Parasitic infectious disease

This early-stage trial tests a new malaria vaccine called PfSPZ-LARC2 in up to 22 healthy adults who have never had malaria. The vaccine uses live but genetically weakened malaria parasites that stop developing late in the liver, aiming to trigger a stronger immune response than …

This early-stage study tests whether giving the R21/Matrix-M malaria vaccine in a new, escalating-dose schedule is safe and creates a strong immune response. It involves 36 healthy adults in the UK who have never had malaria. The goal is to find a better way to protect people fro…

This study tests two experimental malaria vaccines in 360 children aged 5 to 36 months in Burkina Faso, a country where malaria is common. The vaccines aim to prevent malaria caused by the Plasmodium falciparum parasite. Researchers will check how safe the vaccines are, how well …

This study tests two experimental vaccines designed to stop the malaria parasite from spreading from person to person. The vaccines target the parasite's development inside mosquitoes, so vaccinated people who get bitten are less likely to pass the infection on. The trial involve…

This study tests the R21/Matrix-M1 malaria vaccine in 330 healthy women aged 18–35 in Mali who may become pregnant. Participants receive two or three doses of the vaccine or a placebo, and are followed for two years to check safety, immune response, and protection against malaria…

This large-scale study tests the R21/Matrix-M vaccine to prevent malaria in 4,800 children aged 5-36 months living in Africa. The vaccine aims to protect against the most dangerous form of malaria. Researchers will measure how well it works and check for side effects over one yea…

This study tests a new malaria vaccine called SUM-101 in 69 healthy children and infants aged 5 months to 5 years in Burkina Faso. The goal is to see if the vaccine is safe and triggers a strong immune response. Participants receive three doses, and some infants also receive a ra…

This phase 3 trial tests whether a single dose of emodepside can cure soil-transmitted worm infections (like whipworm, hookworm, and roundworm) better than the standard 3-day course of mebendazole. About 315 adolescents and adults with confirmed infections will receive either emo…

This study tests whether the drug benznidazole can cure chronic Chagas disease in children aged 2 to 18. All 178 participants receive the drug, and their results are compared to a historical placebo group. The main goal is to see if the infection clears based on blood tests over …

This trial compares two new types of insecticide-treated bed nets against standard nets to see if they better prevent malaria in children aged 6 months to 10 years in central Côte d'Ivoire. About 1,650 people are taking part across multiple villages. The new nets contain either a…

This study looks at whether a special team of doctors and nurses can treat adults with suspected infections at home, instead of sending them to the hospital. About 500 people will be randomly assigned to either standard hospital care or home-based care from a mobile response team…

This study tests whether adding a daily nutrient supplement (SQ-LNS) to monthly malaria prevention visits can reduce both malaria and malnutrition in children aged 6-24 months in Burkina Faso. Researchers will compare malaria rates and nutritional status between children receivin…

This study looks at whether giving a rectal gel (rectal artesunate) followed by three days of malaria pills works as well as the standard injected treatment for young children with severe malaria. It involves about 2,000 children aged 6 months to 5 years in remote areas of Zambia…

This study tests whether giving menstrual cups to economically vulnerable women in Kenya can lower rates of bacterial vaginosis (BV) and sexually transmitted infections (STIs). The cup is a reusable silicone device that collects menstrual blood and can be worn during sex. Researc…

This study tests if taking moxidectin twice a year is safer and more effective than once a year for treating river blindness, a parasitic disease. About 323 people in the Democratic Republic of Congo will receive either moxidectin or ivermectin annually or biannually. The goal is…

This study tests four different drug combinations in 300 adults with onchocerciasis (river blindness), a parasitic disease. Participants first receive ivermectin to clear skin and eye parasites, then get one of the new combos. The goal is to see which combo is safest and most eff…

This study looked at how two different malaria drug combinations work in children with uncomplicated malaria in Zambia. The goal was to see how well the drugs clear malaria parasites from the blood and prevent new infections for up to 9 weeks. About 182 children took part, and re…

This study tests two types of light therapy—low-level light and intense pulse light—to kill Demodex mites that cause eyelid inflammation (blepharitis). 88 adults with confirmed mite infections will receive one of four treatments: sham, blue light alone, IPL alone, or both. All wi…

This study evaluates a new blood test called Xpert Tropical Fever that can quickly detect several tropical diseases like malaria, dengue, and Zika from a small blood sample. Researchers will enroll 2,500 people with fever symptoms to see how accurate the test is compared to stand…

