Renal pelvis/ureter urothelial carcinoma

This early-stage trial tests a personalized cancer vaccine for people with bladder or stomach cancer who still have tiny amounts of cancer DNA in their blood after surgery. The vaccine is made from unique proteins in each person's tumor and aims to train the immune system to find…

This study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy before surgery helps shrink tumors in people with high-grade upper urinary tract cancer. About 131 adults will be randomly assigned to receive either chemo alone or chemo plus durvalumab be…

This early-phase trial is testing a gene therapy called nadofaragene firadenovec for people with low-grade upper tract urothelial cancer. The drug is instilled directly into the kidney's renal pelvis. The study aims to see if it is safe and can eliminate the cancer. Twenty adults…

This study tests a new drug called dabogratinib in 230 adults with a rare, low-grade cancer in the upper part of the urinary tract. The goal is to see if the drug can make the cancer disappear completely within 6 months. Participants take the drug by mouth and are monitored for s…

This named patient program gives doctors controlled, pre-approval access to a mitomycin gel called JELMYTO for specific patients with cancer of the renal pelvis or ureter. It is for people in select countries where the treatment is not yet approved and who have exhausted other op…

This study tests a new gel-like drug, UGN-104, placed directly into the upper urinary tract to treat low-grade cancer. About 70 adults with small tumors will receive the treatment to see if it can completely eliminate visible cancer. The goal is to control the disease and avoid m…

This trial is investigating whether giving a combination of gemcitabine and trastuzumab rezetecan before surgery can improve outcomes for people with HER2-positive upper tract urothelial carcinoma, a rare cancer of the kidney's drainage system. Participants will receive four cycl…

This study tests a gel form of the chemotherapy drug gemcitabine, called ST-02, for people with low-grade cancer in the upper urinary tract. The gel is placed directly into the kidney through a small tube. The goal is to see if it can destroy tumors within three months and remain…

This trial tests whether giving two drugs—enfortumab vedotin and pembrolizumab—before surgery can improve outcomes for people with upper tract urothelial cancer (a type of bladder cancer in the kidney or ureter). Participants receive the drugs intravenously, then undergo surgery …

This phase 2 trial is testing whether giving two drugs—pembrolizumab and enfortumab vedotin—before and after surgery can improve outcomes for people with high-risk upper tract urothelial cancer. The drugs are designed to help the immune system attack cancer cells and deliver a ta…

This phase 2 trial is testing two drugs—tislelizumab and disitamab-vedotin—given before surgery for a rare cancer of the upper urinary tract (UTUC) that is HER2-positive and high-risk. The goal is to see if the combination can shrink or eliminate tumors, making surgery more effec…

This trial is testing whether adding a template lymph node dissection (removing nearby lymph nodes) to the standard surgery for high-risk upper tract urothelial cancer helps patients live longer without the cancer returning. About 150 participants will be randomly assigned to get…

This study tests whether a procedure that filters a patient's blood (therapeutic plasma exchange) can help standard cancer drugs work better in people with advanced bladder or urinary tract cancer that has stopped responding to previous treatments. About 70 adults will be randoml…

This study tests a two-drug combination (gemcitabine and Jelmyto) given in sequence to treat a high-risk type of upper urinary tract cancer. The goal is to destroy the tumor without removing the kidney, which is the usual treatment. About 28 adults with non-invasive, high-grade c…

This early-stage study tests a new treatment for people with advanced bladder cancer that has not responded to standard therapies. The treatment uses specially engineered immune cells (CAR-NK cells) from a healthy donor, designed to target two proteins on cancer cells. Participan…

This study tests whether giving a targeted drug (enfortumab vedotin) plus an immunotherapy (pembrolizumab) before surgery to remove part or all of the bladder can improve outcomes for people with advanced bladder or urinary tract cancer. About 75 adults with cancer that has sprea…

This phase II trial tests two drugs—enfortumab vedotin and pembrolizumab—in 20 people with high-grade upper tract urothelial cancer who cannot or choose not to have surgery to remove the kidney and ureter. The goal is to see if the combination can control the cancer and preserve …

This study looks at whether a combination of radiation and immunotherapy works better than standard chemotherapy after surgery for a rare type of kidney cancer called upper tract urothelial carcinoma. About 178 patients with high-risk features will be followed to see which treatm…

This phase 2 trial is testing whether a targeted drug called disitamab vedotin, given together with radiation therapy, can prevent cancer recurrence in people with HER2-positive upper tract urothelial cancer who are at high risk after surgery. About 60 participants will either re…

