Orofacial cleft
MONDO:0000358A disorder of facial skeleton that is characterized by cleft lip and/or cleft palate that result in feeding, speech and hearing problems caused by failures during development.
92 clinical trials for this condition and its sub-types.
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Broader categories
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New surgical trick may improve nose shape after cleft lip repair
Disease control CompletedThis study tested a surgical technique called a dermal roll flap to support the nostril base in 45 people who had a previous cleft lip repair. The flap uses extra skin from the lip to lift and stabilize the nostril on the cleft side. Researchers measured changes in nostril positi…
Phase: NA • Sponsor: King Edward Medical University • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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New device shrinks jaw gaps in cleft patients, boosts graft success
Disease control CompletedThis study tested a new, simple device to reduce the size of wide gaps in the jawbone (alveolar clefts) in 15 people aged 12-25 with repaired cleft lip and/or palate. The device slowly pulls the bone together before a bone graft, aiming to make the graft more successful. The stud…
Phase: NA • Sponsor: Ain Shams University • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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New putty could replace painful bone grafts for kids with cleft palate
Disease control CompletedThis study tested a new calcium phosphate putty to repair bone gaps in the gums of 84 children with unilateral cleft lip and palate. The putty was compared to the standard approach of using the child's own bone. Researchers measured how much bone remained after one year, as well …
Phase: NA • Sponsor: UMC Utrecht • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC
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New jaw surgery shows promise for cleft lip and palate patients
Disease control CompletedThis study tested a modified jaw surgery (Le Fort I osteotomy) in 9 adults with cleft lip and palate who also had a misaligned bite and a bone gap in the upper jaw. The surgery aimed to improve facial structure and reduce the size of the bone defect. Researchers measured changes …
Phase: PHASE4 • Sponsor: Alexandria University • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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New dental program aims to boost oral health in kids with clefts
Disease control CompletedThis study tested whether adding extra dental checkups and video calls with a dentist could improve oral hygiene in children with cleft deformities. Sixty children aged 3 to 15 took part. The program included a longer dental visit and teleconsultations every two months. Researche…
Phase: NA • Sponsor: Nantes University Hospital • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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Sticky bone graft shows promise for fixing cleft defects
Disease control CompletedThis study tested a new method to repair a type of cleft palate that affects the upper gum (unilateral alveolar cleft). Ten patients received a 'sticky bone' graft combined with a special growth factor membrane. The researchers checked for inflammation, fluid leaking into the nos…
Phase: NA • Sponsor: Tanta University • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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New jaw expander could improve smiles for kids with cleft lip and palate
Disease control CompletedThis study tested a new device called the Leaf Self Expander to widen the upper jaw in 20 children with cleft lip and palate. The device was compared to the standard rapid maxillary expander. Researchers used 3D scans to measure changes in bone and tooth position. The goal was to…
Phase: NA • Sponsor: Al-Azhar University • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Second cleft lip surgery shows promise for better appearance
Disease control CompletedThis study looked at whether a second surgery could improve the look of the lip and nose in 25 people born with a cleft lip who already had one repair. The goal was to see if patients were happier with their appearance and function after the extra surgery. Results were measured u…
Phase: NA • Sponsor: Suez Canal University • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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New device aims to close wide gum clefts without bone grafts
Disease control CompletedThis study tested a special device placed inside the mouth to slowly pull bone across a wide gap in the gum (alveolar cleft) in 8 patients aged 7 to 20. The goal was to close the gap without needing a bone graft. Researchers measured changes in the cleft size, tooth movement, and…
Phase: NA • Sponsor: Faculty of Dental Medicine for Girls • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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Fat graft patch boosts palate hole repair in cleft patients
Disease control CompletedThis study tested a new surgical technique for repairing a common complication after cleft palate surgery: a hole (fistula) in the roof of the mouth. In 36 patients, half received the standard two-layer repair, while the other half also had a small piece of fat from the cheek pla…
Phase: NA • Sponsor: Tanta University • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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New bone graft method shows promise for kids with cleft palate
Disease control CompletedThis study tested two different bone graft materials to repair a common birth defect called alveolar cleft (a gap in the upper jaw). Fourteen children aged 8 to 12 received either a standard graft or one mixed with a special blood product. The goal was to see which material led t…
Phase: NA • Sponsor: Beni-Suef University • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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New scale could help predict fall risk for hospital patients in turkey
Diagnosis CompletedThis study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…
Sponsor: Sisli Hamidiye Etfal Training and Research Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 09:08 UTC
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Nerve block may cut opioid use in Kids' cleft palate surgery
Symptom relief CompletedThis study tested whether a special nerve block given during cleft palate repair can lower pain and reduce the need for opioids in children. Forty children having their first cleft palate surgery received the nerve block. Researchers measured pain scores and opioid use to see if …
Phase: NA • Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago • Aim: Symptom relief
Last updated Jun 27, 2026 14:02 UTC
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New drug calms kids after cleft palate surgery
Symptom relief CompletedThis study tested whether a single dose of dexmedetomidine, given during surgery, can prevent severe agitation in children aged 1-7 after cleft palate repair. Sixty children were randomly assigned to receive either the drug or a placebo (saline). The main goal was to measure emer…
Phase: PHASE3 • Sponsor: Assiut University • Aim: Symptom relief
