Pituitary deficiency

This study tests an oral medication called LUM-201 in children with growth hormone deficiency who have not yet received treatment. The goal is to see if taking a pill daily can improve growth as effectively as standard daily injections. The trial also looks for a way to identify …

This study tested a new growth hormone medicine, somapacitan, given once a week, against the standard daily Norditropin in 200 children with growth hormone deficiency. After one year, children receiving the weekly shot grew just as much in height as those on daily shots, with sim…

This study tested an oral drug called LUM-201 in 15 children with growth hormone deficiency who had already received daily injections for a year. The goal was to see if LUM-201 could maintain or improve growth over 12 months. The drug was given once daily by mouth, and researcher…

This study tested a new once-weekly growth hormone injection (somapacitan) against the standard daily growth hormone shot in 76 children with growth hormone deficiency who had never been treated before. The main goal was to see how well the weekly shot worked for height growth an…

This completed Phase 3 study tested somatropin, a synthetic growth hormone, in 33 Japanese children and adults with Prader-Willi syndrome. The goal was to see if it safely improves body composition by increasing lean body mass and reducing fat. Participants were divided into thre…

This study tested a new medicine, somapacitan, given once a week against the standard daily growth hormone shot (Norditropin®) in 110 Chinese children with growth hormone deficiency. The goal was to see if the weekly shot works as well as the daily one for helping children grow. …

This study looked at whether growth hormone therapy can improve muscle strength, power, and body composition in short prepubertal boys, both those with growth hormone deficiency and those with idiopathic short stature. Thirty short boys received growth hormone injections for 12 m…

This completed trial tested a personalized program of physical activity, nutrition guidance, and education for 128 adults with Prader-Willi syndrome. Participants followed the program during a 5-week hospital stay, with the goal of stabilizing or reducing their body mass index (B…

This study tested whether infusing mannitol, a sugar alcohol, can help diagnose polyuria-polydipsia syndrome—a condition of excessive thirst and urination. Researchers measured copeptin levels in 42 healthy adults and patients after mannitol or placebo infusion. The goal was to s…

This phase 2 study tested whether pitolisant, a drug that promotes wakefulness, can safely reduce excessive daytime sleepiness in people with Prader-Willi syndrome. The trial enrolled 65 participants aged 6 to 65 and compared pitolisant to a placebo over 11 weeks, followed by an …

This study tested whether oxytocin nasal spray, sometimes called the 'love hormone,' can improve behavior and eating problems in adults with Prader-Willi syndrome. Fifty participants received either oxytocin or a placebo daily or every three days for 28 days. Researchers measured…

This study looked at people with low or no GnRH, a hormone that controls puberty and fertility. Researchers studied 111 adults and teens to understand how GnRH problems affect the body. The goal was to find new hormone patterns and genetic causes, not to test a treatment.

This pilot study tested whether a single dose of oral estrogen-progestin can raise oxytocin levels in people with arginine vasopressin deficiency (AVD), a rare condition that also causes low oxytocin. Researchers compared 28 adults—some with AVD and some healthy—to see if oxytoci…

This completed observational study at Uşak University examined 150 adults hospitalized in the endocrinology department. Researchers measured breathing, muscle strength, pain, fatigue, sleep quality, physical activity, balance, and nerve function. The goal was to better understand…

This completed study looked at how appetite-regulating hormones change in infants with Prader-Willi syndrome during the first four years of life. Researchers collected blood samples from 215 infants to understand why they switch from poor feeding to severe overeating and obesity.…

This study tested whether people with hypopituitarism (a condition where the pituitary gland doesn't work properly) have lower oxytocin levels compared to healthy individuals. Researchers gave participants a drug called exenatide (a GLP1 receptor agonist) to see if it could stimu…

This study looked at 500 children who had surgery for a rare brain tumor called craniopharyngioma. Researchers used MRI scans to grade how much the tumor damaged a key brain area (the hypothalamus). They found that more damage was linked to higher rates of growth hormone deficien…

This study reviewed medical records of 12 children with CHARGE syndrome who had cochlear implant surgery. Researchers looked at their ear bone structure and surgical challenges to find ways to make the operation safer. The goal is to help surgeons better prepare for the unique an…

This completed study looked at whether a blood test for a substance called ADMA can measure blood vessel health in children with growth hormone deficiency or those born small for their age. Researchers compared ADMA levels to ultrasound measurements of artery function in 23 child…

This completed study involved 40 families of children with growth hormone deficiency. Researchers used data from connected injector devices and family surveys to develop a personalized growth hormone treatment profile (PGTP) report. The goal is to help doctors create more tailore…

This study measured the biological (epigenetic) age of 10 children with growth hormone deficiency before and after 6 months of hormone therapy. Researchers wanted to see if treatment changes how old their cells appear. The goal is to better understand growth hormone's effects on …