This phase 2 trial tests two drugs—RC48 and Tislelizumab—given before kidney-sparing surgery in 20 people with high-risk upper tract urothelial carcinoma. The goal is to control the cancer while preserving the kidney, avoiding complete removal. Researchers will track how long pat…

This phase 2 trial tests whether the drug atezolizumab can shrink tumors in people with urothelial cancer before they have surgery. Participants receive two doses of atezolizumab, then undergo standard surgery to remove the tumor. Researchers will compare tissue and blood samples…

This phase 2 trial tests whether the immunotherapy drug avelumab can help prevent upper tract urothelial carcinoma from coming back after patients have already received cisplatin-based chemotherapy. About 48 adults with high-risk muscle-invasive or node-positive disease who show …

This study is for people with metastatic urothelial cancer (a type of bladder cancer that has spread). It tests two or three drugs together: sacituzumab govitecan, enfortumab vedotin, and pembrolizumab. The goal is to find the safest doses and see how well the combination shrinks…

This study tests whether a medication called 5-ALA, already used in brain surgery, can make upper urinary tract tumors glow under blue light during surgery. About 10 adults with known or suspected tumors will take 5-ALA before their procedure. The goal is to see if this technique…

Researchers are testing a urine-based fluorescence assay to see if it can detect urological cancers in people who have blood in their urine. The study enrolls 170 adults scheduled for cystoscopy or ureteroscopy. Urine samples are collected before endoscopy and analyzed with the a…

This study tests if a very thin, single-use camera can be used in a doctor's office to look for cancer in the upper urinary tract, instead of doing it in an operating room under general anesthesia. Ten adults with known or suspected upper tract urothelial carcinoma will undergo t…

This study is testing whether a urine test can accurately detect urothelial carcinoma, a type of cancer that includes bladder cancer. Researchers are comparing the test results to standard tissue biopsies in 800 adults with blood in their urine and suspicious imaging findings. If…

This study is testing a new urine test called UroAmp to see if it can accurately detect bladder cancer and monitor for its return. Researchers will collect urine and tumor samples from 2,500 people being evaluated or treated for bladder cancer or related conditions. The goal is t…

This study is testing a new urine test called Bladder EpiCheck to see how well it can detect bladder cancer in people aged 45 and older who have blood in their urine. Researchers will compare the test results to standard cystoscopy (a camera exam of the bladder). The goal is to f…

This trial tests whether rinsing the bladder with sterile water during surgery works as well as a chemotherapy drug (gemcitabine) placed directly into the bladder to prevent cancer from coming back. People with upper tract urothelial carcinoma who are having surgery to remove the…

This study looks at whether doing simple exercises at home before bladder or upper tract cancer surgery can help patients feel stronger and recover faster. About 128 adults scheduled for surgery will either receive a personalized home exercise plan via a smartphone app or standar…

This study is testing whether a blood test can find tiny pieces of tumor DNA in people with muscle-invasive bladder cancer or upper tract urothelial cancer. Researchers will compare DNA from tumor tissue with DNA in blood samples taken during routine care. The goal is to see how …

This study collects tissue and blood samples from 1,500 people with prostate or bladder cancer that has come back or spread. Researchers will analyze the samples to find genetic changes and other markers that may explain why some cancers stop responding to treatment. The goal is …

This study follows 300 men with upper tract urothelial cancer (UTUC), a rare cancer of the kidney's drainage system, to track their long-term survival, recurrence, and complication rates. By prospectively collecting data from patients before and after surgery or other interventio…

This study follows 300 Korean adults with high-grade upper tract urothelial carcinoma (a type of cancer in the kidney or ureter) to monitor for cancer recurrence. Participants will receive standard treatment (chemotherapy before surgery to remove the kidney and ureter) and provid…

This study follows 2500 people with a rare cancer of the kidney's upper urinary tract (UTUC) to see if kidney-sparing surgery works as well as removing the whole kidney. Researchers will track survival, cancer return, kidney function, and quality of life over 10 years. Anyone dia…

This study looks at whether tumor DNA found in blood and urine can help predict if cancer will come back after surgery in people with a rare type of bladder and kidney cancer. Researchers will follow 84 patients who have had surgery and are receiving chemotherapy or immunotherapy…

This pilot study is testing whether a flexible camera (ureteroscope) can be used under local anesthesia to check for cancer recurrence in the upper urinary tract after kidney-sparing surgery. Ten adults who have had such surgery will undergo the procedure in an outpatient setting…

This study looks at whether removing lymph nodes during standard kidney-ureter surgery helps people with upper tract urothelial carcinoma. About 94 adults with this rare cancer will be randomly assigned to get either the standard surgery alone or the surgery plus lymph node remov…