Last updated Jun 27, 2026 12:30 UTC
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Physiotherapy students test muscle relief techniques on themselves
Symptom relief CompletedThis study looked at how common muscle and posture problems are in physiotherapy students and whether a special physiotherapy program could help. 44 students with back pain and muscle tightness received treatments like trigger point release, stretching, and joint mobilization. Th…
Phase: NA • Sponsor: Charles University, Czech Republic • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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Jaw implants aim to boost life quality after surgery
Symptom relief CompletedThis study looked at how well Global D implants work for orthognathic (jaw) surgery and whether they improve patients' quality of life. 198 people who had their first jaw surgery received these implants. Researchers measured quality of life before and after surgery using a specia…
Sponsor: Global D • Aim: Symptom relief
Last updated Jun 27, 2026 08:11 UTC
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Who should control your sedation during surgery? new study compares options
Symptom relief CompletedThis study looked at whether letting patients control their own sedation during arm surgery under regional anesthesia leads to higher satisfaction compared to having an anesthesiologist control it. 70 adults having upper limb orthopedic surgery were randomly assigned to either pa…
Phase: NA • Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche • Aim: Symptom relief
Last updated Jun 27, 2026 07:59 UTC
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Rare genetic disorder studied for clues to better care
Knowledge-focused CompletedThis study looked at Smith-Lemli-Opitz syndrome (SLOS), a rare genetic condition that affects cholesterol production and causes birth defects and intellectual disabilities. Researchers enrolled 130 patients and their mothers to learn more about the disease's progression, genetic …
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated Jul 04, 2026 00:00 UTC
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New turkish health survey could improve care for muscle and joint problems
Knowledge-focused CompletedThis study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…
Sponsor: Istanbul Bilgi University • Aim: Knowledge-focused
Last updated Jun 28, 2026 00:00 UTC
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New 3D face scans could help babies with cleft lip
Knowledge-focused CompletedThis study tested a new way to measure nose and lip shape in 14 infants with cleft lip and palate using 3D facial scans. Researchers compared these scans to standard photos and manual measurements to see if the digital method is accurate. The goal is to find a better, less invasi…
Phase: NA • Sponsor: Cairo University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:01 UTC
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Honey vs. antibiotic: which heals cleft palate surgery better?
Knowledge-focused CompletedThis study looked at whether a special honey (Trigona sp.) helps heal wounds after cleft palate surgery better than a standard antibiotic dressing. Twenty-four children aged 18 months to 6.5 years participated. Researchers measured a healing marker in saliva before and after surg…
Phase: NA • Sponsor: Hasanuddin University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:38 UTC
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Cleft Surgery's hidden impact on palate blood flow revealed
Knowledge-focused CompletedThis study looked at how routine cleft repair surgery changes blood flow in the roof of the mouth. Researchers used a non-invasive probe to measure oxygen levels in the tissue before and after surgery in 77 patients. The goal was to understand the surgery's effect on tissue healt…
Sponsor: University Hospital, Basel, Switzerland • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Physios take on ER duty: study tests if they can replace doctors for back pain
Knowledge-focused CompletedThis study tested whether specially trained physiotherapists can safely diagnose and treat non-urgent muscle and joint pain in the emergency room, compared to standard care from doctors. 102 patients with back, neck, or shoulder pain were randomly assigned to either a physiothera…
Phase: NA • Sponsor: Bern University of Applied Sciences • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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French kids help set new standard for diagnosing speech disorders
Knowledge-focused CompletedThis study measured normal nasalance scores in 131 French-speaking children aged 8 to 10 using a non-invasive device called a Nasometer. The goal is to create reference values that help doctors diagnose velopharyngeal dysfunction, a common issue in children with cleft palate, wit…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Brain scans reveal how speech therapy rewires Kids' brains after cleft palate repair
Knowledge-focused CompletedThis study used brain scans to understand how speech therapy helps children with cleft palate who have trouble speaking clearly. Researchers looked at brain connections and structure before and after therapy in 164 children aged 4 to 16. The goal was to see if therapy changes abn…
Phase: NA • Sponsor: Shufan Zhao • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Could a simple questionnaire unlock the secrets of Kids' eating disorders?
Knowledge-focused CompletedThis study tested a new parent questionnaire called ORALQUEST to assess feeding and eating disorders in children aged 9 months to 6 years. Researchers included 338 children with chronic conditions like heart defects or autism, as well as those with picky eating. The goal was to s…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:04 UTC
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Can CRPS patients imagine movement? new study investigates
Knowledge-focused CompletedThis completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Computer simulations could help fix breathing in cleft lip patients
Knowledge-focused CompletedThis study used computer simulations to analyze airflow in the noses of 12 adults with a cleft lip nasal deformity who were scheduled for surgery. The goal was to better understand how the deformity affects breathing and to help doctors plan more effective surgeries. The research…
Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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Mind, spirit, and pain: new study explores what chronic pain patients really believe
Knowledge-focused CompletedThis study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …
Sponsor: Gulseren Demir Karakilic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC
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Nerve blocks may cut opioid use in newborn cleft lip repair
Knowledge-focused CompletedThis completed study looked at 111 newborns who had cleft lip repair surgery. Researchers compared those who received a regional nerve block for pain relief to those who did not. The goal was to see if the nerve block reduced the amount of opioid pain medicine needed during and a…
Sponsor: Brno University Hospital • Aim: Knowledge-focused
Last updated Jun 26, 2026 15:22 UTC