Growth hormone may turn back the clock in kids – but Don't get excited yet

NCT ID NCT06294860

Completed Knowledge-focused Sponsor: Istituto Auxologico Italiano Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study measured the biological (epigenetic) age of 10 children with growth hormone deficiency before and after 6 months of hormone therapy. Researchers wanted to see if treatment changes how old their cells appear. The goal is to better understand growth hormone's effects on aging and improve follow-up care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: recombinant growth hormone (rhGH)
What this could lead to: If successful, this could help doctors better monitor growth hormone therapy and understand how it affects biological aging in children.
What could go wrong: This is a very small, completed study with only 10 children. It measured biological age markers, not health outcomes, so results may not change treatment or apply broadly.

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Conditions

The condition(s) this trial relates to.

Dwarfism isolated congenital growth hormone deficiency pituitary dwarfism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GROWTH HORMONE DEFICIENCY SHORT STATURE

Contacts and locations

Locations

Istituto Auxologico Italiano

Milan, 20145, Italy

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