Myositis disease

This early-stage study is testing a new treatment called C-CAR168 for people with autoimmune diseases like multiple sclerosis, lupus, and myasthenia gravis that have not improved with standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab…

This study tests whether Maraviroc, a drug currently used for HIV, can reduce muscle inflammation and improve function in adults with myositis that hasn't responded to standard treatments. Ten participants will take a daily 300mg tablet for 12 weeks and undergo muscle biopsies an…

This early-phase trial tests a single infusion of universal CAR-T cells (RD06-05) in 30 children and adolescents with severe autoimmune diseases, including lupus, scleroderma, and kidney inflammation. The cells are designed to target and calm overactive immune cells. The main goa…

This small study will test a drug called emapalumab in 5 adults with a rare, rapidly worsening lung disease linked to dermatomyositis. The drug is already used for a similar immune overreaction condition. Researchers will check if it improves oxygen needs, lung function, and CT s…

This early-stage trial tests a one-time infusion of donor immune cells (CAR-γδT cells) designed to target and destroy faulty B cells in people with severe autoimmune diseases like lupus and scleroderma. The main goal is to check safety and find the right dose in 9 adults whose di…

This study tests a drug called teclistamab in 24 adults with a severe, rapidly worsening lung disease linked to anti-MDA5 antibodies. The disease has a very poor outlook, with only about 25% of patients surviving 90 days without a lung transplant. Teclistamab aims to improve surv…

This early-phase trial tests an injection called KSVCBD, a type of CAR-T cell therapy, in 60 adults with severe autoimmune diseases like lupus and scleroderma. The goal is to see if it's safe and to get a first look at whether it might help control the disease. Participants recei…

This early-phase trial tests a single dose of universal (off-the-shelf) CAR-T cells in 30 adults with active autoimmune diseases like lupus, scleroderma, vasculitis, myositis, or Sjögren's. The treatment targets CD19 and BCMA on immune cells to reset the faulty immune system. The…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This Phase 3 trial tests garetosmab, an antibody that blocks activin A, in 18 children and teens with fibrodysplasia ossificans progressiva (FOP), a rare disease where muscle and tissue turn into bone. The study will check safety, side effects, and whether the drug reduces new ab…

This early-stage study tests whether a single infusion of a patient's own modified immune cells (CAR-T cells) is safe for people with severe autoimmune diseases like lupus, rheumatoid arthritis, or scleroderma that haven't improved with standard treatments. Only 6 adults aged 18-…

This early-phase study tests a new treatment called BEN301, which uses specially engineered immune cells (CAR-Tregs) to calm overactive immune responses in people with autoimmune diseases like scleroderma, rheumatoid arthritis, lupus, and inflammatory muscle disease. The trial wi…

This early-stage trial tests UX016, a drug designed to help people with GNE myopathy, a rare genetic muscle-weakening disease. Researchers will give the drug or a placebo to 24 adults to see if it is safe and improves muscle strength. The study is not yet recruiting.

This early study tests a new treatment called CD19/BCMA CAR-T for people with severe autoimmune diseases like lupus and Sjögren's syndrome that haven't improved with standard care. The treatment involves taking a patient's own immune cells, modifying them to target specific immun…

This early-stage trial will test a new cell therapy called YTS109 in 12 children aged 5 to 17 with severe autoimmune diseases like lupus or scleroderma that have not responded to standard treatments. The children will receive a single infusion of these cells, and researchers will…

This study tests a drug called telitacicept in 30 adults with inflammatory myopathy, a condition where the immune system attacks muscles, causing weakness. The goal is to see if the drug is safe and can control the disease. Participants must have not responded well to standard tr…

This early-phase study tests a new drug called WGb-0301 for people with autoimmune diseases (like lupus or autoimmune hepatitis) that haven't responded to standard treatments. The drug uses mRNA technology to target and clear certain immune cells (B cells) that are causing the di…

This early-phase trial will test BCT301, a type of immune cell made from stem cells, in 10 people with severe autoimmune diseases like lupus and scleroderma. Participants receive a single infusion of these cells after a short course of chemotherapy. The main goal is to check safe…

This early study tests a new treatment called CD19 UCAR-T cells for people with autoimmune diseases like lupus, vasculitis, and Sjögren's syndrome. The therapy uses modified immune cells to target and calm the overactive immune system. The main goals are to check safety and see i…

This study tests a new treatment using CD19 CAR T-cells for people with severe autoimmune diseases that haven't improved with standard therapies. About 30 participants will receive a single dose of these engineered immune cells after chemotherapy. The goal is to see if it's safe …

