Opioid abuse

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This study tests whether a new four-session group program, called the First Step Program, can be delivered in hospital settings and help people with substance use disorders. The program combines motivational interviewing, acceptance and commitment therapy, and group support to bo…

This study tests a short case management program for people who have been involuntarily admitted to a psychiatric hospital. The program, designed with input from people who have experienced coercion, provides up to five sessions with a nurse or social worker starting during the h…

This study tests whether patient navigation—a series of coaching sessions—helps pregnant women with opioid use disorder stay in treatment and reduce drug use. About 429 pregnant women will be randomly assigned to either usual care or patient navigation, which includes up to 14 se…

This study tests whether a virtual session with a peer recovery coach can help incarcerated adults with substance use disorders connect to addiction treatment and recovery resources. About 550 participants in jail will either get the coaching or just standard information. Researc…

This study looks at whether a program called EMPOWER, led by trained peer supporters, can help homeless veterans with substance use or mental health issues stay engaged in care and avoid repeated hospital stays or emergency visits. About 278 veterans in permanent supportive housi…

This study will test an app called JomCare that sends personalized support to men who have sex with men when they are most likely to engage in chemsex (using drugs before or during sex). The goal is to reduce risky behaviors and prevent new HIV infections. About 482 HIV-negative …

This study will bring medication for addiction and cognitive behavioral therapy to homeless veterans living in VA supportive housing. The goal is to help them stay housed and reduce substance use. About 8,000 veterans across multiple VA sites will take part.

This study tests if adding a safe dye to a drink can prove that urine samples are real and not tampered with. About 114 adults with substance use disorder will drink Gatorade with or without the dye, then provide a urine sample 15 minutes later. Researchers will check for the dye…

This study tests whether a social network approach can encourage people who inject drugs to start HIV prevention medication (PrEP) and addiction treatment (MOUD). About 398 participants will be assigned to either the LINKED intervention or a control group. The goal is to see if p…

This trial compares two types of nerve blocks given before breast surgery to see which better prevents chronic pain that can last for months. Women aged 18-65 scheduled for mastectomy will receive either a serratus posterior superior intercostal plane block or an erector spinae p…

This study tests whether a type of cognitive training called Action-Based Cognitive Remediation (ABCR) can improve thinking skills in people with various psychiatric conditions like depression, schizophrenia, anxiety, PTSD, and autism. Participants will complete computer exercise…

This study tests whether listening to short, guided mindfulness audio recordings before and after surgery for a broken arm or leg can help reduce pain, anxiety, and the need for opioid painkillers. Fifty adults will be randomly assigned to either the mindfulness group or a contro…

This study tests whether equine-assisted therapy (working with horses) can improve mental health and reduce cravings in people recovering from addiction. Twenty-two adults who have completed detox will be randomly assigned to either receive 22 sessions of equine therapy over 24 w…

This study tests whether an extra nerve block given during weight-loss surgery can lower pain, nausea, and the need for painkillers in the first three days after surgery. About 200 adults having gastric bypass or sleeve gastrectomy will be randomly assigned to get either standard…

This study tests a nerve block given during minimally invasive colorectal surgery to see if it reduces pain and the need for opioids. Researchers will track 400 adults having left-sided colon or rectal surgery. The goal is to improve recovery and reduce side effects like nausea.

This study aims to adapt and validate a French version of the Recovery Assessment Scale (RAS), a questionnaire that measures how people feel about their own recovery from mental health conditions. Researchers will ask 260 adult psychiatric patients in France to fill out the RAS a…

This study tests a training program called Project ECHO to help rural jails start or increase use of medications (methadone, buprenorphine, naltrexone) for opioid use disorder. Staff from 40 jails will attend online sessions with experts and peers over 18 months. Researchers will…

This study looks at whether adding a clinical pharmacist to community mental health teams (called FACT teams) helps people with severe mental illness and substance use disorders feel better and manage their medications more effectively. About 160 adults will take part, and the st…

This pilot study tests whether a specially designed family therapy program is practical and well-liked by women who have opioid use disorder and are involved in the justice system. About 120 women and a family member will take part, with some receiving the therapy plus usual care…

This study will observe 60 adults in residential therapeutic communities in Mexico to understand how recovery from substance use unfolds over time. Participants will answer quick mobile surveys several times a day about cravings, mood, and social interactions for 8 to 12 weeks. T…

This study tests whether a special team of doctors, nurses, and peer supporters can help people with substance use disorders get the follow-up care they need after a hospital stay. The team meets patients in the hospital and provides support and treatment after they leave, helpin…

This study tests whether adding a career counseling program called Purposeful Pathways to standard job training helps veterans with mental health and substance use disorders find and keep quality jobs. About 254 veterans from three VA sites will take part. The goal is to improve …

This study tests if a 12-week one-on-one support program is easy to complete and acceptable for people supporting a loved one who recently finished substance use treatment. About 18 participants will attend weekly telehealth sessions and complete surveys and interviews. The goal …

This study will test a tool called the Health Improvement Profile (HIP) in a mental health inpatient unit. The HIP is a checklist that helps clinicians spot physical health problems like high blood pressure or poor diet in people being treated for mental illness. Researchers will…

This study tests whether a digital screening and brief intervention can help postpartum mothers reduce substance use. About 120 mothers enrolled in home visiting programs will complete online sessions and receive text messages. Researchers want to see which combination of digital…

This study looks at how kratom affects people who have used opioids in the past. Researchers will compare kratom to another substance and a placebo to see how the body processes it and what effects it has. The goal is to better understand the potential risks and benefits of krato…

This study tests a 12-week Instagram program led by trained peers to help young adults (ages 18-25) who misuse prescription opioids. Participants will receive interactive modules and support via private Instagram groups. The goal is to see if the program is engaging, acceptable, …

This study aims to better understand psychiatric disorders, thinking problems, and treatment side effects in 2000 cancer patients and their close relatives. Researchers will compare those with and without mental health issues to find patterns and improve care. No new treatments a…

This study looks at how opioid use affects oxidative stress in adults. Researchers will collect blood samples and health information from 120 people taking opioids like morphine or fentanyl. No new treatments are given. The goal is to better understand the biological effects of o…

This study will check how much psychiatric clients know about occupational therapy (OT) and whether their expectations are realistic. It will also evaluate how well OT interns explain health information and conduct interviews. Researchers will develop new tools to measure these s…

This study tests whether a special child-resistant blister pack with clear labeling can help reduce how many opioid pills are prescribed and used after orthopedic surgery. About 352 adults will receive either the new packaging or the standard orange bottle. Researchers will track…