Orofacial cleft
MONDO:0000358A disorder of facial skeleton that is characterized by cleft lip and/or cleft palate that result in feeding, speech and hearing problems caused by failures during development.
92 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
-
3D-Printed bone plug could improve cleft palate surgery
Disease control OngoingThis study compares two ways to rebuild bone in the gum area of children with a cleft palate. One method uses a custom 3D-printed mold to shape the patient's own bone into a plug, while the other uses small bone chips. The goal is to see which approach fills the bone gap better a…
Phase: NA • Sponsor: Cairo University • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
-
Pain-blocking shot for kids' cleft palate surgery never tested
Symptom relief TerminatedThis study planned to test whether a nerve block in the cheek area could reduce the need for morphine after cleft palate repair in children aged 5 months to 12 years. The experimental group would have received the nerve block, while the control group would not. However, the study…
Phase: NA • Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Symptom relief
Last updated Jun 27, 2026 13:07 UTC
-
New dissolvable foods could ease Post-Surgery feeding for kids
Symptom relief ENROLLING_BY_INVITATIONThis study looks at whether special high-dissolving foods can improve feeding quality of life for children aged 6 months to 18 years after craniofacial surgery. Half of the 160 participants will receive these foods after surgery, while the other half will follow standard care. Re…
Phase: NA • Sponsor: NYU Langone Health • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
-
Smart toothbrush trial for cleft surgery kids pulled before it started
Symptom relief TerminatedThis study aimed to see if using a connected toothbrush (Ara® KOLIBREE) for one month before alveolar bone graft surgery could improve oral hygiene in children aged 5 to 12 with cleft lip and palate. The trial was withdrawn before enrolling any participants, so no results are ava…
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
-
Nerve block may cut opioid use after cleft palate repair
Symptom relief OngoingThis study tests whether a nerve block placed in the face can reduce pain and the need for strong opioid drugs after cleft palate surgery in children. The goal is to help kids start eating and drinking sooner and go home faster. The study involves 40 children having cleft palate …
Phase: PHASE4 • Sponsor: University of Florida • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
-
Phone AI helps babies smile through surgery
Symptom relief OngoingThis study tests whether a smartphone-based AI tool can help doctors give a pain-blocking injection to babies having cleft lip repair. The goal is to reduce pain during surgery and the need for extra pain medicine. The study includes 120 infants aged 5-18 months and compares the …
Phase: NA • Sponsor: Ain Shams University • Aim: Symptom relief
Last updated Jun 27, 2026 07:58 UTC
-
Weekly Check-Ins could boost patient satisfaction for chronic pain
Knowledge-focused TerminatedThis study looked at whether having more frequent contact with a clinician (at least once a week) improves satisfaction for people with long-lasting musculoskeletal conditions. Participants were split into two groups: one with standard contact and one with extra check-ins via tex…
Phase: NA • Sponsor: University of Texas at Austin • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
-
Can a special clinic get workers back on the job faster? norway launches massive study.
Knowledge-focused OngoingThis study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…
Phase: NA • Sponsor: Nordlandssykehuset HF • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
-
Which expander works best for cleft kids? new trial aims to find out
Knowledge-focused OngoingThis study compares two dental devices—the quadhelix and mini-hyrax expanders—in 24 children with cleft lip and palate who need their upper jaw widened before bone graft surgery. Researchers will use 3D scans and models to measure how much the jaw expands. The goal is to see whic…
Phase: NA • Sponsor: Cairo University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
-
Massive PT study mines 4 million records to find what works best
Knowledge-focused OngoingThis study looks back at the medical records of about 4 million people who had physical or occupational therapy for muscle and joint problems. Researchers want to see if different ways of giving therapy lead to different results. No new treatments are tested—the goal is to learn …
Sponsor: ATI Holdings, LLC • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:11 UTC
-
Phone app vs. doctor: can a mobile tool catch infections after surgery?
Knowledge-focused TerminatedThis study aimed to see if a mobile monitoring tool could accurately identify surgical site infections (SSIs) in orthopedic surgery patients, compared to the usual manual review. The study was withdrawn before enrolling any participants, so no results are available. It was design…
Phase: NA • Sponsor: Stanford University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
-
Cleft care network aims to boost outcomes by sharing data
Knowledge-focused ENROLLING_BY_INVITATIONThis study brings together medical teams that treat children with cleft lip and/or palate. They will collect information on speech, hearing, dental health, and quality of life from about 1,000 patients. The goal is to compare results across centers and find ways to improve care. …
Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC