One pill to beat worms? new drug emodepside takes on mebendazole
NCT ID NCT06736691
First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether a single dose of emodepside can cure soil-transmitted worm infections (like whipworm, hookworm, and roundworm) better than the standard 3-day course of mebendazole. About 315 adolescents and adults with confirmed infections will receive either emodepside or mebendazole, and researchers will check stool samples to see if the worms are gone. The goal is to find a simpler, more effective treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- emodepside
- What this could lead to
- If it works, this could offer a simpler, single-dose treatment for common worm infections, potentially improving cure rates and reducing the need for multiple doses.
- What could go wrong
- This is a single-center trial with 315 participants, so results may not apply broadly. Emodepside is new for this use, and side effects or lower-than-expected efficacy are possible.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Public Health Laboratory - Ivo de Carneri (PHL-IdC)
Chake Chake, Tanzania
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