenia or bipolar disorder, along with healthy volunteers, will …

This study tested whether a 10-week recovery program, co-led by a peer with mental illness and a professional, is feasible for people with mental illness in Taiwan. Twenty participants completed the program, which focused on recovery concepts, strengths, and goal setting. Researc…

This study tested a web application called PRATICAdr 2.0, designed to help healthcare workers on sick leave due to common mental disorders like depression or anxiety return to work. The app helps coordinators track progress and improve communication. Researchers compared workers …

This study tested a new way to improve mental health services for people with psychosis in Uganda. Instead of just doctors making decisions, people who have experienced psychosis were trained to help at home, in the community, and at clinics. The goal was to see if this approach …

This study tested whether artificial intelligence (AI) can realistically simulate conversations between a therapist and a person with a mental health problem. Researchers used 520 simulated sessions to see if the AI could follow proper therapy techniques. The goal is to use these…

This study looked at how thinking skills and brain activity differ in people who self-harm compared to those who don't. Researchers interviewed 316 adults and gave them thinking tests, with some also having brain scans. The goal was to better understand self-harm to help create m…

This study tested a program called Recovery Bridge, where trained peer specialists (people with lived experience of mental illness) helped veterans leaving a psychiatric hospital connect to outpatient care and community life. Fifteen veterans took part to see if the program was f…

This completed study looked at 400 people with both heart disease and a mental health condition (like depression or anxiety). Researchers used questionnaires, blood tests, and imaging to find shared risk factors and biological markers. The goal was to better understand how these …

This study tested whether an anti-stigma training program for healthcare providers improves attitudes toward people with mental illness or substance use problems. About 485 staff and clients from six health centers took part, with three centers receiving the training and three no…

This study looked at how well patients, their family members, and doctors agree when rating agitation episodes in people with bipolar disorder or schizophrenia. Thirty-three adults received a treatment called BXCL501, and researchers compared different questionnaires to see which…

This study looked at how often insomnia occurs in people hospitalized for psychiatric conditions. Researchers checked 427 patients at 11 hospitals in Switzerland and Germany. They also explored whether age, gender, or type of disorder made insomnia more likely.

This study tested whether sending text message reminders and support to young people with psychosis after an emergency room visit helps them attend their first early psychosis appointment. 186 participants were enrolled. The goal was to see if a low-cost, youth-friendly approach …

This study tested a program called NAVIGATE, which provides coordinated care for youth and young adults (ages 14-35) who have had a first episode of psychosis. The goal was to see if NAVIGATE helps improve recovery, reduce hospital stays, and lower healthcare costs compared to st…

This study tested a new digital tool called CBTpro that uses artificial intelligence to help therapists improve their skills in cognitive behavioral therapy for psychosis (CBTp). Over 600 participants, including therapists and their clients with conditions like schizophrenia or b…

This study tested a program called CRAFT-EP, which helps families support a relative with early psychosis and substance use (like alcohol or cannabis). The program was delivered entirely through video calls. Researchers measured family members' depression and anxiety to see if th…

This study looked at how a supplement called N-acetylcysteine (NAC) affects brain chemicals and thinking in 88 adults with schizophrenia or related disorders. Participants took tryptophan to raise a brain chemical called kynurenic acid, then had cognitive tests and brain scans. T…

This study tested an 8-month program called 'Meaningful Activities and Recovery' (MA&R) for people with mental illness. The program helps people take part in activities that matter to them. 139 adults took part to see if the program improves activity engagement, recovery, and qua…

This study tested a program called iCOT to improve how occupational therapy interns communicate with patients in mental health settings. The program included online training and feedback from patients, supervisors, and experts. Researchers compared interns who received iCOT to da…

This study tested whether a systematic phone call from a medical student, supervised by a general practitioner, could reduce hospitalizations in patients with chronic heart or mental health conditions during the COVID-19 lockdown in France. Over 22,000 patients aged 70 and older …

This study looked at how people aged 15-45 with early psychosis process information about their surroundings, called state representation. Researchers tested two types of cognitive training and measured changes in thinking and brain activity using computer tasks and scans. The go…

This study tested different parts of a family navigation program to see which ones work best for helping low-income and minority families get mental health services for their children. 312 children aged 3-12 who showed signs of behavioral health concerns took part. The goal was t…

This study used artificial intelligence to predict how engaged people would be in online therapy and how much their symptoms would improve. Researchers analyzed data from over 6,600 adults who took part in a digital psychotherapy program. The goal was to create fair and accurate …

This study created and tested a mobile app called VetEd for student veterans dealing with mental health issues like depression, PTSD, or anxiety. The goal was to help them manage academics, mental health, and find resources. Researchers worked with 13 veterans to see if the app w…

This completed Phase 2 trial tested whether a drug called CVL-562 can change brain activity related to working memory in people with early schizophrenia. 112 participants received different doses or a placebo while undergoing brain scans. The goal was to find brain imaging marker…

This completed study looked at 224 adults who already had at least one psychiatric condition to see how many also had undiagnosed ADHD. Researchers measured how often ADHD was missed and tracked quality of life in those diagnosed. The goal is to highlight the need for better dete…

This study looked at how people aged 18-30 with early psychosis process information about their surroundings, compared to those without a psychiatric diagnosis. Participants completed computer-based tasks and cognitive training. The goal was to better understand thinking patterns…

This completed study looked at how people aged 15-45 with early psychosis process information from their surroundings, compared to healthy young adults. Participants completed computer tasks and had their brain activity measured using EEG and MRI scans. The goal was to better und…

This pilot study tested whether a nurse-led community-based rehabilitation program is feasible and acceptable for people with psychosis in Blantyre, Malawi. Sixty adults with psychosis were randomly assigned to either usual care or the home-based program. The study focused on rec…

This study tested a system where police officers can call a mental health provider during encounters with people who have serious mental illness. The goal was to see if this reduces arrests and helps people stay connected to care. Over 1,400 participants were randomly assigned to…

This study looked at whether using very low nicotine cigarettes along with nicotine-containing e-cigarettes can reduce harmful chemical exposure in smokers with mental health conditions. 88 participants were assigned to different combinations of cigarettes and e-cigarettes. The m…