This Phase 1 trial in Mali will test the safety of the PfSPZ malaria vaccine in 400 healthy pregnant women aged 18-34. Participants will receive three injections of either the vaccine or a placebo. The study will monitor both mothers and their infants for up to a year after birth…

This Phase 3 trial in Uganda tests whether giving young children monthly malaria prevention medicine (dihydroartemisinin-piperaquine) from 8 weeks to 1 or 2 years of age helps them develop stronger immunity against malaria later. 924 children are enrolled and followed until age 4…

This study tests whether screening pregnant women for malaria with a highly sensitive rapid test during the first trimester, followed by treatment if positive, can improve newborn health. Over 2,000 women in malaria-prone areas will be compared to those receiving usual care. The …

This study aimed to see if sending health workers to find malaria cases in high-risk villages and among forest workers could lower malaria rates better than usual care. It planned to track infections over 18 months in southern Laos. However, the study was withdrawn before any par…

This study tests whether replacing dirt floors with concrete in rural Bangladeshi homes can reduce infections in children. About 800 pregnant women and their future babies will take part, with children checked for parasites and diarrhea up to age 2. If concrete floors lower infec…

This large study in Sierra Leone is testing whether giving children an antibiotic (azithromycin) along with malaria prevention medicine during their regular vaccine visits can lower the number of deaths in children under 5. Over 20,000 children are taking part. The goal is to fin…

This study tests whether giving antimalarial drugs to entire communities can reduce malaria transmission. About 18,000 people in 50 villages in Senegal will take part. The goal is to clear hidden malaria parasites that standard treatments miss, especially during the dry season.

This study tests whether giving school children preventive malaria medicine can reduce infections not only in them but also in younger siblings at home. About 1,000 students in rural Malawi will receive either one of two drug combinations or no preventive treatment. Researchers w…

This study tests the safety of an experimental medicine called L9LS in infants aged 1 to 12 months in Mali. It also looks at how L9LS affects the immune response to a malaria vaccine called R21/Matrix-M. The goal is to find a better way to prevent malaria in young children.

This study looks at whether taking 450 mg of ashwagandha root extract daily for six weeks can reduce stress, improve recovery, and boost muscle strength in young male football players. Sixty-two participants will be randomly assigned to receive either the supplement or a placebo.…

This study looks at HIV-negative people who get opportunistic infections—illnesses that usually only affect those with weak immune systems. Researchers want to find out if these patients have unusual antibodies that block a key immune signal. Up to 224 adults in Thailand and Taiw…

This study tracks how the malaria drug artemether-lumefantrine passes from a breastfeeding mother into her breastmilk and then into her nursing infant. Researchers will take blood and milk samples from 30 mother-infant pairs in Uganda over two weeks. The goal is to understand dru…

This study looks at how the bacteria in a pregnant woman's gut (her microbiome) and her nutrition affect her baby's growth and health. Researchers are following 800 young pregnant women (28 and under) in Toronto throughout pregnancy and for a year after birth. They collect stool,…

This study was designed to see if giving a single dose of an antibody called L9LS changes how well the R21/Matrix-M malaria vaccine works. It planned to enroll healthy adults and infants in Mali. However, the trial was withdrawn before any participants were enrolled, so no data w…

This study looks at how well a single dose of ivermectin works in children under 5 with scabies. Researchers want to make sure the dose is safe and effective for this age group. About 120 children in Laos will take part, and the study will measure drug levels in the blood.

This trial compares a new ivermectin powder mixed with infant formula to the standard tablet in 52 healthy adults. The goal is to see if the new formulation is absorbed similarly, tastes better, and causes no new side effects. Results will guide future use in children with scabie…

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This study tracks how often people of all ages in two Liberian villages get malaria, and how many mosquitoes carry the parasite. Researchers will test blood samples monthly and collect mosquitoes from homes. The goal is to gather data that could help decide the best way to use a …

This study looks at how having intestinal worms (helminths) and COVID-19 antibodies changes the immune system and gut bacteria. Researchers will collect blood and stool samples from 1500 people in India to measure infections and immune markers. The goal is to understand these int…

This study looks at immune cells from people with autoimmune diseases (like lupus), people with infections, and healthy volunteers. Researchers want to understand how these cells differ and what makes them attack the body in autoimmune conditions. The study involves blood and bon…