This study will check if a new physical exam called Said's test can accurately diagnose biceps tendon injuries in the shoulder. Researchers will test 144 adults, including those with shoulder injuries and healthy volunteers. Two doctors will perform the new test and standard test…

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This study compares two non-invasive treatments—high-intensity laser therapy and shock wave therapy—for people with chronic shoulder pain from supraspinatus tendinitis. Researchers will measure pain and disability in 48 adults over several weeks to see which approach works better…

This study tests a new online program called TEAM-LEADS designed to help teens and young adults (ages 13-22) with lupus or dermatomyositis reduce stress and improve heart-healthy behaviors like diet, exercise, and sleep. The program is self-guided and completed online. The study …

This study tests if a newer ultrasound-guided needle works better than a standard needle to treat gluteal tendinosis—a painful tendon condition in the buttock area. About 110 adults who haven't improved after 3 months of other treatments will be randomly assigned to one of the tw…

This study tests whether adding shockwave therapy or platelet-rich plasma (PRP) injections to a standard exercise program helps people with long-term Achilles tendon pain. One hundred active adults aged 18-65 with symptoms lasting over 3 months will be randomly assigned to exerci…

This study looks at whether adding famotidine (an acid-reducing drug) to standard painkillers (paracetamol and ibuprofen) helps people with calcific tendinitis of the shoulder feel less pain and move better. About 200 adults with shoulder pain and calcium deposits will be followe…

This study tests whether taking a supplement called HMB, along with a standard rehab program, can reduce pain and improve knee function in athletes with patellar tendinopathy (jumper's knee). Thirty athletes will receive either HMB or a placebo for 8 weeks. Researchers will measu…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This study tests whether a long-hold isometric exercise can reduce pain and improve function in competitive weightlifters with patellar tendinopathy (jumper's knee). About 24 athletes will either do the supervised exercise or follow routine training. Researchers will measure pain…

This study tests whether hypnotherapy can reduce pain and anxiety in children aged 6 to 18 during needle procedures like injections or blood draws. About 70 kids with conditions like juvenile arthritis or lupus will be randomly assigned to receive either hypnotherapy or standard …

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This study tests whether applying an ozonated gel with ultrasound (phonophoresis) can reduce pain and improve shoulder function in people with chronic supraspinatus tendinitis. Forty adults aged 30-60 with mild to moderate tendon issues will receive either the ozone gel treatment…

This study looks at whether TECAR therapy, a type of energy treatment, can reduce pain and improve shoulder movement in people with chronic supraspinatus tendinitis (a common tendon injury). About 46 adults with grade II tendinitis will receive the therapy. Researchers will measu…

This study tests whether a personalized exercise program based on muscle structure works better than a standard eccentric heel-drop program for people with chronic Achilles tendinopathy. Twenty adults with mid-tendon pain for at least 3 months will be randomly assigned to one of …

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This study looks at whether two substances in the blood, IL-6 and MMP-7, can help doctors diagnose and predict the course of a rare lung disease in children. Researchers will measure these markers in 60 children with immune-mediated interstitial lung disease and compare them to h…

This study tests a new imaging technique called full-field OCT to see if it can spot muscle inflammation faster than the usual method, which takes weeks. Researchers will compare both methods on muscle samples from 20 healthy adults and people with suspected myositis. The goal is…

This study will use ultrasound to check for tendon inflammation (tenosynovitis) in children with two types of juvenile idiopathic arthritis (JIA): polyarticular and oligoarticular. Researchers will examine 106 children under 16 at Assiut University Hospital, comparing physical ex…

This study aims to understand if diet influences muscle health and daily function in adults with inclusion body myositis (IBM), a rare muscle disease. Researchers will compare 47 adults with IBM to healthy volunteers aged 40 and older. Participants will track their diet and activ…

This study looks at how athletes at risk for patellar tendinopathy (jumper's knee) move during jumps. Researchers will use a camera system to track knee, hip, and ankle angles in 60 male athletes over 12 months. The goal is to find early movement changes that could lead to better…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study will follow 1,550 adults with various neurological autoimmune diseases—like multiple sclerosis, myasthenia gravis, and autoimmune encephalitis—to see how these conditions progress and respond to treatments in everyday medical practice. Researchers will measure disabili…

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…

This study will use a special blood test called mass spectrometry to look at immune cells in 500 people with various autoimmune diseases and healthy volunteers. The goal is to find patterns that could help doctors diagnose these conditions sooner. No treatments are being tested; …

This study will collect health information, samples, and data from 100 people in Luxembourg (800 total across Europe) who have rheumatoid diseases and are starting or changing treatment. Researchers hope to find patterns that can predict which treatments work best for each person…