Sugar alcohol infusion may help diagnose thirst disorders
NCT ID NCT06542198
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether infusing mannitol, a sugar alcohol, can help diagnose polyuria-polydipsia syndrome—a condition of excessive thirst and urination. Researchers measured copeptin levels in 42 healthy adults and patients after mannitol or placebo infusion. The goal was to see if copeptin responses differ between healthy people and those with specific thirst disorders, potentially improving diagnosis.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
mannitol infusion
What this could lead to
If successful, this could lead to a more accurate diagnostic test for distinguishing between different causes of excessive thirst and urination.
What could go wrong
This is a small, early proof-of-concept study with only 42 participants, so results may not apply broadly. The test is experimental and not yet ready for routine use.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University Hospital Basel
Basel, 4031, Switzerland